Triamcinolone acetonide aqueous nasal spray versus loratadine in seasonal allergic rhinitis: efficacy and quality of life

Condemi, John J.; Schulz, Richard; Lim, Janet

doi:10.1016/s1081-1206(10)62518-5

Cited by 36 publications

(23 citation statements)

References 7 publications

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“…The RQLQ has been used in several trials to assess the effect of intranasal glucocorticosteroids (1085,(1089)(1090)(1091)(1092)(1093)(1094), oral H 1 -antihistamines in seasonal (1095)(1096)(1097), perennial (1077,1078) and PER (1066,1067,1098), the combination of intranasal glucocorticosteroids and oral H 1 -antihistamines (1099), leukotriene receptor antagonists (1100, 1101), allergen immunotherapy in pollinosis (1102)(1103)(1104), omalizumab, an anti-IgE monoclonal antibody (768,1105), allergen avoidance (1106) and homeopathy (1107). Studies have also been performed in children (1108).…”

Section: Evolution Of Qol During Interventionsmentioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,861

1,761

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Section: Evolution Of Qol During Interventionsmentioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,861

1,761

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“…However, review of the literature indicates that intranasal corticosteroids may be as effective as, or even superior to, oral antihistamines in relieving ocular symptoms of AR [9,10,11,12,13]. According to a meta-analysis of randomized, controlled trials published between 1966 and 1997 comparing oral antihistamines and intranasal corticosteroids, only 2 of 11 studies in which ocular symptoms were evaluated found antihistamines to be superior to intranasal corticosteroids [10].…”

Section: Introductionmentioning

confidence: 99%

Intranasal Mometasone Furoate Alleviates the Ocular Symptoms Associated with Seasonal Allergic Rhinitis: Results of a Post Hoc Analysis

Anolik

Nathan

Schenkel³

et al. 2008

Int Arch Allergy Immunol

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Background: Burdensome symptoms of allergic rhinitis (AR) include nasal and ocular symptoms such as itching, tearing and redness. Intranasal corticosteroids are efficacious in the treatment of nasal symptoms of AR. Objective: It was the aim of this study to determine the efficacy of the intranasal corticosteroid mometasone furoate nasal spray (MFNS) in relieving ocular symptoms associated with seasonal AR (SAR). Methods: Ocular symptom data were analyzed for subjects ≧12 years of age, randomized to MFNS 200 µg q.d. (n = 176) or placebo (n = 177) in a placebo-controlled, double-blind clinical trial. Post hoc efficacy analysis assessed the mean change from baseline in subject-reported total ocular symptom scores (TOSS) averaged over the treatment period. Results: Mean baseline TOSS was 4.91 for the MFNS group and comparable (5.05) for the placebo group – combined average for individual symptoms such as itching, tearing and redness ranged from 0 (no symptoms) to 9 (all symptoms, severe). Mean change from baseline in TOSS averaged over days 1–15 was –1.42 for the MFNS group and –0.94 for the placebo group (p = 0.02), for an observed treatment difference of 0.49 (statistical data rounded to 2 decimal positions). Improvement in individual symptoms (eye itching, tearing and redness) contributed to this treatment effect; the greatest improvement occurred with tearing, which decreased –0.52 from the baseline score 1.59 in the MFNS group and –0.31 from 1.67 in those receiving placebo (p < 0.01), for an observed treatment difference of 0.21. Treatment with MFNS was safe and well tolerated. Conclusion: MFNS is effective in reducing ocular symptoms of SAR, in addition to its established efficacy in reducing nasal symptoms of SAR.

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“…Evidence obtained more recently increasingly suggests that INSs may be effective in alleviating ocular symptoms (e.g. eye watering) [18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35]. …”

Section: Introductionmentioning

confidence: 99%

“…The favorable effect of INSs on ocular symptoms [44] was supported by recent studies which included treatment with INSs agents: mometasone furoate (MF) [18,19,20,21], fluticasone furoate (FF) [22,23,24,25,26,27,28], fluticasone propionate (FP) [29,30], budesonide [31], and (to some degree) triamcinolone acetonide (TA) [32] and beclomethasone dipropionate (BDP) aqueous nasal spray [33,34]. However, the effects of INSs on ocular symptoms were inconsistent across some separate studies [37,40].…”

Section: Introductionmentioning

confidence: 99%

Should Intranasal Corticosteroids Be Used for the Treatment of Ocular Symptoms of Allergic Rhinoconjunctivitis? A Review of Their Efficacy and Safety Profile

Lightman

Scadding²

2012

Int Arch Allergy Immunol

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Allergic rhinoconjunctivitis (ARC) presents as nasal symptoms, eye watering and additional signs of ocular allergy (e.g. itchy/burning eyes). Intranasal corticosteroids (INSs) are the most effective treatment for the nasal symptoms of seasonal allergic rhinitis (SAR; based on 4 meta-analyses) and are considered first-line therapy when nasal congestion forms a substantial component of the patient’s rhinitis symptoms. Clinical trial evidence shows that INSs also provide some relief from ocular symptoms of SAR and seasonal ARC in adults. INSs probably alleviate eye watering, the main ocular symptom of SAR, by relieving nasal congestion. Other ocular symptoms also improve with INSs. The mechanism for this effect is unknown, but might relate to naso-ocular reflex reduction. There are limited data on ocular safety with INSs. However, the literature supports the use of INSs over several months as there appears to be no considerable increase in the risk of ocular hypertension or glaucoma.

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Triamcinolone acetonide aqueous nasal spray versus loratadine in seasonal allergic rhinitis: efficacy and quality of life

Cited by 36 publications

References 7 publications

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Intranasal Mometasone Furoate Alleviates the Ocular Symptoms Associated with Seasonal Allergic Rhinitis: Results of a Post Hoc Analysis

Should Intranasal Corticosteroids Be Used for the Treatment of Ocular Symptoms of Allergic Rhinoconjunctivitis? A Review of Their Efficacy and Safety Profile

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