Trends of Antimicrobial Susceptibility in Clinically Significant Coagulase-Negative Staphylococci Isolated from Cerebrospinal Fluid Cultures in Neurosurgical Adults: a Nine-Year Analysis

Ye, Yi; Tian, Ye; Kong, Yueyue; Ma, Jiawei; Shi, Guangzhi

doi:10.1128/spectrum.01462-21

Cited by 5 publications

(2 citation statements)

References 29 publications

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“…Resistance of CoNS to linezolid increased in the ICU without SDD protocol, where a significant increase of this antibiotic use was also found. CoNS are the main pathogens in health care-associated ventriculitis and meningitis (HCAVM) [ 38 ]. Although linezolid is not registered for the treatment of CoNS infections, it is widely used off-label for the treatment of meningitis, ventriculitis, osteomyelitis and prosthetic-joint infections caused by CoNS promoting emergence of resistance [ 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

Does selective digestive decontamination (SDD) increase antibiotic resistance? Long-term comparison of two intensive care units (with and without SDD) of the same tertiary hospital

Rodríguez-Gascón,

Lloréns-Villar,

Solinís

et al. 2024

Eur J Clin Microbiol Infect Dis

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Purpose The aim of this study was to to compare the antimicrobial resistance rate and its relationship with the antibiotic consumption in two separate Intensive Care Units (ICUs) of the same hospital, one with and other without selective decontamination of the digestive tract (SDD). Methods We performed a retrospective study in the two ICUs of the Araba University Hospital. Trauma and neurosurgical patients are admitted to the SDD-ICU, and general digestive surgery patients go to the no SDD-ICU. From 2014 to 2018 we analyzed the number of isolates, and the bacterial resistance trends of 47 antimicrobial-microorganism combinations. Additionally, antimicrobial consumption was estimated in both ICUs. Resistance rates were also compared with those reported in ENVIN-HELICS Spanish national registry. Results In the ICU with SDD protocol, there was a significant decrease in the resistance of E. coli to amoxicillin/clavulanic acid and in the resistance of E. faecalis to high concentration of gentamycin and high concentration of streptomycin. A significant increase of resistance of Staphylococcus coagulasa negative (CoNS) to linezolid in the no SDD-ICU was also detected. Overall, the level of resistance in the SDD-ICU was lower or of the same order than in the ICU without SDD and that reported in the Spanish national registry. Conclusions SDD had neither a clinically relevant impact on emergence and spread of resistance, nor in the overall systemic antimicrobial use. The patient type rather than the SDD protocol showed to condition the ecology and therefore, the resistance rate in the ICUs.

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Section: Discussionmentioning

confidence: 99%

Does selective digestive decontamination (SDD) increase antibiotic resistance? Long-term comparison of two intensive care units (with and without SDD) of the same tertiary hospital

Rodríguez-Gascón,

Lloréns-Villar,

Solinís

et al. 2024

Eur J Clin Microbiol Infect Dis

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show abstract

“…CoNS consists of a heterogeneous and ever-increasing group of species that colonize the skin and mucosa of their hosts, which could also cause invasive diseases including bloodstream infection, urinary tract infection, and endocarditis 6 . Common CoNS species include Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus capitis, Staphylococcus hominis , etc 7 . The COVID-19 pandemic has significantly changed human lifestyles worldwide.…”

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confidence: 99%

Changes of coagulase-negative Staphylococci infections in children before and after the COVID-19 pandemic in Zhengzhou, China

Li¹,

Ma²,

Guo³

et al. 2023

Journal of Infection

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Coagulase-negative staphylococci are the main causes of bacterial meningitis in duck

Wang,

Meng,

Zhang

et al. 2024

Poultry Science

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Trends of Antimicrobial Susceptibility in Clinically Significant Coagulase-Negative Staphylococci Isolated from Cerebrospinal Fluid Cultures in Neurosurgical Adults: a Nine-Year Analysis

Abstract: Coagulase-negative staphylococci are the main pathogens in health care-associated ventriculitis and meningitis. There are three conclusions from the results of this study.

Cited by 5 publications

References 29 publications

Does selective digestive decontamination (SDD) increase antibiotic resistance? Long-term comparison of two intensive care units (with and without SDD) of the same tertiary hospital

Does selective digestive decontamination (SDD) increase antibiotic resistance? Long-term comparison of two intensive care units (with and without SDD) of the same tertiary hospital

Changes of coagulase-negative Staphylococci infections in children before and after the COVID-19 pandemic in Zhengzhou, China

Coagulase-negative staphylococci are the main causes of bacterial meningitis in duck

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