Tribbles role in reproduction

Abstract

Tribbles (TRIB) proteins, a family of evolutionary conserved psuedokinase proteins, modulate various signalling pathways within the cell. The regulatory roles of TRIB make them an important part of a number of biological processes ranging from cell proliferation to metabolism, immunity, inflammation and carcinogenesis. Innate immune system plays a pivotal role during the regulation of reproductive processes that allows successful creation of an offspring. Its involvement initiates from fertilization of the oocyte by spermatozoon and lasts throughout early embryonic development, pregnancy and labour. Therefore, there is a close cooperation between the reproductive system and the innate immune system. Evidence from our lab has demonstrated that improper activation of the innate immune system can reduce embryo implantation, thus leading to infertility. Therefore, control mechanisms regulating the innate immune system function can be critical for successful reproductive events.

The Critical Role of TRIB2 in Cancer and Therapy Resistance

“…During oocyte maturation, TRIB2 expression levels are reduced and TRIB1 and TRIB3 are increased. This may be due to the different role of the TRIBs, which in the case of TRIB2 is more involved in proliferation and therefore is not necessary for oocyte maturation [ 56 ]. On the other hand, in granulosa cells, TRIB2 regulates gene expression, protein degradation and activation of signaling pathways that may contribute to follicular growth, differentiation of steroidogenic cells into luteal cells after ovulation and function of the corpus luteum [ 57 ].…”