Trends in the Surgical Treatment of Articular Cartilage Lesions in the United States: An Analysis of a Large Private-Payer Database Over a Period of 8 Years

McCormick, Frank; Harris, Joshua D.; Abrams, Geoffrey D.; Frank, Rachel M.; Gupta, Anil K.; Hussey, Kristen; Wilson, Hillary; Bach, Bernard R.; Cole, Brian J.

doi:10.1016/j.arthro.2013.11.001

Cited by 198 publications

(173 citation statements)

References 14 publications

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“…Articular cartilage defects are common in patients undergoing arthroscopy [15]; however, the most frequently used US treatments are designed to address symptoms without restoring hyaline cartilage [26]. Cartilage restoration techniques have evolved in the last 20 years, from microfracture to autologous chondrocyte transplantation, and matrix-assisted chondrocyte transplantation is available outside the United States.…”

Section: Discussionmentioning

confidence: 99%

“…The most often used treatment in the United States is palliative chondroplasty followed by marrow stimulation techniques such as microfracture with restorative techniques, including autologous chondrocyte transplantation with osteochondral transfer being much less common [26]. Microfracture relies on perforation of the subchondral bone of the articular cartilage defect, leading to the egress of marrow components, including stem cells and growth factors to stimulate repair [12,39].…”

Section: Introductionmentioning

confidence: 99%

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What Is the Effect of Matrices on Cartilage Repair? A Systematic Review

Wylie

Hartley

Kapron

et al. 2015

Clinical Orthopaedics &Amp; Related Research

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Background Articular cartilage has minimal endogenous ability to undergo repair. Multiple chondral restoration strategies have been attempted with varied results. Questions/purposes The purpose of our review was to determine: (1) Does articular chondrocyte transplantation or matrix-assisted articular chondrocyte transplantation provide better patient-reported outcomes scores, MRI morphologic measurements, or histologic quality of repair tissue compared with microfracture in prospective comparative studies of articular cartilage repair; and (2) which available matrices for matrix-assisted articular chondrocyte transplantation show the best patient-reported outcomes scores, MRI morphologic measurements, or histologic quality of repair tissue? Methods We conducted a systematic review of PubMed, CINAHL, and MEDLINE from March 2004 to February 2014 using keywords determined to be important for articular cartilage repair, including ''cartilage'', ''chondral'', ''cell source'', ''chondrocyte'', ''matrix'', ''augment'', ''articular'', ''joint'', ''repair'', ''treatment'', ''regeneration'', and ''restoration'' to find articles related to cell-based articular cartilage repair of the knee. The articles were reviewed by two authors (JDW, MKH), our study exclusion criteria were applied, and articles were determined to be relevant (or not) to the research questions. The Methodological Index for Nonrandomized Studies (MIN-ORS) scale was used to judge the quality of nonrandomized manuscripts used in this review and the Jadad score was used to judge the quality of randomized trials. Seventeen articles were reviewed for the first research question and 83 articles were reviewed in the second research question from 301 articles identified in the original systematic search. The average MINORS score was 9.9 (62%) for noncomparative studies and 16

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

What Is the Effect of Matrices on Cartilage Repair? A Systematic Review

Wylie

Hartley

Kapron

et al. 2015

Clinical Orthopaedics &Amp; Related Research

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“…The incidence of symptomatic focal cartilage lesions is increasing annually 6 ; however, the optimal method of treatment for these lesions continues to be debated. Treatment options range from palliative (chondroplasty or debridement) to repair (microfracture) to restoration techniques (OATs, ACI, osteochondral allograft, or synthetic scaffold plugs), with widely variable reports of success.…”

Section: Discussionmentioning

confidence: 99%

Acute Delamination of Commercially Available Decellularized Osteochondral Allograft Plugs

et al. 2016

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Articular cartilage injuries, and corresponding surgical procedures, are occurring with increasing frequency as identified by a review of recent surgical trends. Concerns have grown in recent years regarding the longevity of results following microfracture, with a shift toward cartilage restoration procedures in recent years. This case report describes 2 cases of acute failure following the use of commercially available osteochondral allograft plugs used for the treatment of osteochondral defects of the distal femur. In both cases the chondral surface of the plug delaminated from the underlying cancellous bone, resulting in persistent pain and swelling requiring reoperation and removal of the loose fragments. Caution should be employed when considering use of these plugs for the treatment of osteochondral lesions, as similar outcomes have not been noted with other cartilage restoration techniques.

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“…Cartilage is unable to self-repair after blunt-force trauma, athletic injury, disease or agerelated degeneration. The number of knee surgeries to repair articular cartilage damage each year in the USA increases by 5% annually [38]. The natural lack of vascularization in addition to the minimal cell-tocell contact restricts cartilage to only minimal spontaneous healing because of the slow dissemination of healing factors to distant cells.…”

Section: Ascs In Synthetic Scaffolds For Cartilaginous Regenerationmentioning

confidence: 99%

Strategies for Bioengineered Scaffolds that Support Adipose Stem Cells in Regenerative Therapies

et al. 2016

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Regenerative medicine possesses the potential to ameliorate damage to tissue that results from a vast range of conditions, including traumatic injury, tumor resection and inherited tissue defects. Adult stem cells, while more limited in their potential than pluripotent stem cells, are still capable of differentiating into numerous lineages and provide feasible allogeneic and autologous treatment options for many conditions. Adipose stem cells are one of the most abundant types of stem cell in the adult human. Here, we review recent advances in the development of synthetic scaffolding systems used in concert with adipose stem cells and assess their potential use for clinical applications.

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Trends in the Surgical Treatment of Articular Cartilage Lesions in the United States: An Analysis of a Large Private-Payer Database Over a Period of 8 Years

Cited by 198 publications

References 14 publications

What Is the Effect of Matrices on Cartilage Repair? A Systematic Review

What Is the Effect of Matrices on Cartilage Repair? A Systematic Review

Acute Delamination of Commercially Available Decellularized Osteochondral Allograft Plugs

Strategies for Bioengineered Scaffolds that Support Adipose Stem Cells in Regenerative Therapies

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