Trends in oropharyngeal and oral cavity cancer incidence of human papillomavirus (HPV)‐related and HPV‐unrelated sites in a multicultural population

Abstract

BACKGROUND:There is a growing recognition of the involvement of human papilloma virus infection in the etiology of head and neck cancers at some sites, mainly the base of the tongue, tonsils, and other oropharynx (hereafter termed oropharyngeal cancer). Other oral sites (hereafter termed oral cavity cancer [OCC]) show a stronger association with tobacco and alcohol. Little is known about the ethnic variation in incidence for these cancers. This study determined incidence rates of OCC and oropharyngeal cancer among South Asian, Chinese, and the general population in British Columbia, Canada. METHODS: Patients with OCC and oropharyngeal cancer diagnosed from 1980 to 2006 were identified through the British Columbia cancer registry, and surname lists were used to establish ethnicity. Age-adjusted incidence rates were determined for these cancers by sex, topographical site, and ethnicity, and temporal trends were examined. RESULTS: Age-adjusted incidence rates have been decreasing for OCC and increasing for oropharyngeal cancer in the general population for both sexes, with men having higher incidence rates than women. Ethnic differences were found, with the highest age-adjusted incidence rates for OCC for men in South Asians and for women in Chinese, and with the highest age-adjusted incidence rates for oropharyngeal cancer for men in Chinese and for women in the general population. Differences were also found for OCC topographical sites by sex and ethnicity. CONCLUSIONS: The incidence of oropharyngeal cancer has now surpassed OCC in the British Columbia male population. Ethnic minorities are at higher risk than the general population for both OCC and oropharyngeal cancer for men, and for OCC for women. Cancer 2010;116:2635-44.

Trends in the incidence of human papillomavirus-related noncervical and cervical cancers in Alberta, Canada: a population-based study

“…16 A recent study from British Columbia mirrors the overall Canadian trends. 17 We observed that the increase in incidence of oropharyngeal cancer among men was twice that among women (annual percentage change 3.4 v. 1.5) between 1975 and 2009. Similarly, both Canadian 16 and US 18 data show that the increased incidence of HPV-associated head and neck cancers was greater among men, most notably the younger groups.…”

“…Similarly, both Canadian 16 and US 18 data show that the increased incidence of HPV-associated head and neck cancers was greater among men, most notably the younger groups. In 2 previously reported Canadian studies, 16,17 ethnic minorities appeared to be at higher risk than the general population of both oropharyngeal cancer and oral cavity cancers. In the US, non-Hispanic white and Hispanic populations experienced greater increases in the incidence of HPV-associated head and neck cancers than other groups.…”

The Epidemic of Human Papillomavirus and Oropharyngeal Cancer in a Canadian Population

“…In the United States and Europe, there is compelling evidence that opc is on the rise, and that the increase is primarily a result of increasing rates of In Canada, population-based studies have provided indirect evidence of the phenomenon by demonstrating that the incidence of head-and-neck cancers at hpv-related anatomic sites (oropharynx) are rising and that those of smoking-related sites (for example, oral cavity) are declining 2,11,12 . However, no previous study has performed hpv testing of tumour samples, and thus we have attempted to provide the first direct evidence of this dramatic shift in disease prevalence and demographics.…”

Differences in Expression of EGFR, Ki67 and p-EPK in Oral Cavity Squamous Cell Carcinoma

“…In recent decades, studies have shown that OSCC and OPSCC have different incidence rate trends, etiology, and survival outcome [1]. For instance, human papillomavirus (HPV) is known as an important etiology for OPSCC, especially tonsil cancer.…”