Trends in solitary plasmacytoma, extramedullary plasmacytoma, and plasma cell myeloma incidence and myeloma mortality by racial‐ethnic group, United States 2003‐2016

Abstract

Plasma cell myeloma (also called multiple myeloma), solitary plasmacytoma, and extramedullary plasmacytoma are primarily diseases of the elderly. Evidence suggests an association between excess body weight and multiple myeloma. Few population-based studies have examined incidence and mortality of each site in one study. We analyzed incidence and death rates by site (solitary plasmacytoma, extramedullary plasmacytoma, and multiple myeloma) by gender, age, race/ethnicity, and ruralurban status among adult males and females (aged 20 years or older) in the United States during 2003-2016. Trends were characterized as average annual percentage change (AAPC) in rates. During 2003-2016, overall incidence rates among adults were 0.45 for solitary plasmacytoma, 0.09 for extramedullary plasmacytoma, and 8.47 for multiple myeloma per 100,000 persons. Incidence rates for multiple myeloma increased during 2003-2016 among non-Hispanic whites (AAPC = 1.78%) and non-Hispanic blacks (2.98%) 20-49 years of age; non-Hispanic whites (1.17%) and non-Hispanic blacks (1.24%) 50-59 years of age; and whites non-Hispanic (0.91%), and non-Hispanic blacks (0.96%). During 2003-2016 overall myeloma (extramedullary plasmacytoma and multiple myeloma) death rates among adults was 4.77 per 100,00 persons. Myeloma death rates decreased during 2003-2016 among non-Hispanic white (AAPC = −1.23%) and Hispanic (−1.34%) women; and non-Hispanic white (−0.74%), non-Hispanic American Indian/Alaska Native (−3.05%) men. The US population is projected to become older and will have a larger proportion of persons who have had an earlier and longer exposure to excess body weight. The potential impact of these population changes on myeloma incidence and mortality can be monitored with high-quality cancer surveillance data.

Étude transversale descriptive sur les profils cliniques et paracliniques des gammapathies monoclonales au niveau d´une région agricole du Souss-Massa au Maroc

“…son incidence a augmenté chez les jeunes entre 25 et 49 ans[ 8 ]. Dans une autre étude américaine, l´incidence ajustée à l´âge du myélome multiple chez la population de plus de 20 a été de 5,4 pour 100 000 habitants [ 9 ] .…”

Rare case of anaplastic plasmacytoma in the sinonasal tract

“…Solitary plasmacytomas arise from the plasma cells in the bone marrow while extramedullary plasmacytomas arise from the plasma cells of mucosal surfaces 4 . Both diseases are extremely uncommon, with an incidence of 0.45 and 0.09 per 100 000 individuals, respectively 5 . The median age of diagnosis for both conditions has been reported as 55 years old 3 .…”

“…4 Both diseases are extremely uncommon, with an incidence of 0.45 and 0.09 per 100 000 individuals, respectively. 5 The median age of diagnosis for both conditions has been reported as 55 years old. 3 Extramedullary plasmacytomas most commonly present in the head and neck region, lungs, and gastrointestinal tract.…”

Radiation response of soft‐tissue extramedullary plasmacytoma in multiple myeloma—A case report

“… 7 Although hematogenous metastatic spread occurs more frequently in the skin, liver, kidney, or central nervous system, in our patient the tumor was soft tissue located, which it is suggested to be linked to extension from a skeletal tumor. 8 Recent epidemiological studies 9 have shown a statistically significant increase of EMP involvement in the last decade, and this was due to an increase in detection rates. Modern imaging and immunohistochemical tumor characteristics were found to be responsible for this.…”