Trends in inflammatory biomarkers during atrial fibrillation ablation across different catheter ablation strategies

Biomarkers of myocardial injury with different energy sources for atrial fibrillation catheter ablation

“…Only 1 study [6] reported increase of TnT levels in patients treated with cryoablation compared to those treated by RF ablation. Our finding that the cryoballoon resulted in a more pronounced myocardial injury is supported by 2 recent studies reporting higher cTnI levels after ablation with cryoballoon when comparing the PV ablation catheter using RF [19,26]. In our study, the higher cTnI and CK-MB levels in cryoballoon group may be explained by longer energy delivery duration compared to the other groups.…”

“…First studies focused on RF lesion and it has been demonstrated that cTnI and cTnT are more sensitive and specific than CK--MB for the diagnosis of myocardial injury after RF ablation [5,6]. It has also been showed that the rise of biomarkers and the extent of myocardial damage after RF catheter ablation depend on the number of RF pulses and site of ablation [12][13][14][15][16]19]. A lower cTn level is expected after RF of focal area with few RF lesions.…”

“…RF ablation of more myocardial tissue in the atria, such as in PV isolation, is expected to have much higher cTn levels [10][11][12][20][21][22][23][24][25]. Previous clinical studies reported contrasting data, in the setting of AF ablation, on cardiac biomarkers levels after cryoballoon ablation compared to RF ablation [7,[13][14][15][16][17][18][19]26]. Kuhne et al [7] reported higher post procedural cTnT levels in RF group vs. cryoballoon group.…”

Early Recurrence After Pulmonary Vein Isolation of Paroxysmal Atrial Fibrillation With Different Ablation Technologies – Prospective Comparison of Radiofrequency vs. Second-Generation Cryoballoon Ablation –

“…Higher troponin levels post PVI were reported when using the 1st-generation CB instead of RF catheters, 15 and with the 2nd-generation instead of the 1st-generation CB. 16 Creating complete occlusion of the PV may result in minimized convective warming of the local blood velocity and may create more extended lesions, as indicated by the higher troponin-I level.…”

Predictors of atrial fibrillation recurrence after atrial fibrillation ablation with cryoballoon

“…Eighty percent success of our study may be the result of normal LA dimen- sions, inclusion of only PAF patients, no structural heart disease, and single center study. Previous studies showed that postablation inflammation around PVs caused increase in inflammatory markers and cardiac enzymes [19,20]. When cryoballoon ablation is performed, lesion formation occurs at the entire circumference of the balloon and that results in a long circumferential lesion.…”