It is generally believed that hospitalized children have insuffıcient hands-on learning experiences. The present authors were able to identify only a few published surveys of hands-on learning in in-hospital classes, and effects of hands-on learning on the children in those classes were not clear. The present study reports a questionnaire survey of the current state of hands-on learning activities in in-hospital classes and effects of those activities on the students. Participants were the teachers of 130 in-hospital classes (62 special classes, 41 elementary school classes, and 27 middle school classes). The results showed that 43.4% of the responding teachers provided nature experiences, such as feeding animals and cultivating plants; 55.8%, social experiences, such as visiting places outside of the hospital or inviting experts and volunteers to the hospital; and 60.5%, activities utilizing resources of the hospital. Fewer activities were provided in the junior high school classes than at the other educational levels. The teachers reported that hands-on learning increased the children's motivation to learn and improved their health. Information and communication technologies (ICT), such as tablet computers, were considered especially useful for children who are vulnerable to infections. The data from the survey suggest that hands-on learning may be effective for children in in-hospital classes. The educational environment should be arranged so that all children can learn actively.