Trends in Susceptibility of Vancomycin-Resistant Enterococcus faecium to Tigecycline, Daptomycin, and Linezolid and Molecular Epidemiology of the Isolates: Results from the Tigecycline
            <i>In Vitro</i>
            Surveillance in Taiwan (TIST) Study, 2006 to 2010

Tsai, Hsih Yeh; Liao, Chun-Hsing; Chen, Yen Hsu; Lu, Po Liang; Huang, Cheng; Lu, Chin Te; Chuang, Yin Ching; Tsao, Shih Ming; Chen, Yao Shen; Liu, Yung Ching; Chen, Wei Yu; Jang, Tsrang Neng; Lin, Hsiu Chen; Chen, Chih‐Ming; Shi, Zhi Yuan; Pan, Sung‐Ching; Yang, Jiaying; Kung, Hsiang Chi; Liu, Chun Eng; Liu, Jien Wei; Sun, Weijia; Wang, Lih Shinn; Ko, Wen Chien; Yu, Kwok Woon; Chiang, Ping-Cherng; Lee, Ming Hsun; Lee, Chun Ming; Hsu, Gwo-Jong; Hsueh, Po-Ren

doi:10.1128/aac.00533-12

Cited by 24 publications

(13 citation statements)

References 23 publications

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“…Newer antibiotics, such as linezolid, tygecyclin, daptomycin and quinopristin/dalfopristin have been suggested as an alternative option for treating infections caused by multidrug resistant enterococci (Aksoy and Unal, 2008;Yemisen et al, 2009, Arias et al, 2010Tsai et al, 2012). The results obtained in this study confirmed good activity of linezolid and tygecyclin against both enterococcal species tested and quinopristin/dalfopristin against E. faecium only.…”

Section: Discussionsupporting

confidence: 75%

Prevalence of different enterococcal species isolated from blood and their susceptibility to antimicrobial drugs in Vojvodina, Serbia, 2011-2013

Mira¹,

Deana²,

Zora³

et al. 2014

Afr. J. Microbiol. Res.

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Enterococci are one of the leading causes of nosocomial infections worldwide. Enterococcus faecalis and Enterococcus faecium are the most commonly isolated. The aim of this study was to determine prevalence of these species isolated from blood samples of hospitalized patients and their susceptibility to antibiotics particularly to vancomycin and high concentrations of aminoglycosides. A total of 89 enterococcal strains isolated from blood samples between January 1 st 2011 and August 31 st 2013 were tested. The species identification and susceptibility to antimicrobial drugs were performed using automated VITEK 2 system. The most common species was E. faecalis (55.05%), followed by E. faecium (41.57%). The enterococcal isolates were multidrug resistant with E. faecium resistance to vancomycin of 54.05%, while resistance in E. faecalis was not found. All vancomycin resistant enterococci had VanA phenotype of resistance. Thirty three (89.18%) isolates of E. faecium were high-level gentamycin resistant and 32 (91.4%) were resistant to high concentration of streptomycin, whereas frequency of resistant E. faecalis was 61.2 and 63.04%, respectively. This study shows that resistance in enterococcal species is a serious clinical problem in our hospital and suggests the need for regular susceptibility test and species level identification of enterococcal isolates.

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Section: Discussionsupporting

confidence: 75%

Prevalence of different enterococcal species isolated from blood and their susceptibility to antimicrobial drugs in Vojvodina, Serbia, 2011-2013

Mira¹,

Deana²,

Zora³

et al. 2014

Afr. J. Microbiol. Res.

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“…Linezolid and tigecycline are the alternative option for treatment of vancomycin resistant enterococci (VRE) (Tsai et al, 2012). In this study, the resistance pattern to linezolid among our isolates whether HLAR or non HLAR was very low and none of them were tigecycline resistant.…”

Section: Resultsmentioning

confidence: 71%

A study of high level aminoglycoside resistant enterococci

El-Ghazawy¹,

Okasha²,

Mazloum³

2016

Afr. J. Microbiol. Res.

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“…Early surveillance studies of tigecycline showed no cases of resistant enterococcus, 116 although two case reports of E. faecalis strains with MICs of 2 µg/ml and 6 µg/ml, respectively, have been described 117 , 118 . A more recent study from Taiwan reviewed antimicrobial resistance among 219 VRE isolates and found two isolates with a tigecycline MIC of 0.5, and one isolate with an MIC of 1, with a trend toward increasing tigecycline MIC over time 119 . The mechanism of tigecycline resistance in enterococcus is unknown.…”

Section: Acquired Resistancementioning

confidence: 99%

Intrinsic and acquired resistance mechanisms in enterococcus

Hollenbeck

Rice²

2012

Virulence

629

530

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Enterococci have the potential for resistance to virtually all clinically useful antibiotics. Their emergence as important nosocomial pathogens has coincided with increased expression of antimicrobial resistance by members of the genus. The mechanisms underlying antibiotic resistance in enterococci may be intrinsic to the species or acquired through mutation of intrinsic genes or horizontal exchange of genetic material encoding resistance determinants. This paper reviews the antibiotic resistance mechanisms in Enterococcus faecium and Enterococcus faecalis and discusses treatment options.

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Trends in Susceptibility of Vancomycin-Resistant Enterococcus faecium to Tigecycline, Daptomycin, and Linezolid and Molecular Epidemiology of the Isolates: Results from the Tigecycline In Vitro Surveillance in Taiwan (TIST) Study, 2006 to 2010

Cited by 24 publications

References 23 publications

Prevalence of different enterococcal species isolated from blood and their susceptibility to antimicrobial drugs in Vojvodina, Serbia, 2011-2013

Prevalence of different enterococcal species isolated from blood and their susceptibility to antimicrobial drugs in Vojvodina, Serbia, 2011-2013

A study of high level aminoglycoside resistant enterococci

Intrinsic and acquired resistance mechanisms in enterococcus

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