Tribological properties of PVA/PVP blend hydrogels against articular cartilage

Kanca, Yusuf; Milner, Piers; Dini, Daniele; Amis, Andrew A.

doi:10.1016/j.jmbbm.2017.10.027

Cited by 74 publications

(42 citation statements)

References 52 publications

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“…Silicon nitride bioceramics were investigated [317] as well as composite ceramics, to optimize both the hardness and the toughness, such as zirconia toughened alumina [318], carbonfiber reinforced silicone-carbide [319], and hexagonal boron nitride mixed with silicon nitride [320], etc. In addition to the improvement of highly crossed linked UHMWPE, potentially high performance polymers and composites were also investigated, such as ultra-low-wear polyethylene [321], polyetheretherketone (PEEK) [322] and hydrogels [323], porous polycarbonate-urethane and UHMWPE blends [324], polycarbonate urethanes [325], and polyvinyl alcohol and polyvinyl pyrrolidone blend hydrogels [326]. Other composites included hybrid polymer matrix composites reinforced with ceramics [327], Ti6Al4V cellular structures impregnated with PEEK [328]，and ceramic-metal composites [329].…”

Section: Joint Tribologymentioning

confidence: 99%

A review of recent advances in tribology

et al. 2020

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The reach of tribology has expanded in diverse fields and tribology related research activities have seen immense growth during the last decade. This review takes stock of the recent advances in research pertaining to different aspects of tribology within the last 2 to 3 years. Different aspects of tribology that have been reviewed including lubrication, wear and surface engineering, biotribology, high temperature tribology, and computational tribology. This review attempts to highlight recent research and also presents future outlook pertaining to these aspects. It may however be noted that there are limitations of this review. One of the most important of these is that tribology being a highly multidisciplinary field, the research results are widely spread across various disciplines and there can be omissions because of this. Secondly, the topics dealt with in the field of tribology include only some of the salient topics (such as lubrication, wear, surface engineering, biotribology, high temperature tribology, and computational tribology) but there are many more aspects of tribology that have not been covered in this review. Despite these limitations it is hoped that such a review will bring the most recent salient research in focus and will be beneficial for the growing community of tribology researchers.

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Section: Joint Tribologymentioning

confidence: 99%

A review of recent advances in tribology

et al. 2020

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“…Interestingly, one smooth sample in the present study revealed surface damage after sliding indentation against a PCU plug, which seems to resemble surface delamination caused by excess friction as shown by Oungoulian et al (2015) (Oungoulian et al, 2015). The effect of PCU-on-cartilage friction has been thoroughly investigated by Kanca et al (2018), who suggest that excess friction in the PCU samples may be ameliorated by using BCS instead of synovial fluid (Kanca et al, 2018). The type of bathing lubricant may affect the friction, especially during boundary lubrication, which is thought to be the operating lubrication regime at 4 mm/s loading.…”

Section: Discussionmentioning

confidence: 59%

“…Several materials can be used to manufacture these implants, such as metals, polymers, or a combination of both (Salkeld et al, 2016;Nathwani et al, 2017;Martinez-Carranza et al, 2016;Custers et al, 2010;Jeuken et al, 2016;Cook et al, 2014;Kanca et al, 2018). These materials differ considerably in mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

The performance of resurfacing implants for focal cartilage defects depends on the degenerative condition of the opposing cartilage

Damen

Nickien

Ito

et al. 2020

Clinical Biomechanics

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Background: Non-degradable resurfacing implants are being developed for treatment of focal cartilage defects. Performance of these implants has been investigated opposing intact cartilage. This study investigates whether implants would perform equally well when the opposing cartilage is fibrillated. Methods: Human osteochondral strips (~2x1x1 cm) with a smooth (n = 9) or fibrillated (n = 17) cartilage surface were obtained from human tibial plateaus excised during total knee arthroscopy. A custom-made pin-onplate sliding indenter was used to apply simultaneous compression (0.75-3 MPa) and movement (4 mm/s over 6 mm). Either metal implants, polycarbonate-urethane or healthy porcine osteochondral plugs with a diameter of 6 mm were used as indenter. Findings: Cartilage roughness of the osteochondral strips was significantly higher for the fibrillated than the smooth group prior to sliding-indentation. Roughness of the indenters was not significantly altered by sliding indentation using either smooth or fibrillated cartilage. For all but one sample, sliding of smooth cartilage against any of the indenter surfaces did not cause damage. However, samples with fibrillated cartilage showed varied responses from seemingly unaffected to severe tissue wear as quantified by analysis of Indian ink staining and histology. Interpretation: This study demonstrates that the opposing cartilage quality is relevant for the clinical success of implanting an artificial implant in a focal cartilage defect. Therefore it is essential to test the efficacy of newly developed implants against arthritic joint surfaces, and care should be taken when interpreting in vivo studies in which implants are inserted in healthy joints.

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“…Analysing the friction profile of the studied materials, b-TPUe showed to exert less friction towards the native cartilage surface than PLA and PCL, showing µ values closer to the cartilageto-cartilage interaction (55). Also, the mechanical properties of a scaffold are important for engineering tissues, especially for cartilage, which is subjected to cyclic mechanical forces (56).…”

Section: Discussionmentioning

confidence: 95%

Validation of the 1,4‐butanediolthermoplastic polyurethane as a novel material for3Dbioprinting applications

Chocarro‐Wrona

Vicente

Antich

et al. 2020

Bioengineering & Transla Med

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Background Tissue engineering (TE) seeks to fabricate implants that mimic the mechanical strength, structure, and composition of native tissues. Cartilage TE requires the development of functional personalized implants with cartilage-like mechanical properties capable of sustaining high loadbearing environments to integrate into the surrounding tissue of the cartilage defect. Objective In this study we evaluated the novel 1,4-Butanediol thermoplastic polyurethane elastomer (b-TPUe) derivative filament as a 3D bioprinting material with application in cartilage TE. Methods The mechanical behaviour of b-TPUe in terms of friction and elasticity were examined and compared with human articular cartilage, PCL, and PLA. Moreover, infrapatellar fat pad-derived human mesenchymal stem cells (MSCs) were bioprinted together with scaffolds. In vitro cytotoxicity, proliferative potential, cell viability, and chondrogenic differentiation were analysed by Alamar blue assay, SEM, confocal microscopy, and RT-qPCR. Moreover, in vivo biocompatibility and host integration were analysed. Results This article is protected by copyright. All rights reserved. b-TPUe demonstrated a much closer compression and shear behaviour to native cartilage than PCL and PLA, as well as closer tribological properties to cartilage. Moreover, b-TPUe bioprinted scaffolds were able to maintain proper proliferative potential, cell viability, and supported MSCs chondrogenesis. Finally, in vivo studies revealed no toxic effects 21 days after scaffolds implantation, extracellular matrix (ECM) deposition and integration within the surrounding tissue. Conclusions This is the first study that validates the biocompatibility of b-TPUe for 3D bioprinting. Our findings indicate that this biomaterial can be exploited for the automated biofabrication of artificial tissues with tailorable mechanical properties including the great potential for cartilage TE applications.

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Tribological properties of PVA/PVP blend hydrogels against articular cartilage

Cited by 74 publications

References 52 publications

A review of recent advances in tribology

A review of recent advances in tribology

The performance of resurfacing implants for focal cartilage defects depends on the degenerative condition of the opposing cartilage

Validation of the 1,4‐butanediolthermoplastic polyurethane as a novel material for3Dbioprinting applications

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