Nanoparticle reinforced metals recently emerge as a new class of materials to empower the functionality of metallic materials. There is a remarkable success in self-incorporation of nanoparticles to bulk metals for extraordinary properties. There is also a strong demand to use nanoparticles to enhance the performance of metallic microwires for exciting opportunities in numerous applications. Here, we show for the first time that silver–copper alloy (AgCu) reinforced by tungsten carbide (WC) (AgCu40 (wt %)–WC) was manufactured by a stir casting method utilizing a nanoparticle self-dispersion mechanism. The nanocomposite microwires were successfully fabricated using thermal drawing method. By introducing WC nanoparticles into bulk AgCu40 alloy, the Vickers microhardness was enhanced by 63% with 22 vol % WC nanoparticles, while the electrical conductivity dropped to 20.1% International Annealed Copper Standard (IACS). The microwires of AgCu40–10 vol % WC offered an ultimate tensile strength of 354 MPa, an enhancement of 74% from the pure alloy, and an elongation of 5.2%. The scalable manufacturing method provides a new pathway for the production of metallic nanocomposite micro/nanowires with outstanding performance for widespread applications, e.g., in biomedical, brazing, and electronics industries.