Tricalcium phosphate doped with Mg2+ and combinations of Mn2+, Zn2+ and Fe3+: A DoE study on sintering, mechanical, microstructural and biological properties

Macedo, D. F.; Cunha, Ana F.; Mano, J. F.; Silva, Abílio P.

doi:10.1016/j.ceramint.2022.04.004

Cited by 7 publications

(6 citation statements)

References 44 publications

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“…These results are in agreement with the literature [1,18,31,45]. There, it was proven that, with the addition of 10 and 20% ZrO 2 , the apparent porosity increased while the bulk density decreased, and this is what happened with the porous biocomposites analyzed in this work.…”

Section: Mechanical Propertiessupporting

confidence: 93%

“…As in previous studies [45], no relevant differences were detected in cell viability proliferation between the pure TCP composition and the TCP compositions doped w combinations of the four metal ions, while the bioceramic composites of TCP with zirco did not show high cell viability. This cell viability can be attributed to the range of m In fact, their cell viability consistently exceeded the 70% threshold, indicating strong biocompatibility.…”

Section: Biological Propertiessupporting

confidence: 72%

“…In this study the most resistant biocomposites have 20% of 3YSZ or 8YSZ. On the other hand, these results can also be explained by the addition of Mg 2+ , that replaces the Ca 2+ ions in its sites (doping effect), which have already been shown to increase the mechanical strength of the biocomposites [45]. Regarding biocomposites manufactured with PMMA, low mechanical strength was already reported by Lee et al [31].…”

Section: Mechanical Propertiesmentioning

confidence: 87%

“…In fact, the growth of the HA phase, which is directly related to the improvement of biocompatibility and osteoinduction, is important in bone reconstruction [1,18,45].…”

Section: Microstructural Propertiesmentioning

confidence: 99%

“…In these conditions, only the approximation of zirconia particles promotes the formation of zirconia agglomerates and partial grain growing with poor densification and superior porosity [52]. Nonetheless, the addition of ions like Mg 2+ promotes the densification of materials [18,45]. Another explanation for the apparent porosity results in the use of the biocomposites manufactured with PMMA (40 wt%).…”

Section: Mechanical Propertiesmentioning

confidence: 99%

See 4 more Smart Citations

TCP Doped with Metal Ions Reinforced with Tetragonal and Cubic Zirconia

Ferro,

Silva,

Macedo

et al. 2023

Biomimetics

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Ceramic biocomposites based on bioactive tricalcium phosphate doped with metal ions are a strategy for obtaining good biomimetics for human bone composition. Manufacturing with PMMA porogen also induces bone-like porosity morphology. The poor strength of tricalcium phosphate can be overcomed by designing ceramic composites reinforced with tetragonal and cubic zirconia. In this work, five different bioceramic composites were manufactured without and with induced porosity and their physical, mechanical, microstructural, and biological properties were studied. With the addition of tetragonal and cubic zirconia, an improvement in strength of 22% and 55%, respectively, was obtained, corresponding to up to 20.7 MPa. PMMA was suitable for adding porosity, up to 30%, with interconnectivity while an excellent hOB cellular viability was achieved for all biocomposites.

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Section: Mechanical Propertiessupporting

confidence: 93%

Section: Biological Propertiessupporting

confidence: 72%

Section: Mechanical Propertiesmentioning

confidence: 87%

“…In fact, the growth of the HA phase, which is directly related to the improvement of biocompatibility and osteoinduction, is important in bone reconstruction [1,18,45].…”

Section: Microstructural Propertiesmentioning

confidence: 99%