Background: In Brazil, primary health care assumes the challenge of organizing and articulating health care networks, based on the performance of multidisciplinary teams linked to basic health units. Given that there are limited studies on the organization of the work process of primary health care teams in Brazilian municipalities that consider the rural-urban typology proposed by the Brazilian Institute of Geography and Statistics, this study aims to analyze the work process of primary health care teams in Brazilian municipalities.Methods: Quantitative evaluation was conducted using secondary data from the third cycle of the National Program for Improving Access and Quality of Primary Care (PMAQ-AB) and the Rural/Urban Classification of the Brazilian Institute of Geography and Statistics. Overall, 37,350 teams that participated in all levels of the PMAQ-AB external evaluation were included. The descriptive analysis considered three axes: 1) territorialization, 2) action planning, and 3) monitoring and self-evaluation. Multiple correspondence analyses were used to verify the relationships between the variables and municipal classifications.Results: Teams from adjacent rural municipalities had the lowest percentage of uncovered population in the territory (21.0%), while those from urban municipalities had the highest percentage with reference population >3,500 people/team (43.0%). It was found that 5,446 (15.1%) teams did not carry out planning, and the highest percentage of teams that executed planning was in the urban strata (85.7%). Monitoring performance was observed in 87.9% of the teams, with approximation of the values among the municipal strata with similar characteristics of location; self-evaluation showed the highest percentage in the adjacent intermediate stratum (90.4%). It was possible to identify three groups of teams with distinct characteristics of territorialization and two groups in relation to planning, monitoring, and self-evaluation.Conclusion: The results suggest important differences in the work process of primary health care teams, which vary according to the characteristics of the municipalities in which they are located.