Trends in Incidence and Prevalence of Major Transfusion-Transmissible Viral Infections in US Blood Donors, 1991 to 1996

Glynn, Simone A.; Kleinman, Steven; Schreiber, George B.; Busch, Michael P.; Wright, David J.; Smith, James W.; Nass, Catharie C.; Williams, Alan E.

doi:10.1001/jama.284.2.229

Cited by 266 publications

(239 citation statements)

References 29 publications

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“…Despite large reductions in HIV and HCV residual risk after the implementation of NAT screening in the State of Santa Catarina, the overall HIV incidence of over one per thousand donor-years is almost one hundred times higher compared with countries such as France, Germany, the USA, Canada and Australia [20][21][22][23][24][25][26] . More effective prevention measures need to be implemented in the Brazilian general population before transfusion risk can be reduced further 1 .…”

Section: Discussionmentioning

confidence: 99%

Changes in the prevalence, incidence and residual risk for HIV and hepatitis C virus in Southern Brazilian blood donors since the implementation of NAT screening

Kupek

Petry²

2014

Rev. Soc. Bras. Med. Trop.

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Section: Discussionmentioning

confidence: 99%

Changes in the prevalence, incidence and residual risk for HIV and hepatitis C virus in Southern Brazilian blood donors since the implementation of NAT screening

Kupek

Petry²

2014

Rev. Soc. Bras. Med. Trop.

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“…A way of preventing an artificial reduction in prevalence in the donor population resulting from the increased number of repeat donors is to calculate the prevalence based only on first time donors, which is also useful for incidence and residual risk studies 6 .…”

Section: Discussionmentioning

confidence: 99%

“…The study of trends in prevalence of transmissible diseases provides a mechanism of evaluation of blood supply security and the effectiveness of blood donor deferral criteria, as well as of other measures of selection and testing 6 . The aim of this study was to analyze the evolution of prevalence of HTLV in blood donors from the Hemominas Foundation from 1993 to 2007, and to determine its geographic distribution and the demographic data for HTLV-1/2 positive blood donors in the period.…”

Section: Article/artigomentioning

confidence: 99%

Decline in prevalence and asymmetric distribution of human T cell lymphotropic virus 1 and 2 in blood donors, State of Minas Gerais, Brazil, 1993 to 2007

Dias-Bastos

Oliveira

Carneiro-Proietti

2010

Rev. Soc. Bras. Med. Trop.

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Introduction: Human T cell lymphotropic virus types 1 and 2 (HTLV-1/2) are endemic in Brazil and are screened for in transfusion services since 1993. This study evaluated the evolution of the prevalence of HTLV-1 and 2 in blood donors of the Hemominas Foundation from 1993 to 2007, and its geographical distribution in State of Minas Gerais, Brazil. Methods: The Hemominas Foundation is a centralized blood center in Minas Gerais, Brazil. The sources of data were the Hemominas Foundation Technical Bulletin and files from the centralized serological laboratory. Donors were tested in the period using enzyme linked immuno sorbent assays (ELISA), followed by Western blot, when repeatedly reactive. The data were analyzed by EPIINFO 6.2 and TABWIN 3.5 softwares. Results: The average seroprevalence in the period 1993-2007 was 0.1%. A steady decline occurred from 0.4% in 1993 to below 0.1% in 2002 and later, with a transient peak of 0.5% in 1994. HTLV reactivity distribution was asymmetrical in the state, with regions of higher prevalence, interspersed with low prevalence areas. Comparison of positive and negative donors verified that increasing age was proportional to virus positivity. Odds ratio for age ranged from 1.43 (30 to 39 years-old) to 3.09 (50 to 65 years-old). Women had a greater chance of being positive (OR-1.64), as previously described. Conclusions: Possible explanations for HTLV-1/2 prevalence decline are the exclusion of positive donors from the donor pool, an increase in repeat donors and ELISA test improvement, with reduction in the number of false positive results.

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“…Indeed, a report based on blood donors from 5 U.S. blood centers indicates that the prevalence of HCV infection may already be on a decline. 9 Between 1992 and 1996, during which time 1.1 million first-time blood donors were tested, the prevalence of HCV infection over the course of this period decreased from 0.6% to 0.4% (P Ͻ .01). Among the same blood donors, the prevalence of hepatitis B virus infection over the study period remained unchanged at 0.2%.…”

Section: Prevalence and Incidence Of Hcvmentioning

confidence: 99%

The burden of hepatitis C in the United States

2002

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Trends in Incidence and Prevalence of Major Transfusion-Transmissible Viral Infections in US Blood Donors, 1991 to 1996

Abstract: The decrease in HIV and HCV prevalence rates, combined with the previously documented lower rates of infection in first-time donors compared with the general population, suggests the continued benefit of behavioral risk factor screening. JAMA. 2000;284:229-235

Cited by 266 publications

References 29 publications

Changes in the prevalence, incidence and residual risk for HIV and hepatitis C virus in Southern Brazilian blood donors since the implementation of NAT screening

Changes in the prevalence, incidence and residual risk for HIV and hepatitis C virus in Southern Brazilian blood donors since the implementation of NAT screening

Decline in prevalence and asymmetric distribution of human T cell lymphotropic virus 1 and 2 in blood donors, State of Minas Gerais, Brazil, 1993 to 2007

The burden of hepatitis C in the United States

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