Trends in the incidence and mortality of systemic lupus erythematosus, 1950-1992

Km, Uramoto; Cj, Michet; Thumboo, Julian; Sunku, Jayasimha; Wm, O'Fallon; Se, Gabriel

doi:10.1002/1529-0131(199901)42:1<46::aid-anr6>3.0.co;2-2

Cited by 428 publications

(266 citation statements)

References 21 publications

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“…A population-based study from Rochester, Minnesota, ascertained 48 SLE cases over a 12-year period, and estimated the 1993 SLE prevalence to be 12.2 cases per 10,000 people, adjusted by age and sex to the 1970 US white population (28). In the Canadian province of Manitoba, a prevalence estimate based on medical documentation was 2.1 cases per 10,000 for the general population, and 4.2 cases per 10,000 for the Aboriginal population (8).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of systemic lupus erythematosus and systemic sclerosis in the First Nations population of Alberta, Canada

Barnabe

Joseph

Bélisle

et al. 2011

Arthritis Care & Research

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Objective. To estimate the population-based prevalence of systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) in Alberta, Canada, stratified by First Nations status. Methods. Physician billing claims and hospitalization data for the province of Alberta (1994 -2007) were used to ascertain cases of SLE and SSc using 3 case definitions. A latent class Bayesian hierarchical regression model was employed to account for the imperfect sensitivity and specificity of billing and hospitalization data in case ascertainment. We accounted for demographic factors, estimating prevalence rates for the First Nations and non-First Nations populations by sex, age group, and location of residence (urban/rural). Results. Our model estimated the prevalence of SLE in Alberta to be 27.3 cases per 10,000 females (95% credible interval [95% CrI] 25.9 -28.8) and 3.2 cases per 10,000 males (95% CrI 2.6 -3.8). The overall prevalence of SSc in Alberta was 5.8 cases per 10,000 females (95% CrI 5.1-6.5) and 1.0 case per 10,000 males (95% CrI 0.7-1.4). First Nations females over 45 years of age had twice the prevalence of either SLE or SSc relative to non-First Nations females. There was also a trend toward higher overall SLE prevalence in urban dwellers, and higher overall SSc prevalence in rural residents. Conclusion. First Nations females older than 45 years of age have an increased prevalence of either SLE or SSc. This may reflect a true predominance of autoimmune rheumatic diseases in this demographic, or may indicate systematic differences in health care delivery.

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Section: Discussionmentioning

confidence: 99%

Prevalence of systemic lupus erythematosus and systemic sclerosis in the First Nations population of Alberta, Canada

Barnabe

Joseph

Bélisle

et al. 2011

Arthritis Care & Research

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“…Studies from other regions give conflicting data. In the French West Indies no changes in SLE incidence have occurred 24 , while the Mayo Clinic in Rochester, MN, USA, describes a tripling of SLE incidence in the period 1950-92 9 . The Rochester population has a strong Nordic background and the overall incidence rate for the study was 3.0/100,000 9 , similar to our data, so the increase observed in Rochester may be a catchup effect.…”

Section: Discussionmentioning

confidence: 99%

“…There are considerable regional differences in the epidemiology of SLE, with the lowest incidence rates observed in Caucasian populations [3][4][5][6] . There has been a trend towards an increased incidence and prevalence of SLE for Caucasian cohorts in the USA [7][8][9] , while the incidence has been stable in southern Sweden 10 .…”

mentioning

confidence: 99%

The Influence of the 1997 Updated Classification Criteria for Systemic Lupus Erythematosus: Epidemiology, Disease Presentation, and Patient Management

Eilertsen¹,

Becker-Merok²,

Nossent³

2009

J Rheumatol

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ABSTRACT. Objective. The 1997 update of the American College of Rheumatology classification criteria (ACR97) for systemic lupus erythematosus (SLE) has not been validated. We determined to what extent their introduction influenced the epidemiology and clinical characteristics of the disease in northern Norway. Methods. Annual incidence and point-prevalence rates, clinical manifestations, and outcome were determined in an inception cohort of patients with SLE in northern Norway, included between 1996 and 2006, using ACR97 criteria (97acr). These findings were compared with a cohort from the same area enrolled 1978-1995 using the 1982 revised criteria ACR82 (82acr). Results. The mean annual incidence of SLE was 3.00 for cohort 97acr (n = 58) versus 2.63 for cohort 82acr (n = 81) (p = 0.5). All patients in the 97acr cohort also fulfilled the 1982 criteria; however, significantly fewer patients presented with discoid rash [odds ratio (OR) 0.31)], arthritis (OR 0.24), renal (OR 0.28) or hematological disorder (OR 0.27), and significantly more with anti-dsDNA (OR 2.57) and antiphospholipid antibodies (OR 27.9). Initial treatment with intravenous pulse methylprednisolone (OR 9.23), azathioprine (OR 6.32), and low-dose aspirin (OR 20.9) was increased in cohort 97acr. Five-(95.2%) and 10-year survival (91.9%) rates were also improved for cohort 97acr. Conclusion. The ACR97 criteria set has construct validity compared to the ACR82 criteria set. SLE incidence remains unchanged in northern Norway, but a significant reduction of renal disease and further improvements in survival rates occurred simultaneously with increased serological surveillance with ELISA-based assays and early immunosuppressive and anticoagulant therapy.

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“…20-50/100000 und einer geschätzten Inzidenz von 5/100000 pro Jahr ist der SLE die häufigste systemische Bindegewebserkrankung in Deutschland (20). Die Ursache ist nicht vollständig geklärt.…”

Section: Epidemiologie äTiopathogeneseunclassified

Systemic lupus erythematosus

Fischer-Betz¹,

Herzer²,

Schneider³

2005

Dtsch med Wochenschr

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Trends in the incidence and mortality of systemic lupus erythematosus, 1950-1992

Abstract: Over the past 4 decades, the incidence of SLE has nearly tripled, and there has been a statistically significant improvement in survival. These findings are likely due to a combination of improved recognition of mild disease and better approaches to therapy.

Cited by 428 publications

References 21 publications

Prevalence of systemic lupus erythematosus and systemic sclerosis in the First Nations population of Alberta, Canada

Prevalence of systemic lupus erythematosus and systemic sclerosis in the First Nations population of Alberta, Canada

The Influence of the 1997 Updated Classification Criteria for Systemic Lupus Erythematosus: Epidemiology, Disease Presentation, and Patient Management

Systemic lupus erythematosus

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