Trends in the Incidence of Biopsy-Proven Glomerular Diseases in the Adult Population in Central Poland in the Years 1990-2010

Kurnatowska, Ilona; Jędrzejka, Dorota; Małyska, Aneta; Wągrowska-Danilewicz, Małgorzata; Danilewicz, Marian; Nowicki, Michał

doi:10.1159/000334418

Cited by 25 publications

(27 citation statements)

References 29 publications

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“…[6][7] In current analysis in 27 cases the microscopic findings were close to normal histology. This is in concordance with study conducted by Usta et al [8] on 55 renal autopsy in which 23 cases exhibited almost normal histology.…”

Section: Discussionsupporting

confidence: 71%

The Histomorphological Spectrum of Renal Lesions in an Autopsy Study

Sandhu

Puri

Singh

2017

APALM

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Background: Autopsy provides normal as well as diseased human tissue for morphologic studies, for establishment of cell and organ culture as well for xenotransplantation. It provides the opportunity to discover new diseases, to evaluate toxic effects of drugs and therapies. The kidneys are often affected by chronic inflammatory lesions, neoplasms , toxic effects of various drugs and metabolic disorders. Material and Methods:This was a five year study from January 2011 to December 2015 in our department of pathology. The kidneys of medico legal autopsies performed during these years were subjected to our study. After excluding 30 cases of severely damaged tissue, 120 cases of well preserved renal medico legal autopsies were included in our study. The stained microscopic sections were examined by two histopathologists independently.Results: Seventy five of the 120 autopsies were males, while 45 were females. In 27 (22.5%) cases, the microscopic morphology was close to normal histology. Remaining 93(77.5%) cases had a nephropathological findings The percentage of non glomerular nephropathies (60.8%) was higher as compared to that of glomerular lesions (16%). 20 (16% ) cases exhibited glomerular alterations such focal global glomerular sclerosis, segmental glomerular sclerosis, nodular mesangial sclerosis, basement thickening and mesangial cellular proliferation. Tubular and interestium lesions were observed in 34.16% which included acute tubular necrosis, chronic pyelonephritis and tubercular pyelonephritis. Renal arteriosclerosis was observed in 25% cases. Renal cell carcinoma was incidentally detected in1.6% Conclusion: Our study provided satisfactory data in respect to morphological spectrum of various renal lesions in autopsy.

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Section: Discussionsupporting

confidence: 71%

The Histomorphological Spectrum of Renal Lesions in an Autopsy Study

Sandhu

Puri

Singh

2017

APALM

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“…The occurrence of FSGS in our center (16.3%) is comparable with the results of other Polish centers (17.3%) and the USA (17%), but higher than in studies from other European countries, such as Estonia (7.3%) or the Czech Republic (10.8%) [7,10,13,15]. The reasons for the different epidemiologic patterns in renal biopsy are not completely clear.…”

Section: Discussionsupporting

confidence: 76%

“…is less frequent in some American and Asian countries [4,17]. However, it should be noted that according to data from Central Poland the number of cases of IgAN diagnosed in kidney biopsy specimens increased systematically together with an increase of performing DIF and eventually reached 100% of MesGN diagnoses [10]. Therefore, MesGN is currently rarely diagnosed and hardly encountered in recent literature data.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, data from European registries point to IgA nephropathy (IgAN) as the most common GN [6,7,8], although there are reports suggesting significant differences in the epidemiology of GN between Eastern and Western Europe, with the higher prevalence of other than IgAN causes of GN in the former region [9]. A recent study from central Poland showed the results of retrospective analysis of 746 consecutive native kidney biopsies, with mesangioproliferative GN (MesGN) including IgAN remaining the most frequent type of GN [10]. However, considering the number of renal biopsies in relation to the general Polish population, there are still scarce data regarding the frequency and distribution pattern of different forms of GN.…”

Section: Introductionmentioning

confidence: 99%

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Patterns of glomerular disease based on 4-year kidney biopsy material analyzed by light microscopy and immunofluorescence: a retrospective single-center analysis in Poland

Olewicz‐Gawlik¹,

Sikorska²,

Pluto-Prądzyńska³

et al. 2016

pjp

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The aim of this study was to assess the epidemiology of different patterns of chronic glomerular diseases based on clinical, histopathological and immunofluorescent findings of glomerulonephritis patients hospitalized in the Department of Nephrology, Transplantology and Internal Diseases in Poznan between January 2009 and December 2012. We retrospectively studied 418 patients who had been subjected to renal biopsies. Data on serum creatinine concentration, 24 h proteinuria, arterial hypertension, diabetes mellitus, and histological and immunofluorescent findings were collected. The patients' mean age was 42 ±15. The male sex prevailed (53.1%). Immunoglobulin A nephropathy was the most common finding (18.9%), followed by focal segmental glomerulosclerosis (16.3%), membranous glomerulonephritis (10.1%), lupus nephritis (8.4%), extracapillary glomerulonephritis (3.3%) and membranoproliferative glomerulonephritis (2.6%). In 69 (16.5%) patients the biopsy was non-informative or non-diagnostic. Patients with membranous nephropathy presented the highest frequency of nephrotic syndrome (71.4%), followed by membranoproliferative glomerulonephritis and focal segmental glomerulosclerosis. Combined analysis of the clinical, histopathological and immunofluorescent findings in glomerulonephritis patients based on a single center's data can provide important epidemiological findings.

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“…In addition, data from local or limited national registries of renal biopsy have been reported from South Korea [10,11], Bahrain [12,13], Brazil [14], Romania [15], China [16], Finland [17], Serbia [18], Pakistan [19] and Belgium [20]. Finally, there are also reports that include epidemiological data only on glomerular diseases from Australia [21], Macedonia [22], France [23], USA [24], Iran [25], Germany [26], Lebanon [27], Peru [28] and Poland [29]. In this study we describe the frequency and clinicopathological correlations of biopsy-proven native renal diseases in Croatian adults observed over past 15 years.…”

Section: Introductionmentioning

confidence: 99%

Epidemiologic data of adult native biopsy-proven renal diseases in Croatia

et al. 2013

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PURPOSE: There is a paucity of epidemiological data on biopsy-proven renal disease in Croatia. The purpose of this report is a review of clinical and histological data, over a period of 15 years, from the single biggest adult native renal biopsy centre in Croatia.METHODS: This report includes data from 922 adult native renal biopsies in patients referred from the whole country and performed in our centre from 1996 till February 2012. Data on age, gender, serum creatinine, urine sediment, 24-hour proteinuria, clinical syndrome and histological diagnosis were collected and analyzed retrospectively. In all patients light, immunofluorescence and electron microscopic analysis was performed.RESULTS: The median age of the patients was 48 years (interquartile range 36-59 years), and the majority of patients were men (57.8%). The most common indication for renal biopsy was nephrotic syndrome (40.3%) followed by asymptomatic urinary abnormalities (31.7%). The most common biopsy-proven renal disease in total was IgA glomerulonephritis (19.3%), followed by FSGS (15.8%) and membranous glomerulonephritis (9.2%). In men similar results were found, while in women the most common were hereditary nephritis (13.4%), FSGS (12.9%) and connective tissue disease-related glomerular disorders (11.6%).CONCLUSION: The presented data are an important contribution to the better understanding of the epidemiology of biopsy-proven renal disease in Croatia and Europe throughout comparison with other registry data. This data should be the basis for the formation of Croatian Registry of Renal Biopsies.

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Trends in the Incidence of Biopsy-Proven Glomerular Diseases in the Adult Population in Central Poland in the Years 1990-2010

Cited by 25 publications

References 29 publications

The Histomorphological Spectrum of Renal Lesions in an Autopsy Study

The Histomorphological Spectrum of Renal Lesions in an Autopsy Study

Patterns of glomerular disease based on 4-year kidney biopsy material analyzed by light microscopy and immunofluorescence: a retrospective single-center analysis in Poland

Epidemiologic data of adult native biopsy-proven renal diseases in Croatia

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