Trends in prostate cancer incidence and mortality in a mid-sized Northeastern Brazilian city

Lima, Carlos Anselmo; Silva, Ângela Maria da; Kuwano, André Yoichi; Rangel, Margareth Rose Uchoa; Macedo-Lima, Matheus

doi:10.1590/s0104-42302013000100006

Cited by 6 publications

(1 citation statement)

References 22 publications

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“…Increase in life expectancy and determination of prostatic specific antigen (PSA) elevated the incidence of PC in the last decades. Prognosis is determined by histologic grade, PSA and digital rectum exam, of which GS is the most important to determine the best treatment for specific - risk groups (1-3).…”

Section: Introductionmentioning

confidence: 99%

The importance of histopathologic review of biopsies in patients with prostate cancer referred to a tertiary uro - oncology center

et al. 2019

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Introduction: In view of the detailed histologic evaluation of prostate cancer (PC), it is usually advisable to provide a “second opinion” to confirm diagnosis. This study aimed to compare the Gleason score (GS) of initial diagnosis versus that of histopathologic review of patients with PC. The secondary objective was to compare initial GS versus histopathologic review versus post - surgical histopathology. Material and methods: Retrospective study based on chart review of patients with PC that attended the Uro - oncology Department of Hospital das Clínicas - UNICAMP - Campinas, Brazil, from April, 2002, to April, 2012. Data were divided in groups: patients with biopsies performed elsewhere, biopsies after pathological review and histopathological results following retropubic radical prostatectomy (RRP). These were evaluated in relation to GS difference using Fleis's Kappa concordance coefficient. Results: 402 PC patients, with a median age of 66 years, were evaluated. Reviewed GS showed worsening, with accuracy of 61.2%, and Kappa concordance value = 0.466. Among 143 patients submitted to surgery, GS varied widely, regarding initial evaluation, review and post - surgical RRP. Joint concordance of evaluations was weak (Kappa = 0.216), mainly due to almost no existence concordance between initial evaluation and following RRP (Kappa = 0.041). Conclusion: There is a great histopathological variation of initial GS versus reviewed GS. There is also a better correlation of reviewed GS and post - surgical GS than with initial GS. The second opinion by an uropathologist improves diagnosis and should be advised for better therapeutic decision.

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Section: Introductionmentioning

confidence: 99%

The importance of histopathologic review of biopsies in patients with prostate cancer referred to a tertiary uro - oncology center

et al. 2019

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Time trends for prostate cancer mortality in Brazil and its geographic regions: An age–period–cohort analysis

Braga

Souza

Cherchiglia

2017

Cancer Epidemiology

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Temporal trend of cancer mortality in a Brazilian state with a medium Human Development Index (1980–2018)

Lima

Siqueira

Moura

et al. 2020

Sci Rep

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Emerging economy countries in epidemiological transition have been especially challenged in the fight against cancer. This was an ecological study that aimed to describe the temporal trend of cancer mortality in a Brazilian northeastern state with a medium Human Development Index using official Brazilian mortality data from 1980 to 2018. We calculated the mortality crude rate (CR) and age-standardized rate (ASR) based on official population counts and estimates. The Joinpoint Regression Program, National Cancer Institute, USA, was used to calculate time trends of cancer mortality. There were 34,214 deaths from cancer, excluding nonmelanoma skin cancer, in Sergipe. The overall cancer mortality ASR was 70.1 and 57.9 per 100,000 men and women, respectively. For the last five years, the leading causes of cancer deaths were prostate (21.3), trachea, bronchus and lung (11.7), stomach (6.5), oral cavity (5.4) and liver and intrahepatic bile ducts (5.1) in males and breast (13.8), trachea, bronchus and lung (6.6), cervix (6.4), colon/rectum (5.8) and central nervous system (3.6) in females. In addition, there was a significant reduction in deaths from ill-defined causes in the series. Our results show that although there has been an increase in cancer mortality rates associated with Western lifestyles, such as prostate, breast and colon/rectum, high rates of cancer related to poverty and infections, such as stomach and cervix, still persist in Sergipe.

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Trends in prostate cancer incidence and mortality in a mid-sized Northeastern Brazilian city

Abstract: There was a sharp increase in incidence rates during the study period, probably due to screening. Mortality rates had a small upward trend, and did not show major changes during the study period.

Cited by 6 publications

References 22 publications

The importance of histopathologic review of biopsies in patients with prostate cancer referred to a tertiary uro - oncology center

The importance of histopathologic review of biopsies in patients with prostate cancer referred to a tertiary uro - oncology center

Time trends for prostate cancer mortality in Brazil and its geographic regions: An age–period–cohort analysis

Temporal trend of cancer mortality in a Brazilian state with a medium Human Development Index (1980–2018)

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