Tributyltin and the obesogen metabolic syndrome in a salmonid

Meador, James P.; Sommers, Frank C.; Cooper, Kenneth H.; Yanagida, Gladys K.

doi:10.1016/j.envres.2010.11.012

Cited by 65 publications

(28 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is the first study that we know of that has demonstrated increased adiposity surrounding the thyroid follicles of fish following perchlorate exposure, or due to any contaminant. Meador et al (2011) found that Chinook salmon ( Oncorhynchus tshawytscha ) exposed to tributyltin, a well-studied endocrine disruptor, exhibited increased lipid-associated plasma parameters, while some parameters only increased at the low dose treatment. Our observation that lipid droplets increased only in perchlorate-treated subadult stickleback suggests that lipid deposits are mobilized for metabolism in reproductively mature fish, which may explain the absence of this phenotype in adults.…”

Section: Discussionmentioning

confidence: 99%

Exogenous iodide ameliorates perchlorate-induced thyroid phenotypes in threespine stickleback

Gardell

Hippel

Adams

et al. 2017

General and Comparative Endocrinology

View full text Add to dashboard Cite

Perchlorate is a ubiquitous environmental contaminant that has widespread endocrine disrupting effects in vertebrates, including threespine stickleback (Gasterosteus aculeatus). The target of perchlorate is thyroid tissue where it induces changes in the organization, activation, and morphology of thyroid follicles and surrounding tissues. To test the hypothesis that some phenotypes of perchlorate toxicity are not mediated by thyroid hormone, we chronically exposed stickleback beginning at fertilization to perchlorate (10, 30, 100 ppm) or control water with and without supplementation of either iodide or thyroxine (T4). Stickleback were sampled across a one-year timespan to identify potential differences in responses to treatment combinations before and after sexual maturation. We found that most thyroid histomorphological phenotypes induced by perchlorate (follicle proliferation, reduced follicle area (adults only), colloid depletion, thyrocyte hypertrophy (subadults only)) were significantly ameliorated by exogenous iodide supplementation. In contrast, treatment with exogenous T4 did not correct any of the thyroid-specific histopathologies induced by perchlorate. Whole-body thyroid hormone concentrations were not significantly affected by perchlorate exposure; however, supplementation with iodide and T4 significantly increased T4 concentrations. This study also revealed an increased erythrocyte area in the thyroid region of perchlorate-exposed adults, while lipid droplet number increased in perchlorate-exposed subadults. Increased erythrocyte area was ameliorated by both iodide and T4, while neither supplement was able to correct lipid droplet number. Our finding on lipid droplets indicates that exposure to perchlorate in early development may have obesogenic effects.

show abstract

Section: Discussionmentioning

confidence: 99%

Exogenous iodide ameliorates perchlorate-induced thyroid phenotypes in threespine stickleback

Gardell

Hippel

Adams

et al. 2017

General and Comparative Endocrinology

View full text Add to dashboard Cite

show abstract

“…Despite the reported evidences in mammals, little is known on the ability of these chemicals to disrupt lipid metabolism in aquatic organisms, which are often exposed to significant concentrations of these compounds. Interestingly, an increase in whole-body lipid content along with a raise of lipid related plasma parameters (triacylglycerols, cholesterol and lipase) was observed in juvenile chinook salmon (Oncorhynchus tshawytscha) exposed to TBT (Meador et al, 2011). Also, long term exposure to TBT induced lipid and fatty acid accumulation in the ramshorn snail Marisa cornuarietis (Janer et al, 2007).…”

Section: Introductionmentioning

confidence: 98%

Alteration of cellular lipids and lipid metabolism markers in RTL-W1 cells exposed to model endocrine disrupters

et al. 2015

View full text Add to dashboard Cite

“…Nowadays, TBT has been reported as one of the most concerning pollutants in aquatic coastal systems since the levels detected in the environment are in the same order of magnitude of those causing deleterious effects in the biota (Meador et al, 2011). Malformation in oysters (Alzieu, 2000), hormonal imbalance in dolphins (Tanabe, 1999), and imposex in gastropods (Smith, 1981) are among the most reported environmental damages related to the use of TBT-based antifouling paints.…”

Section: Introductionmentioning

confidence: 99%