“…8,9 The sp 2 carbon materials have been widely studied because of their excellent mechanical, thermal, and electrical properties. 10,11 Among the many different types of carbon materials (e.g., graphite, semiconducting and metallic carbon nanotubes, and single and multilayer graphene), HOPG is often used as the model to understand the basic properties of extended sp 2 carbons in wetting, 12 adsorption, 13 tribology, 14 biosensing, 15 and surface chemistry. 16 Therefore, a fundamental understanding of the interaction between DNA nanostructure and HOPG will pave the way to integrating DNA nanostructure with a broad range of sp 2 carbon materials.…”