Trichinella spiralis: Rapid, immunologically influenced reduction of intestinal, sodium-coupled sugar transport in the rat

Bullick, Graham R.; Frizzell, Raymond A.; Castro, Gilbert A.

doi:10.1016/0014-4894(84)90069-9

Cited by 8 publications

(2 citation statements)

References 11 publications

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“…In vitro studies using isolated intestinal preparations from guinea-pigs, immunized by infection with T. spiralis (Russell & Castro, 1985), or colon from Nippostrongylus-iprimed rats (Baird, Cuthbert & Pearce, 1985), have demonstrated that challenge with soluble, homologous worm antigens leads to net electrogenic ion transport across the mucosa. Similarly, immunologically specific alterations in the transepithelial transport of sodium-hexose occurred in T. spiralissensitized isolated gut segments after challenge (Bullick, Frizzell & Castro, 1983).…”

Section: Immediate Hyper Sensitivity Reactionsmentioning

confidence: 86%

Gastrointestinal mucus, a medium for survival and for elimination of parasitic nematodes and protozoa

Miller

1987

Parasitology

111

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Mucus is a sticky visco-elastic material which coats all mucosal surfaces. Florey, in 1955, noted the following three functions for gastrointestinal mucus: protection of the underlying mucosa from chemical and physical injury, lubrication of the mucosal surface to facilitate passage of luminal contents, and removal of parasites by binding and entrapment. In the 31 years since Florey's review, detailed analyses of the composition of mucus and of the biochemistry of mucin glycoproteins, as well as measurements of the physical properties of mucus from different organs and sites have yielded information at the molecular level which provide additional support for his views on its function (Allen, 1981; Forstner, Wesley & Forstner, 1982).

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Section: Immediate Hyper Sensitivity Reactionsmentioning

confidence: 86%

Gastrointestinal mucus, a medium for survival and for elimination of parasitic nematodes and protozoa

Miller

1987

Parasitology

111

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“…The association between the Trichinella-induced inflammation and absorption has already been reported in other studies (Bullick et al 1984) where the absorption rate for some compounds such as glucose and calcium was significantly depressed during the intestinal phase of trichinellosis.…”

Section: Discussionmentioning

confidence: 68%

The effect of intestinal trichinellosis on oral bioavailability of albendazole in mice

et al. 2009

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The effect of Trichinella spiralis infection on the pharmacokinetic profile of orally administered albendazol has been investigated in mice during the intestinal phase of the disease. Swiss CD-1 mice were orally infected with 300 +/- 50 muscle larvae of T. spiralis and then treated with albendazole (ABZ) formulated in hydroxy-propyl-beta-cyclodextrins at the dose of 10 mg/kg given orally on days 0, 5, 10 and 22 post-infection (p.i.). Blood samples were taken at 0.25, 0.5, 0.75, 1, 5, 6 and 24 h post-treatment (p.t.). Adult worm establishment as well as the histopathological alterations induced in the small intestine was assessed on days 0, 5, 10 and 22 p.i. The area under the blood concentrations to time curve (AUC) for ABZ sulphoxide was not significantly higher in infected mice than in control during the first step of intestinal infection (day 5 p.i.), whereas in the late step (day 10 p.i.), it was significantly lower. On day 22 p.i., the AUC showed similar values in both groups. The histopathological analysis showed a transient acute inflammatory reaction that varied from moderate to severe as the infection progressed from the early to the late intestinal stage. After intestinal infection, the inflammation was mild or absent with no signs of chronic effects. The histopathological studies correlated with the pharmacokinetics of ABZ and show that after transient inflammation induced by intestinal T. spiralis infection, the mucosa is restored to allow absorption of ABZ up to levels comparable to those observed in non-infected controls.

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Immune expulsion of parasitic nematodes from the alimentary tract

Rothwell

1989

International Journal for Parasitology

156

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Trichinella spiralis: Rapid, immunologically influenced reduction of intestinal, sodium-coupled sugar transport in the rat

Cited by 8 publications

References 11 publications

Gastrointestinal mucus, a medium for survival and for elimination of parasitic nematodes and protozoa

Gastrointestinal mucus, a medium for survival and for elimination of parasitic nematodes and protozoa

The effect of intestinal trichinellosis on oral bioavailability of albendazole in mice

Immune expulsion of parasitic nematodes from the alimentary tract

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