Trends in Incidence of Hospitalized Acute Myocardial Infarction in the Cardiovascular Research Network (CVRN)

Reynolds, Kristi; Go, Alan S.; Leong, Thomas K.; Boudreau, Denise M.; Cassidy‐Bushrow, Andrea E.; Fortmann, Stephen P.; Goldberg, Robert J.; Gurwitz, Jerry H.; Magid, David J.; Margolis, Karen L.; McNeal, Catherine J.; Newton, Katherine M.; Novotny, Rachel; Quesenberry, Charles P.; Rosamond, Wayne D.; Smith, David H.; VanWormer, Jeffrey J.; Vupputuri, Suma; Waring, Stephen C.; Williams, Marc S.; Sidney, Stephen

doi:10.1016/j.amjmed.2016.09.014

Cited by 77 publications

(54 citation statements)

References 39 publications

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“…These findings seem to be in line with reported rates of CV events in the non-CAP population, with the exception of atrial fibrillation. Yearly trends in acute myocardial infarction show that hospital admission is decreasing in both the US and in Europe [5,98]. This may reflect the improved utilization of protective CV medication in the context of better primary care based prevention including pneumococcal and influenza immunization, along with improved secondary prevention after ACS.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular Events after Community-Acquired Pneumonia: A Global Perspective with Systematic Review and Meta-Analysis of Observational Studies

Tralhão

Póvoa

2020

JCM

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Acute cardiovascular disease after community-acquired pneumonia is a well-accepted complication for which definitive treatment strategies are lacking. These complications share some common features but have distinct diagnostic and treatment approaches. We therefore undertook an updated systematic review and meta-analysis of observational studies reporting the incidence of overall complications, acute coronary syndromes, new or worsening heart failure, new or worsening arrhythmias and acute stroke, as well as short-term mortality outcomes. To set a framework for future research, we further included a holistic review of the interplay between the two conditions. From 1984 to 2019, thirty-nine studies were accrued, involving 92,188 patients, divided by setting (inpatients versus outpatients) and clinical severity (low risk versus high risk). Overall cardiac complications occurred in 13.9% (95% confidence interval (CI) 9.6–18.9), acute coronary syndromes in 4.5% (95% CI 2.9–6.5), heart failure in 9.2% (95% CI 6.7–12.2), arrhythmias in 7.2% (95% CI 5.6–9.0) and stroke in 0.71% (95% CI 0.1–3.9) of pooled inpatients. During this period, meta-regression analysis suggests that the incidence of overall and individual cardiac complications is decreasing. After adjusting for confounders, cardiovascular events taking place after community-acquired pneumonia independently increase the risk for short-term mortality (range of odds-ratio: 1.39–5.49). These findings highlight the need for effective, large trial based, preventive and therapeutic interventions in this important patient population.

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Section: Discussionmentioning

confidence: 99%

Cardiovascular Events after Community-Acquired Pneumonia: A Global Perspective with Systematic Review and Meta-Analysis of Observational Studies

Tralhão

Póvoa

2020

JCM

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“…A number of community-based studies, including previous reports from the Worcester Heart Attack Study, 4,10,13,17 as well as large coronary disease registries, 18 have shown evidence of a progressive increase in the prescribing of effective cardiac therapies in patients hospitalized with AMI during the past 2 decades. Moreover, a gradual reduction in the utilization of cardiac medications with questionable therapeutic value or a narrow therapeutic/toxic ratio was observed.…”

Section: Discussionmentioning

confidence: 99%

Changing Trends in the Landscape of Patients Hospitalized With Acute Myocardial Infarction (2001 to 2011) (from the Worcester Heart Attack Study)

Mercado–Lubo

Yarzebski

Lessard

et al. 2020

The American Journal of Cardiology

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During the past several decades, new diagnostic tools, interventional approaches, and population-wide changes in the major coronary risk factors have taken place. However, few studies have examined relatively recent trends in the demographic characteristics, clinical profile, and the short-term outcomes of patients hospitalized for acute myocardial infarction (AMI) from the more generalizable perspective of a population-based investigation. We examined decade long trends (2001 to 2011) in patient's demographic and clinical characteristics, treatment practices, and hospital outcomes among residents of the Worcester metropolitan area hospitalized with an initial AMI (n = 3,730) at all 11 greater Worcester medical centers during . The average age of the study population was 68.5 years and 56.9% were men. Patients hospitalized with a first AMI during the most recent study years were significantly younger (mean age = 69.9 years in 2001/2003; 65.2 years in 2009/2011), had lower serum troponin levels, and experienced a shorter hospital stay compared with patients hospitalized during the earliest study years. Hospitalized patients were more likely to received evidence-based medical management practices over the decade long period under study. Multivariable-adjusted regression models showed a considerable decline over time in the hospital death rate and a significant reduction in the proportion of patients who developed atrial fibrillation, heart failure, and ventricular fibrillation during their acute hospitalization. These results highlight the changing nature of patients hospitalized with an incident AMI, and reinforce the need for surveillance of AMI at the community level. © 2019 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license. (http:// creativecommons.org/licenses/by-nc-nd/4.0/) (Am J Cardiol 2020;125:673−677)Despite significant advances in patient management and population-wide lifestyle changes in several predisposing factors, acute myocardial infarction (AMI) continues to be a major cause of morbidity and mortality in the United States. 1,2 A limited number of community-based studies have described changes over time in the clinical epidemiology and outcomes of patients hospitalized with AMI in the United States. 3 These studies include the Worcester Heart Attack Study, the Minnesota Heart Survey, and Rochester Epidemiology Project. 4−12 However, few relatively recent data exist describing the potentially changing landscape of AMI at the community level. The primary objective of this population-based study was to describe decade long trends in the demographic and clinical characteristics, hospital management practices, and in-hospital clinical outcomes among residents of central Massachusetts hospitalized with a first AMI at all 11 metropolitan Worcester medical centers on a biennial basis between 2001 and 2011. MethodsDetails of the Worcester Heart Attack Study have been previously described. 4−7 In brief, residents of the Worcester metropolitan area hospital...

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“…Opposite to health disparities, gender, age and genetics are a natural disorder cause. For example, a study by Reynolds et al (2016) found that women experienced a significantly greater decrease in incidence of myocardial infarctions compared with men. Other investigators suggest that cumulative stress may result in affecting biological processes, such as shortening telomere length.…”

Section: Health Disparitiesmentioning

confidence: 99%

Conceptualization of a Predictive Model for Analysis of the Health Outcomes of Dust Events in a Society with Köppen Climate Classification BW

Molina-Herrera¹,

Ochoa²,

Gill³

et al. 2019

RCS

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High concentrations of particulate matter (PM) in the air during Dust Events (DEs) are silently impacting the health of people without their awareness. It has been demonstrated that exposure to increased levels of PM can increase the susceptibility to respiratory, circulatory, mental and other diseases due to inflammation. In addition, living in a city with Köppen climate classification type BW (arid) and subsequently with frequent high levels of PM could have a negative impact on the population's health. There are very few studies available in the southwestern United States pertaining to the associations between exposure to atmospheric aerosol after DEs and hospitalizations. Therefore, we will do a conceptualization of a predictive model to analyze the health effects of DEs in a society with Köppen climate classification type BW. We will do a representation of a system in order to understand how the DEs, hospital admissions, elevated PM levels, socioeconomic status (SES), and demographic factors work together. Preliminary results indicate that there are more admissions in all primary diagnoses during a DE than in a regular day.

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Trends in Incidence of Hospitalized Acute Myocardial Infarction in the Cardiovascular Research Network (CVRN)

Cited by 77 publications

References 39 publications

Cardiovascular Events after Community-Acquired Pneumonia: A Global Perspective with Systematic Review and Meta-Analysis of Observational Studies

Cardiovascular Events after Community-Acquired Pneumonia: A Global Perspective with Systematic Review and Meta-Analysis of Observational Studies

Changing Trends in the Landscape of Patients Hospitalized With Acute Myocardial Infarction (2001 to 2011) (from the Worcester Heart Attack Study)

Conceptualization of a Predictive Model for Analysis of the Health Outcomes of Dust Events in a Society with Köppen Climate Classification BW

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