Trends of skin cancer mortality after transplantation in the United States: 1987 to 2013

Garrett, Giorgia L.; Lowenstein, Stefan E.; Singer, Jonathan P.; He, Steven; Arron, Sarah T.

doi:10.1016/j.jaad.2016.02.1155

Cited by 87 publications

(90 citation statements)

References 24 publications

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“…Recurrence rate is also higher in immunosuppressed patients. In the present study, recurrence was documented in 13% of patients, in line with the 7%‐13% rate reported in previous studies . The median time to recurrence was 2 years.…”

Section: Discussionsupporting

confidence: 92%

“…Although transplantation at the age of 50 years or younger was associated with an aggressive disease, 65% of patients who died of malignancy were older than 50. The association between advanced age and increased mortality from skin cancer has been recently reported in several studies …”

Section: Discussionmentioning

confidence: 79%

“…Skin malignancies in immunosuppressed patients tend to be more aggressive, with higher recurrence rate and increased risk of regional and distant metastases . Skin cancer‐specific mortality rate is nearly nine times higher than that reported for the general population …”

Section: Introductionmentioning

confidence: 97%

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Nonmelanoma skin cancer of the head and neck region in solid organ transplant recipients

et al. 2018

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Background Nonmelanoma skin cancers (NMSC) are the most common malignancies in solid organ recipients. We investigated the incidence, clinical features, and outcome of solid organ recipients with NMSC of the head and neck. Methods A retrospective chart review was conducted for solid organ recipients who were treated from 1992 to 2015 and who developed NMSC of the head and neck. Results Of 3339 organ recipients, 259 patients developed 697 head and neck NMSC. Squamous cell carcinoma was the most common malignancy (55%). The overall 5‐year and 10‐year survival was 68% and 45%. Kidney recipients had better survival outcome than other organ recipients (10 vs 7 years). Advanced‐stage cancers (10%), aggressive patterns of tumors (21%), and treatment with Prograf and Cellcept were associated with increased disease‐specific mortality. Conclusion Solid organ transplant increases the risk of NMSC of the head and neck. Aggressive tumors decrease patient survival and warrant more decisive and multidisciplinary approach.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 79%

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Nonmelanoma skin cancer of the head and neck region in solid organ transplant recipients

et al. 2018

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“…Mortality was highest in patients with MM, which is expected based on prior studies 26 . However, mortality associated with metastatic SCC was 28.3%, similar to previous estimates 27,28 .…”

Section: Discussionsupporting

confidence: 73%

Clinical Findings, Treatments and Outcomes of Transplant Recipients with Metastatic Skin Cancer

2017

ARC Journal of Dermatology

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“…In Norway during 2000–11, 5‐year relative survival rates from localized disease were 82% for men, 88% for women, and 64% and 51%, respectively, for more advanced disease . Organ transplant recipients have a worse prognosis, with SCC mortality rates of 4·94 per 100 000 reported for the U.S. transplant population …”

Section: Incidence Mortality and Geographic Differencesmentioning

confidence: 99%

Cutaneous squamous cell carcinoma: an epidemiological review

2017

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Cutaneous squamous cell carcinoma (SCC) is a common cancer in white populations and its disease burden is often substantially underestimated. SCC occurs more often in men than women and increases dramatically with age; those affected often develop multiple primaries over time, which increases the burden. The main external cause is solar ultraviolet radiation (UVR), with immunosuppression being the other established risk factor, shown by the high SCC rates in organ transplant recipients. Sunbed use and certain genetic disorders and medical conditions are also associated with SCC, while associations with human papillomavirus infection and high bodyweight are not established. The presence of actinic keratoses (AKs) on sun-damaged skin is one of the strongest predictors of SCC in unaffected people and a very small proportion of AKs are SCC precursors, although the true rate of malignant transformation of AKs is unknown. The mainstay of SCC prevention is protection of the skin from undue sun exposure by use of clothing cover and sunscreen during summer or in sunny places. Educational, behavioural and multicomponent interventions directed at individuals ranging from parents of newborns, to school children and adolescents, to outdoor workers, have repeatedly been shown to be effective in improving sun-protective behaviours. Health policies can facilitate SCC prevention by setting standards for relevant behaviours to reduce UVR exposure, for example, by legislated restriction of the tanning industry. Skin cancer prevention initiatives are generally highly cost-effective and public investment should be encouraged to control the growing public health problems caused by SCC.

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Trends of skin cancer mortality after transplantation in the United States: 1987 to 2013

Cited by 87 publications

References 24 publications

Nonmelanoma skin cancer of the head and neck region in solid organ transplant recipients

Nonmelanoma skin cancer of the head and neck region in solid organ transplant recipients

Clinical Findings, Treatments and Outcomes of Transplant Recipients with Metastatic Skin Cancer

Cutaneous squamous cell carcinoma: an epidemiological review

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