Trends in the Diagnosis of Vitamin D Deficiency

Basatemür, Emre; Horsfall, Laura; Marston, Louise; Rait, Greta; Sutcliffe, Alastair

doi:10.1542/peds.2016-2748

Cited by 54 publications

(53 citation statements)

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“…Preterm labor in correlation to vitamin D status has been an area of research interest since it affects various pathophysiological pathways that could trigger preterm labor. Vitamin D is well recognized for its non-classical activities such as antioxidant impact, influence on innateimmunological responsiveness and adaptive immunological activities [16][17][18][19][20] .…”

Section: Introductionmentioning

confidence: 99%

Association of vitamin D deficiency in pregnancy and risk of preterm labor

Ibrahim

Abdelrahman

El-Kateb

2019

Evidence Based Women's Health Journal

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Introduction: Prematurity represents around 50-75% of the perinatal mortality causes. It is considered a challenging clinical scenario faced in every day practice. Preterm labor is clinically definedas the beginning of regular uterine contractions accompanying cervical changes before 37 gestational week's completion with or without intact fetal membranes. Aim of the work: To assess the association between vitamin D status and preterm labor. Patients and Methods: 80 pregnant study subjects with singleton pregnancy between 20-28 gestational weeks were followed up for any sign or symptom of preterm labor. Study subjects that completed 37 gestational weeks were considered controls, others delivered before 37 gestational weeks were considered cases. A blood sample was collected from cases and controls and was frozen till reaching our target of PTBs then serum 25(OH) VD was assayed by ELISA. Results: Vitamin D levels were less in the preterm research group in statistically significant fashion (p value =0.000). GA age at delivery was statistically significantly correlated to vitamin D levels in which Pearson correlation = 0.571 (p value =0.000). Vitamin D deficiency was statistically significantly more prevalent in preterm research group ; while vitamin D sufficiency and insufficiency were more prevalent in full term research group in statistically significant manner (p value =0.000). Conclusion: A significant association between vitamin D deficiency in pregnancy and occurrence of preterm labor. Future research studies should in addition consider racial, ethnic differences between study subjects recruited in a comparative manner and seasonal variabilities that could affect vitamin D status.

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Section: Introductionmentioning

confidence: 99%

Association of vitamin D deficiency in pregnancy and risk of preterm labor

Ibrahim

Abdelrahman

El-Kateb

2019

Evidence Based Women's Health Journal

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“…Inflammation sensitive markers were adjusted using the Thurnham correction factors of 0.77 for SF (Thurnham et al, 2010) and 1.14 for RBP (Thurnham, McCabe, Northrop-Clewes, & Nestel, 2003) when there was a concurrent elevated CRP (>5 μg/ml). These cut-offs were applied to determine nutritional status and inflammation in women (a) and children (b): anaemia, (a: Hb < 12 g/dl and b: <11 g/dl (WHO, 2011a)), ID (a: SF < 15 ng/ml or TfR > 3.3 μg/ml and b: SF < 12 ng/ml or TfR > 3.3 μg/ml (WHO/CDC, 2007)), IDA (a: Hb < 12 g/dl plus SF < 15 ng/ml or TfR > 3.3 μg/ml and b: Hb < 11 g/dl plus SF < 12 ng/ml or TfR > 3.3 μg/ml (WHO/CDC, 2007)), iodine deficiency (a and b: UIC < 100 μg/L (WHO, 2013)), vitamin A deficiency (a and b: RBP ≤ 0.70 μmol/L (WHO, 2011b)), vitamin D deficiency (b: vitamin D < 19.6 ng/ml (Basatemur, Horsfall, Marston, Rait, & Sutcliffe, 2017;Braegger et al, 2013) folate insufficiency (a: Folate<3 ng/ml (WHO, 2015)) and inflammation (a and b: CRP > 5 μg/ml (CRP, BioVendor, RAP001 manual); Tables 1 and 2). Body iron stores were calculated from the ratio of TfR to SF according to the following equation by Cook et al: body iron (mg/kg) = −[log 10 (TfR·1000/SF) − 2.8229)]/ 0.1207 (Cook, Flowers, & Skikne, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…Abbreviations: CRP, C-reactive protein; Hb, haemoglobin; ID, iron deficiency; IDA, iron deficiency anaemia;SF, serum ferritin; TfR, transferrin receptor; UIC, urinary iodine concentration. (Basatemur et al, 2017;Braegger et al, 2013) CRP > 5 μg/ml…”

Section: Discussionmentioning

confidence: 99%

Nutritional status of Tajik children and women: Transition towards a double burden of malnutrition

Barth‐Jaeggi

Zandberg

Bahruddinov³

et al. 2019

Maternal & Child Nutrition

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The double burden of malnutrition, an emerging concern in developing countries, can exist at various levels: individual, household, and population. Here, we explore the nutritional status of Tajik women (15–49 years) and children (5–59 months) focusing on overweight/obesity along with undernutrition (underweight, stunting, and micronutrient deficiencies). For this, nutritional markers (haemoglobin (Hb), transferrin receptor (TfR), serum ferritin (Sf), retinol binding protein (RBP), vitamin D, serum folate, and urinary iodine), height, and weight were assessed from 2,145 women and 2,149 children. Dietary intake, weaning, and breastfeeding habits were recorded using a 24‐hr recall and a questionnaire. Overweight (24.5%) and obesity (13.0%) are increasing among Tajik women compared with previous national surveys (2003 and 2009). Prevalence of iron deficiency and anaemia was 38.0% and 25.8%, respectively; 64.5% of women were iodine deficient, 46.5% vitamin A deficient, and 20.5% had insufficient folate levels. Women in rural areas had significantly lower iron status and body mass index and higher iodine intake compared with urban areas; 20.9% of children were stunted, 2.8% wasted, 6.2% underweight, 52.4% iron deficient, and 25.8% anaemic; all more prominent in rural areas. Dietary diversity was higher among urban women. Intraindividual or household double burden was not seen. In summary, double burden of malnutrition constituted an increase in overweight among women, especially in urban areas, and persisting levels of undernutrition (stunting, iron, and vitamin A deficiency), predominately in rural areas. A holistic, innovative approach is needed to improve infant and young children feeding and advise mothers to maintain an adequate diet.

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“…Socio-demographic factors independently associated with higher rates of diagnosis included; older children, female sex in children aged ≥10 years old, and male sex in children aged <5 years old. [32] Developed countries were concerned with this issue many decades ago, and recently vitamin D deficiency and insufficiency become a growing public health concern among Egyptians, as it became notable among children and its consequences on their general health status.…”

Section: Discussionmentioning

confidence: 99%

Effect of Vitamin D Supplementation on Glycemic Control in Children with Type 1 Diabetes Mellitus: A Randomized Clinical Trial

El-Sayed¹,

Raaouf²,

Laimon³

2019

AJNR

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Background: Vitamin D endocrine system is a potential immune system modulator and has been implicated in the pathogenesis of several autoimmune diseases including type 1 diabetes mellitus. A relationship between type 1 diabetes and vitamin D deficiency has been reported, in which low vitamin D levels are shown to have a negative effect on beta-cell function. The aims of the study were to investigate vitamin D status and to evaluate the effect of vitamin D3 supplementation on glycemic control in children with type 1 diabetes. Method: A randomized clinical trial including 80 children who were newly diagnosed with type 1 diabetes and randomly assigned into either control or intervention arm was used. Vitamin D status and Glycohemoglobin (HbA1c) were assessed initially for both the study two arms. Diabetic children of the intervention arm who had vitamin D deficiency and insufficiency were treated with 4000 units of vitamin D3 and calcium (500 mg/day) in oral liquid form. After the study interference (3 months later), HbA1C was measured again for both arms as an indicator for glycemic control. Differences in mean±SD HbA1C and body mass index were assessed before and after the study. Results: The mean of body mass index in intervention arm was 14.77±3.49, while in control arm was 17.84±3.87, with statistically significant deference between two arms P<.001. Furthermore, the mean change in HbA1c levels in intervention arm was 6.78±1.94 compared with 7.03±1.83 in control arm, with no statistically significant deference detected between children of the study two arms P<.460. Conclusion: Vitamin D3 supplement on the clinical base improves glycemic control in pediatrics with type I diabetes mellitus and vitamin D deficiency.

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Trends in the Diagnosis of Vitamin D Deficiency

Abstract: There has been a marked increase in diagnosis of vitamin D deficiency in children over the past decade. Future research should explore the drivers for this change in diagnostic behavior and the reasons prompting investigation of vitamin D status in clinical practice.

Cited by 54 publications

References 45 publications

Association of vitamin D deficiency in pregnancy and risk of preterm labor

Association of vitamin D deficiency in pregnancy and risk of preterm labor

Nutritional status of Tajik children and women: Transition towards a double burden of malnutrition

Effect of Vitamin D Supplementation on Glycemic Control in Children with Type 1 Diabetes Mellitus: A Randomized Clinical Trial

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