Trends in the occurrence of MRSA strains in Upper Austria from 2006 to 2009

Krziwanek, K.; Metz-Gercek, Sigrid; Mittermayer, H.

doi:10.1111/j.1469-0691.2010.03376.x

Cited by 11 publications

(11 citation statements)

References 12 publications

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“…However, a recent meta-analysis retrieving 1,004 publications covering the three continents showed that USA300 CA-MRSA is far from expanding on the various continents ( 68 ) and is instead declining in many countries ( 33 , 34 ). Observations on the European continent suggest that the USA300-NA lineage, which has been described for decades as having a rather low prevalence and, according to our study, was imported into France on multiple instances many years ago, is apparently not expanding ( 32 , 34 , 44 , 69 , 70 ). Overall, it appears that the USA300-NA clone is behaving like many other MRSA clones, in particular, HA-MRSA, for which a model of cyclic periods of expansion, equilibrium, and decline has been observed ( 56 , 71 – 76 ).…”

Section: Discussionsupporting

confidence: 50%

Demography and Intercontinental Spread of the USA300 Community-Acquired Methicillin-Resistant Staphylococcus aureus Lineage

Glaser

Martins-Simões

Villain

et al. 2016

mBio

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Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) was recognized worldwide during the 1990s; in less than a decade, several genetically distinct CA-MRSA lineages carrying Panton-Valentine leukocidin genes have emerged on every continent. Most notably, in the United States, the sequence type 18-IV (ST8-IV) clone known as USA300 has become highly prevalent, outcompeting methicillin-susceptible S. aureus (MSSA) and other MRSA strains in both community and hospital settings. CA-MRSA bacteria are much less prevalent in Europe, where the European ST80-IV European CA-MRSA clone, USA300 CA-MRSA strains, and other lineages, such as ST22-IV, coexist. The question that arises is whether the USA300 CA-MRSA present in Europe (i) was imported once or on very few occasions, followed by a broad geographic spread, anticipating an increased prevalence in the future, or (ii) derived from multiple importations with limited spreading success. In the present study, we applied whole-genome sequencing to a collection of French USA300 CA-MRSA strains responsible for sporadic cases and micro-outbreaks over the past decade and United States ST8 MSSA and MRSA isolates. Genome-wide phylogenetic analysis demonstrated that the population structure of the French isolates is the product of multiple introductions dating back to the onset of the USA300 CA-MRSA clone in North America. Coalescent-based demography of the USA300 lineage shows that a strong expansion occurred during the 1990s concomitant with the acquisition of the arginine catabolic mobile element and antibiotic resistance, followed by a sharp decline initiated around 2008, reminiscent of the rise-and-fall pattern previously observed in the ST80 lineage. A future expansion of the USA300 lineage in Europe is therefore very unlikely.

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Section: Discussionsupporting

confidence: 50%

Demography and Intercontinental Spread of the USA300 Community-Acquired Methicillin-Resistant Staphylococcus aureus Lineage

Glaser

Martins-Simões

Villain

et al. 2016

mBio

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“…The ST152 clone seems to be frequent and widespread in West Africa (40–60% of all strains) both in the community and in hospital settings (Ruimy et al, 2008 ; Shittu et al, 2012 ; Kraef et al, 2015 ). This clone has also been detected in Europe (Jappe et al, 2008 ; Perez-Roth et al, 2010 ; Krziwanek et al, 2011 ), Turkey (Sudagidan and Aydin, 2010 ), and Haiti (Rosenthal et al, 2014 ).…”

Section: Discussionmentioning

confidence: 88%

High Nasal Carriage Rate of Staphylococcus aureus Containing Panton-Valentine leukocidin- and EDIN-Encoding Genes in Community and Hospital Settings in Burkina Faso

et al. 2016

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The objectives of the present study were to investigate the rate of S.aureus nasal carriage and molecular characteristics in hospital and community settings in Bobo Dioulasso, Burkina Faso. Nasal samples (n = 219) were collected from 116 healthy volunteers and 103 hospitalized patients in July and August 2014. Samples were first screened using CHROMagar Staph aureus chromogenic agar plates, and S. aureus strains were identified by mass spectrometry. Antibiotic susceptibility was tested using the disk diffusion method on Müller-Hinton agar. All S. aureus isolates were genotyped using DNA microarray. Overall, the rate of S. aureus nasal carriage was 32.9% (72/219) with 29% in healthy volunteers and 37% in hospital patients. Among the S. aureus isolates, only four methicillin-resistant S. aureus (MRSA) strains were identified and all in hospital patients (3.9%). The 72 S. aureus isolates from nasal samples belonged to 16 different clonal complexes, particularly to CC 152-MSSA (22 clones) and CC1-MSSA (nine clones). Two clones were significantly associated with community settings: CC1-MSSA and CC45-MSSA. The MRSA strains belonged to the ST88-MRSA-IV or the CC8-MRSA-V complex. A very high prevalence of toxinogenic strains 52.2% (36/69), containing Panton-Valentine leucocidin- and EDIN-encoding genes, was identified among the S. aureus isolates in community and hospital settings. This study provides the first characterization of S. aureus clones and their genetic characteristics in Burkina Faso. Altogether, it highlights the low prevalence of antimicrobial resistance, high diversity of methicillin-sensitive S. aureus clones and high frequency of toxinogenic S. aureus strains.

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“…Isolates consistent with USA300 are the most common PVL-positive MRSA strains in Spain, and, among these, USA300-LV is predominant [41,44,48,51]. Unlike the situation in Canada, USA300 generally makes up only a small proportion of all clinical MRSA isolates in Europe, ranging from 0.8% to 3.5% in various countries [39,44,45,47,[51][52][53][54][55].…”

Section: Latin America and The Caribbeanmentioning

confidence: 99%

USA300 abroad: global spread of a virulent strain of community-associated methicillin-resistant Staphylococcus aureus

Nimmo

2012

Clinical Microbiology and Infection

185

127

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Clin Microbiol Infect Abstract The epidemic of USA300‐0114 methicillin‐resistant Staphylococcus aureus (MRSA) in the USA has been remarkable for its virulence and for its ability to cause infections in both the community and healthcare settings. Although it has mainly been associated with skin and soft tissue infections, particularly furunculosis, it has also caused severe life‐threatening conditions such as necrotizing pneumonia, osteomyelitis, and septic arthritis. This strain or a closely related Latin American variant has now spread to multiple countries on five continents, where associated clinical and epidemiological features have been in keeping with those seen in the USA. Furthermore, it has become the dominant community‐associated MRSA strain in five countries. It is now a major international epidemic strain, but whether it will supplant established community‐associated strains in other countries remains to be seen.

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Trends in the occurrence of MRSA strains in Upper Austria from 2006 to 2009

Cited by 11 publications

References 12 publications

Demography and Intercontinental Spread of the USA300 Community-Acquired Methicillin-Resistant Staphylococcus aureus Lineage

Demography and Intercontinental Spread of the USA300 Community-Acquired Methicillin-Resistant Staphylococcus aureus Lineage

High Nasal Carriage Rate of Staphylococcus aureus Containing Panton-Valentine leukocidin- and EDIN-Encoding Genes in Community and Hospital Settings in Burkina Faso

USA300 abroad: global spread of a virulent strain of community-associated methicillin-resistant Staphylococcus aureus

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