Trichloroethylene: Its interaction with hepatic microsomal cytochrome P-450 in vitro

Costa, Anita K.; Katz, Ioni; Ivanetich, Kathryn M.

doi:10.1016/0006-2952(80)90524-9

Cited by 35 publications

(11 citation statements)

References 25 publications

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“…It was commonly used as a metal degreasing agent and a dry cleaning solvent. It is now known that exposure can result in central nervous system depression, hepatotoxicity, and nephrotoxicity (1). TCE persists in the environment for decades, even though it can be metabolized by bacteria through anaerobic, reductive dehalogenation or through cometabolic oxidation (2).…”

mentioning

confidence: 99%

Enhanced metabolism of halogenated hydrocarbons in transgenic plants containing mammalian cytochrome P450 2E1

Doty

Shang

Wilson

et al. 2000

Proc. Natl. Acad. Sci. U.S.A.

248

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mentioning

confidence: 99%

Enhanced metabolism of halogenated hydrocarbons in transgenic plants containing mammalian cytochrome P450 2E1

Doty

Shang

Wilson

et al. 2000

Proc. Natl. Acad. Sci. U.S.A.

248

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“…Cytochrome P450 2E1 is a mammalian liver enzyme known to metabolize a wide range of xenobiotic compounds; among these is TCE, a major environmental pollutant (Costa et al 1980 ;Guengerich et al 1991 ) . A. rhizogenes strain A4 harbouring a binary vector with rabbit P450 2E1 was used to transform A. belladona.…”

Section: Role Of Hairy Roots In Phytoremediationmentioning

confidence: 99%

Hairy Roots: A Promising Tool for Phytoremediation

Majumder

Jha

2011

Microorganisms in Environmental Management

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Environmental pollution caused by natural processes or anthropogenic activities is a major global problem. Although several physical and chemical strategies have been used for environmental remediation, these methods are expensive and associated with certain limitations. Phytoremediation is an alternative, biological approach where different plant species are used for the removal of pollutants from the environment or for converting toxic molecules to non toxic forms. Both organic and inorganic compounds of various types are the targets of phytoremediation. The technique is cheaper than other established methods and has several advantages like soil stabilization, production of biofuels, non invasiveness etc. Plants readily absorb certain compounds, otherwise considered contaminants, through the root system and utilize for their normal growth and development. Hairy roots of plants are among the several experimental systems which have been employed to improve the effi ciency of phytoremediation. Hairy root disease, characterized by a massive production of adventitious roots with numerous root hairs at the wound site, is caused by Agrobacterium rhizogenes , a gram negative soil bacterium. The bacterium transfers a segment (the transferred DNA or T-DNA) of its root inducing (Ri) megaplasmid into the plant genome, modifying the normal hormonal metabolism of the plant; this hormonal imbalance induces the formation of hairy roots at the site of infection. Apart from being suitable for the production of a wide array of valuable secondary metabolites, hairy roots possess tremendous potential for phytoremediation. Hairy roots of different plant species have been investigated for the accumulation and biodegradation of hazardous compounds. The present review summarizes the role of plant hairy roots in phytoremediation research.

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“…In the 1970s, it was already accepted that trichloroethylene is oxidized by the hepatic cytochrome P450 to form reactive intermediate(s), which irreversibly bind(s) to proteins and DNA, and affect cytochrome P450 activity through accelerated degradation (28)(29)(30)(31)(32)(33)(34). Since hepatic cytochrome P450 is generally considered to be one of the indicators of the free (or regulatory) heme pool (35), the decline in cytochrome P450 under trichloroethylene intoxication might affect some cell functions through the regulatory heme.…”

Section: Once Upon a Timementioning

confidence: 99%

“…It is suggested that the decrease in cytorchrome P450 is due not only to δ-aminolevulinate dehydratase inhibition but also to the accelerated degradation of cytochrome P450 by trichloroethylene (33,34).…”

Section: Once Upon a Timementioning

confidence: 99%

Regulatory heme and trichloroethylene intoxication: A possible explanation of the case of “A Civil Action”

Fujita

Nishitani

Ogawa

2002

Environ Health Prev Med

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In 1998, a movie entitled "A Civil Action" was released. The movie described the Woburn case, begun in 1982 and concluded in 1990, one of the most famous cases of trichloroethylene pollution. In a small town near Boston, twelve children died of leukemia, which seemed attributable to trichloroethylene contamination of the drinking water. The victims, however, could not win the case, since evidence that the identified chemicals could cause leukemia and other human illnesses was rather sketchy. There have been many cases of trichloroethylene pollution in industrial nations including Japan, therefore, we reconsidered the missing link. Our conclusion is that the disease occurred not by a direct effect of the chemical hazard on biological macromolecules but by an indirect effect through the physiological system such as signal transduction and transcriptional regulation. In 1984, we reported a marked reduction in the regulatory heme pool by trichloroethylene exposure, however, the biological significance was not well understood. Recently, we found that the DNA binding activity of Bach1, a negative regulator of genes, is controlled by heme, the regulation of which seems to explain how leukemia develops. The heterodimer of Bach1 with MafK recognizes Maf recognition elements (MAREs) competing with the erythroid type positive regulator, a complex of NF-E2 with MafK. Bach1/MafK occupies MAREs under lower heme conditions, whereas MAREs are open to NF-E2/ MafK along with increasing heme concentration. Since the NF-E2/MafK function is closely related to normal erythroid differentiation, of which disorders such as sideroblastic anemia are often related to neoplasia; i.e., a clonal disorder that can progress to leukemia. Thus, a marked decline in regulatory heme by trichloroethylene intoxication could be one of the pathways to leukemia.

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Trichloroethylene: Its interaction with hepatic microsomal cytochrome P-450 in vitro

Cited by 35 publications

References 25 publications

Enhanced metabolism of halogenated hydrocarbons in transgenic plants containing mammalian cytochrome P450 2E1

Enhanced metabolism of halogenated hydrocarbons in transgenic plants containing mammalian cytochrome P450 2E1

Hairy Roots: A Promising Tool for Phytoremediation

Regulatory heme and trichloroethylene intoxication: A possible explanation of the case of “A Civil Action”

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