Trends in the use of antiepileptic drugs in Taiwan from 2003 to 2007: A Population-Based National Health Insurance study

Hsieh, Liang-Po; Huang, Chin‐Yin

doi:10.1016/j.eplepsyres.2011.05.003

Cited by 47 publications

(50 citation statements)

References 24 publications

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“…Recently, Italiano et al [25] reported that the use of new AEDs for epilepsy remained unchanged in Italy from 2005 to 2011. In contrast, our study demonstrated that new AED use increased markedly from 16.5 % in 2006 to 43.9 % in 2013, reaching a higher level than that in Taiwan [14] (from 14.6 % in 2003 to 25.7 % in 2007) or Australia [13] (from 14.8 % in 2002 to 23.5 % in 2007).…”

Section: Introduction Of New Aeds and Hyperammonemiacontrasting

confidence: 81%

“…According to drug utilization studies performed in the UK at the primary care level from 1993 to 2008, prescription of PHT declined annually whereas use of LTG and LEV increased markedly [11,12]. Significant changes of the prescribing pattern were also observed after the introduction of new AEDs in Australia [13], Taiwan [14], and Europe [15][16][17][18]. However, there has been no investigation into whether changes of AED use affect the incidence of adverse events.…”

Section: Introductionmentioning

confidence: 97%

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Changing incidence of hyperammonemia in Japan from 2006 to 2013: expansion of new antiepileptic drugs reduces the risk of hyperammonemia

Yamamoto

Takahashi

Imai

et al. 2015

Eur J Clin Pharmacol

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Drug interactions caused by enzyme-inducing AEDs, especially phenytoin, are closely related to the development of hyperammonemia. This study demonstrated that introduction of new AEDs changed the co-prescribing pattern in patients receiving valproic acid, resulting in a marked decrease of hyperammonemia. Although their higher cost may be problematic, new AEDs are beneficial for reducing the risk of drug interactions.

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Section: Introduction Of New Aeds and Hyperammonemiacontrasting

confidence: 81%

Section: Introductionmentioning

confidence: 97%

Changing incidence of hyperammonemia in Japan from 2006 to 2013: expansion of new antiepileptic drugs reduces the risk of hyperammonemia

Yamamoto

Takahashi

Imai

et al. 2015

Eur J Clin Pharmacol

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“…Third, we didn’t include all participants in NHIRD for analysis. However, a prior study showed that the distributions of the sampling results were representative of the Taiwanese population [22].…”

Section: Discussionmentioning

confidence: 95%

“…According to the NHIRD, random sampling of the cohort is achieved by using the linear congruential random number generation function of the Sun WorkShop Compiler C 5.0. The distributions of the random samples were representative of the Taiwanese population [22].…”

Section: Methodsmentioning

confidence: 99%

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Initial Medication in Patients of Newly Diagnosed Parkinson’s Disease in Taiwan

et al. 2014

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IntroductionSeveral treatment guidelines for Parkinson’s disease (PD) had been proposed in recent decades. The aim of current study was to investigate the initial medication utilized in newly diagnosed PD subjects in Taiwan during an eleven-year period.MethodsA total of 7,550 patients with newly diagnosed Parkinsonism were retrospectively enrolled from the National Health Insurance Research Database of Taiwan from 2000 to 2010. After excluding patients at risk of secondary or atypical Parkinsonism, those never receiving medication or having incomplete data, 1,645 subjects were included. The participants were then divided into four treating regimen groups, namely levodopa (LD) only group, dopamine agonist (DA) only group, LD+DA group, and No-LD, No-DA group. The demographic data and medication retention rate were compared across the four treatment groups.ResultsLD only and No-LD, No-DA regimens were the main initial choice of PD treatment in Taiwan. LD containing drugs were more often prescribed to the elderly population than the other two treatment regimens, while No-LD, No-DA medication was the major initial choice for younger patients. DA only regimen occupied only 3–4% of the initial PD prescriptions and was given predominantly by neurologists. Over the eleven-year period, there is a trend for the middle-aged population to receive medication containing LD as initial treatment. The one year retention rate of anti-Parkinsonism medication was around 30–50% in our population. Age, polypharmacy, change of one-year daily levodopa equivalent dosage and newly onset of dementia, stroke and psychiatric diseases all affect drug compliance in PD patients.ConclusionsThis is the first long-term study to explore initial pharmacotherapies in an Asian PD population. We hope to provide evidence for adjusting government policies and public education of physicians and PD patients in the future.

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Antiseizure medications for post‐stroke epilepsy: A real‐world prospective cohort study

et al. 2021

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Background and purpose:The management of post-stroke epilepsy (PSE) should ideally include prevention of both seizure and adverse effects; however, an optimal antiseizure medications (ASM) regimen has yet been established. The purpose of this study is to assess seizure recurrence, retention, and tolerability of older-generation and newer-generation ASM for PSE. Methods: This prospective multicenter cohort study (PROgnosis of Post-Stroke Epilepsy [PROPOSE] study) was conducted from November 2014 to September 2019 at eight hospitals. A total of 372 patients admitted and treated with ASM at This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Trends in the use of antiepileptic drugs in Taiwan from 2003 to 2007: A Population-Based National Health Insurance study

Cited by 47 publications

References 24 publications

Changing incidence of hyperammonemia in Japan from 2006 to 2013: expansion of new antiepileptic drugs reduces the risk of hyperammonemia

Changing incidence of hyperammonemia in Japan from 2006 to 2013: expansion of new antiepileptic drugs reduces the risk of hyperammonemia

Initial Medication in Patients of Newly Diagnosed Parkinson’s Disease in Taiwan

Antiseizure medications for post‐stroke epilepsy: A real‐world prospective cohort study

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