Trends in the incidence of renal replacement therapy for end-stage renal disease in Europe, 1990-1999

Stengel, Bénédicte; Billon, S.; Dijk, Paul C. W. van; Jager, Kitty J.; Dekker, Friedo W.; Simpson, Keith; Briggs, J. D.

doi:10.1093/ndt/gfg233

Cited by 225 publications

(162 citation statements)

References 18 publications

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“…The incidence rate remained stable in the period, as has occurred in the USA and in several developed countries. 20 The small In Brazil, men represent the majority (57%) of new patients, a fi nding similar to international studies. 8,9,19 The main cause of CKD identifi ed by our study was hypertension, followed by diabetes, in contrast to other studies performed in countries of America, 6,8,9,19 in which diabetes was identifi ed as the leading cause.…”

Section: Discussionsupporting

confidence: 68%

Perfil epidemiológico dos pacientes em terapia renal substitutiva no Brasil, 2000-2004

et al. 2010

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OBJECTIVE:To describe the clinical and epidemiological profi le of patients under renal replacement therapies, identifying risk factors for death. METHODS:This is a non-concurrent cohort study of data for 90,356 patients in the National Renal Replacement Therapies Database. A deterministicprobabilistic linkage was performed using the Authorization System for High Complexity/Cost Procedures and the Mortality Information System databases. All patients who started dialysis between 1/1/2000 and 12/31/2004 were included and followed until death or the end of 2004. Age, sex, region of residence, primary renal disease and causes of death were analyzed. A proportional hazards model was used to identify factors associated with risk of death. RESULTS:The prevalence of patients under renal replacement therapies increased an average of 5.5%, while incidence remained stable during the period. Hemodialysis was the predominant initial modality (89%). The patients were majority male with mean age 53 years, residents of the Southeast region and presented unknown causes as the main cause of chronic renal disease, followed by hypertension, diabetes and glomerulonephritis. Of these patients, 42% progressed to death and 7% underwent kidney transplantation. The patients on peritoneal dialysis were older and had higher prevalence of diabetes. The death rate varied from 7% among transplanted patients to 45% among non-transplanted patients. In the fi nal Cox proportional hazards model, the risk of mortality was associated with increasing age, female sex, having diabetes, living in the North and Northeast region, peritoneal dialysis as a fi rst modality and not having renal transplantation. CONCLUSIONS:There was an increased prevalence of patients on renal therapy in Brazil. Increased risk of death was associated with advanced age, diabetes, the female sex, residents of the North and Northeast region and lack of renal transplant.

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Section: Discussionsupporting

confidence: 68%

Perfil epidemiológico dos pacientes em terapia renal substitutiva no Brasil, 2000-2004

et al. 2010

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“…[6] The results indicate that the S. cordatum leaf extracted triterpene, oleanolic acid (OA) not only has the potential to lower blood pressure in diabetes, but may also have beneficial effects on the kidney function. Long-term diabetes mellitus complications often include compromised kidney function [22] and elevated blood pressure. [23] The spectra of S.cordatum leaf extracted OA elucidated using 1 H-and 13 C-NMR compared with previously reported data of oleanolic acid (see Figure 5).…”

Section: Discussionmentioning

confidence: 99%

Renal Effects of Plant-Derived Oleanolic Acid in Streptozotocin-Induced Diabetic Rats

et al. 2009

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Previous studies from our laboratories indicate that the antidiabetic effects of Syzygium cordatum (Hochst.) [Myrtaceae] leaf extract in streptozotocin-induced diabetic rats may be attributed in part to mixtures of triterpenes, oleanolic acid (3ß-hydroxy-olea-12-en-28-oic acid, OA) and ursolic acid (3ß -hydroxyl-urs-12-en-28-oic acid, UA). For the bioactive compounds to have potential in diabetes management, they should alleviate or prevent complications of diabetes mellitus, kidney function, and cardiovascular disorders. This study was, therefore, designed to assess whether S. cordatum leaf derived OA influenced renal function evaluated by the ability to increase urinary Na + outputs parameters and creatinine clearance (Ccr) of streptozotocin (STZ)-induced diabetic rats. Extraction and fractionation of S. cordatum powdered leaf ethyl acetate-solubles (EAS) yielded mixtures of OA/UA and methyl maslinate/methyl corosolate. Recrystallization of OA/UA mixture using ethanol afforded OA, the structure of which was confirmed by NMR spectroscopy ( 1 H & 13 C). Acute effects of OA on kidney function and mean arterial blood pressure (MAP) were investigated in anesthetized rats challenged with hypotonic saline after a 3.5-h equilibration for 4h of 1 h control, 1.5 h treatment, and 1.5 h recovery periods. OA was added to the infusate during the treatment period. Chronic effects of OA were studied in individually caged rats treated twice daily with OA (60 mg/kg, p.o.) for five weeks. By comparison with respective control animals administration, OA significantly increased Na + excretion rates of non-diabetic and STZ-induced diabetic rats without affecting urine flow, K + and Cl − rates. At the end of five weeks, OA treatment significantly (p < 0.05) increased Ccr in non-diabetic (2.88 ± 0.14 vs. 3.71 ± 0.30 ml/min) and STZdiabetic rats (1.81 ± 0.32 vs. 3.07 ± 0.16 ml/min) with concomitant reduction of plasma creatinine concentration (n = 6 in all groups). OA also caused significant decreases in MAP in nondiabetic and STZ-induced diabetic rats. These findings suggest that OA may have beneficial effects on some processes associated with renal derangement of STZ-induced diabetic rats.

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“…T he steady rise in the number of patients who receive treatment for ESRD is a worldwide public health problem (1)(2)(3)(4). Healthy People 2010 lists reducing ESRD incidence as a national health priority.…”

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confidence: 99%

Exploring Secular Trends in the Likelihood of Receiving Treatment for End-Stage Renal Disease

Hsu¹,

Go²,

McCulloch³

et al. 2007

Clinical Journal of the American Society of Nephrology

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There is a limited understanding of the forces that drive the steady rise in the number of patients who receive treatment for ESRD. It was hypothesized that this is not simply due to increasing prevalence of chronic kidney disease (CKD) or changes in renal failure risk factors in the population from which ESRD cases develop. A noncurrent cohort study was conducted to quantify the change over time (

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Trends in the incidence of renal replacement therapy for end-stage renal disease in Europe, 1990-1999

Cited by 225 publications

References 18 publications

Perfil epidemiológico dos pacientes em terapia renal substitutiva no Brasil, 2000-2004

Perfil epidemiológico dos pacientes em terapia renal substitutiva no Brasil, 2000-2004

Renal Effects of Plant-Derived Oleanolic Acid in Streptozotocin-Induced Diabetic Rats

Exploring Secular Trends in the Likelihood of Receiving Treatment for End-Stage Renal Disease

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