Trends in incidence and survival from anal cancer and incidence of high-grade anal intraepithelial neoplasia in Denmark

Urbutė, Aivara; Munk, Christian; Sand, Freja Lærke; Belmonte, F.; Kjær, Susanne K.

doi:10.1016/j.canep.2022.102099

Cited by 8 publications

(9 citation statements)

References 26 publications

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“…Also in line with previous findings is the lower excess mortality found among female patients compared to males. 7,9 Unlike other analyses, the impact of tumour differentiation was largely diminished in the multivariable analyses. 36 As for many other malignancies, further advances are anticipated with a role for novel immunotherapeutic agents, 37,38 Specifically those targeting the programmed cell death receptor 1 (PD-1) have shown promising results in patients with metastatic and surgically unresectable recurrent anal SCC.…”

Section: Trends In Survivalmentioning

confidence: 72%

“…In some recent reports, overall incidence of anal SCC continues to rise, whereas that of HSIL seems to decrease. [9][10][11] Decreasing incidence specifically among younger males has also been reported. 12 The observed incidence patterns of anal SCC have been linked to a rising prevalence of known risk factors aside from higher age, the most prominent being infection with high-risk human papillomavirus (hr-HPV).…”

Section: Introductionmentioning

confidence: 92%

“…The improved prognosis for patients with anal SCC over time is an assuring development, consistent with reports from other countries. 1,7,9,[34][35][36] The period of diagnosis remained independently associated with better survival even after adjustment for primary treatment modalities as well as patients' sex, age and tumour stage, which likely indicates improvements in salvage or therapeutic management of recurrent disease. Also in line with previous findings is the lower excess mortality found among female patients compared to males.…”

Section: Trends In Survivalmentioning

confidence: 99%

“…43 Indeed, the implementation of a national vaccination program in Denmark may have contributed to the decrease in incidence of HSIL that was recently observed. 9 In the Netherlands, a multivariable analyses, omitting them would introduce other sources of bias since they were not allocated at random. Lastly, due to the lack of data on cancer recurrence or progression of disease, the study could not assess progression-free survival or the benefits of salvage treatment.…”

Section: Trends In Survivalmentioning

confidence: 99%

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Trends in epidemiology and primary treatment of anal squamous cell carcinoma in the Netherlands (1990–2021)

Ho,

Deijen,

Hemmes

et al. 2023

Intl Journal of Cancer

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A rapid increase in the incidence of anal squamous cell carcinoma (SCC) was reported in several countries over the past decades. This study assessed trends in epidemiology and primary treatment over a 32‐year period (1990–2021) using the Netherlands Cancer Registry. The study population included 4273 patients, 44.2% male and 55.8% female (median age 63 years). The age‐standardised incidence rate (European Standardised Rate, ESR) increased from 0.5 to 1.6 per 100,000, which entailed an average annual percentage change (AAPC) of 5.0% (95% confidence interval [CI]: 4.5%–5.8%). While incidence among females increased continuously over the total period (AAPC 4.9%; 95%CI: 4.4%–5.6%), to 1.8 per 100,000 ESR in 2021, incidence among males increased until 2016 (annual percentage change [APC] of 6.3%; 95%CI: 5.6%–10.7%), after which it seemed to stabilise (APC −2.1%; 95%CI: −16.8%–4.5%). Significant trends were also observed in distribution of age, tumour stage and primary treatment modalities. Five‐year relative survival (RS) was estimated using the Pohar–Perme estimator, and this improved from 56.1% in 1990–1997 (95%CI: 49.3%–62.4%) to 67.9% in 2014–2021 (95%CI: 64.7%–70.9%), but remained poor for stage IV disease. Evaluation through a multivariable Poisson regression model demonstrated diagnosis in the most recent period to be independently associated with better RS, in addition to female sex, younger age, early disease stage and any treatment. In conclusion, the rising incidence of anal SCC seems to decline in males, but not in females, and advances in diagnostics and therapeutic management have likely contributed to improved prognosis.

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Section: Trends In Survivalmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 92%

Section: Trends In Survivalmentioning

confidence: 99%

Section: Trends In Survivalmentioning

confidence: 99%

See 2 more Smart Citations

Trends in epidemiology and primary treatment of anal squamous cell carcinoma in the Netherlands (1990–2021)

Ho,

Deijen,

Hemmes

et al. 2023

Intl Journal of Cancer

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“…The rate of multiple HPV infections gradually increases as age increases. It may due to different ages individuals have different lifestyles and habits [19]. Above all, the immunity of women cervical tissue decreases with age, such as the immune cells Langerhans cell function exhaustion and quantity reduced, leading single HPV infections transformed into multiple HPV infections [20].…”

Section: Discussionmentioning

confidence: 99%

Analysis of age-specified prevalence and multiple HPV-type prevalence in a Chinese population

Zhou

Zhang

Wang

et al. 2022

Preprint

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Background The human papillomavirus (HPV) is one of the most widespread viruses on the planet. A previous study found that HPV prevalence has an age-related relationship. Multiple HPV infections have a bad outcome. HPV infection is linked to uterine cervical cancer, bacterial vaginitis, cervicitis, fungal vaginitis, and pelvic inflammation, among other gynecological conditions. Furthermore, HPV infection during pregnancy has a negative impact on the health of both the mother and the fetus. In Chinese women, the prevalence of HPV and the link between HPV infection and various diseases are still unknown. Methods A Genotyping Test Kit was used to determine individual HPV genotypes (Life River Co., Shanghai, China). The prevalence of HPV types and ages was collected and analyzed by using SPSS 22.0 software. Results The HPV infection positive rate was 20.3% overall, including HPV single genotype (74.3%), HPV double genotype (18.4%), and HPV triple infections (7.4%). The top fifth prevalent HPV genotypes were HPV52 (25.5% of the positive individuals), HPV16 (19.7%), HPV58 (21.7%), HPV51 (11.4%) and HPV39 (9.6%). The < 20-year old group represented highest HPV infection rate, and HPV infection rates rise with age, especially multiple HPV infection rates. There were significant differences for fungal vaginitis (P = 0.010; χ2 = 6.61) and cervical lesions (P = 0.000; χ2 = 1069.60) with the health check group. The prevalence of HPV infection is significant popular among fungal vaginitis (P = 0.010; χ2 = 6.61) and cervical lesions (P = 0.000; χ2 = 1069.60). The early pregnant women, middle-late pregnant women HPV positive ration was lower than routine health checks HPV infection rates. hpv52: hpv58 enjoy the highest infection rate among the multiple HPV combination. Conclusion HPV infection was serious among women in China. HPV infection is linked to one's age in Chinese. Women under the age of 20 have the highest HPV prevalence, implying that HPV vaccination is required for young people. Multiple HPV infections have a cumulative effect as people become older. It's possible that HPV infection is linked to vaginitis since vaginitis makes you more susceptible to infection. HPV infections in pregnant women are common and require additional care.

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Human papillomavirus-associated cancers, precancers, and genital warts in Denmark, 2000–2022 – Current burden of disease and population impact of multi-cohort HPV vaccination

Kaderly Rasmussen,

Lindquist,

Baandrup

et al. 2024

Preventive Medicine

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Trends in incidence and survival from anal cancer and incidence of high-grade anal intraepithelial neoplasia in Denmark

Cited by 8 publications

References 26 publications

Trends in epidemiology and primary treatment of anal squamous cell carcinoma in the Netherlands (1990–2021)

Trends in epidemiology and primary treatment of anal squamous cell carcinoma in the Netherlands (1990–2021)

Analysis of age-specified prevalence and multiple HPV-type prevalence in a Chinese population

Human papillomavirus-associated cancers, precancers, and genital warts in Denmark, 2000–2022 – Current burden of disease and population impact of multi-cohort HPV vaccination

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