Trichophyton Asthma: Sensitisation of Bronchi and Upper Airways to Dermatophyte Antigen

Ward, GeorgeW; Rose, Gail; Karlsson, Göran; Platts-Mills, T.A.E.

doi:10.1016/s0140-6736(89)92863-8

Cited by 104 publications

(86 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This raises the question of whether the proposed Schizophyllum asthma is actually a new clinical entity similar to both Trichophyton asthma [15,16] and Candida asthma [17], or instead is a precursor of ABPM caused by S. commune.…”

Section: Introductionmentioning

confidence: 99%

Two cases of Schizophyllum asthma: Is this a new clinical entity or a precursor of ABPM?

Ogawa

Fujimura

Takeuchi

et al. 2011

Pulmonary Pharmacology & Therapeutics

View full text Add to dashboard Cite

Abstract(Background) There is a close link between fungal sensitization and asthma severity.Though Schizophillum commune (S. commune, called"suehirotake"in Japanese), one of the basidiomycetous (BM) fungi, is a fungus that can cause allergic bronchopulmonary mycosis (ABPM) and allergic fungal sinusitis (AFS), whether the fungus causes or sensitizes the asthma is unclear. (Methods) The bronchial provocation test using S. commune may be a causative fungal antigen of bronchial asthma.

show abstract

Section: Introductionmentioning

confidence: 99%

Two cases of Schizophyllum asthma: Is this a new clinical entity or a precursor of ABPM?

Ogawa

Fujimura

Takeuchi

et al. 2011

Pulmonary Pharmacology & Therapeutics

View full text Add to dashboard Cite

show abstract

“…The factors that influence the risk of asthma have been divided into those that cause the development of asthma and those that trigger asthma symptoms. It is known that fungi involved in outdoor allergens are important as environmental factors, and our recent studies suggested that S. commune is an important candidate organism acting as a causative fungal antigen of bronchial asthma [9] similar to Trichophyton species [17][18][19][20].…”

Section: Discussionmentioning

confidence: 99%

The Influence of Schizophyllum commune on Asthma Severity

Ogawa

Fujimura

Takeuchi

et al. 2011

Lung

View full text Add to dashboard Cite

The sensitization and exposure to fungal allergens have been reported to be associated with asthma. The aim of this study was to clarify the impact of sensitization to Schizophyllum commune (S. commune) on the severity and exacerbations of asthma.Ninety-two patients with asthma of various levels of severity (mild (n=18), moderate (28), and severe (46)) and exacerbation severity (moderate (n=43) and severe (6)), were retrospectively examined with regard to fungal sensitization such as specific IgE or intradermal skin reactions against S. commune and other common allergens. We also classified the patients into 3 groups; 1) 3 or more asthma attacks during the past 1 year (F-BA) (n=29), 2) one or two asthma attacks (NF-BA) (n=20), and 3) no asthma attack (C-BA) (n=43).The positive rate of late cutaneous reactions to S. commune was higher in patients with severe asthma (41.2%) than moderate (26.1%) and mild asthma (6.7%), and was significantly different among the three groups (p<0.05). Though the ratio did not show significant difference between the patients having a severe (83.3%) and moderate (36.1%) exacerbation, it was higher in F-BA (60.9 %) than in NF-BA (21.1%) and C-BA patients (10.0%), and it was significantly different among the three groups (p=0.0002). A multivariate analysis identified positive results for late phase skin 4 reactions to S. commune and the age of the patients as an independent determinant of asthma severity, and the skin results and %FVC an independent determinant of exacerbation frequency.This study demonstrated that S. commune is an environmental fungus that appears to enhance both the severity of asthma and the exacerbation frequency.

show abstract

“…Patients demonstrated both upper and lower airway sensitization to dermatophyte antigens after bronchial and nasal challenge. 18 The diagnosis and treatment of asthma are well described in the National Asthma Education Program's expert panel report. 7 …”

Section: Asthmamentioning

confidence: 99%

Spectrum of Noninfectious Health Effects From Molds

Mazur¹,

Kim²

2006

Pediatrics

View full text Add to dashboard Cite

Molds are multicellular fungi that are ubiquitous in outdoor and indoor environments. For humans, they are both beneficial (for the production of antimicrobial agents, chemotherapeutic agents, and vitamins) and detrimental. Exposure to mold can occur through inhalation, ingestion, and touching moldy surfaces. Adverse health effects may occur through allergic, infectious, irritant, or toxic processes. The cause-and-effect relationship between mold exposure and allergic and infectious illnesses is well known. Exposures to toxins via the gastrointestinal tract also are well described. However, the cause-and-effect relationship between inhalational exposure to mold toxins and other untoward health effects (eg, acute idiopathic pulmonary hemorrhage in infants and other illnesses and health complaints) is controversial and requires additional investigation. In this report we examine evidence of fungal-related illnesses and the unique aspects of mold exposure to children. Mold-remediation procedures are also discussed. BACKGROUND

show abstract

Trichophyton Asthma: Sensitisation of Bronchi and Upper Airways to Dermatophyte Antigen

Cited by 104 publications

References 16 publications

Two cases of Schizophyllum asthma: Is this a new clinical entity or a precursor of ABPM?

Two cases of Schizophyllum asthma: Is this a new clinical entity or a precursor of ABPM?

The Influence of Schizophyllum commune on Asthma Severity

Spectrum of Noninfectious Health Effects From Molds

Contact Info

Product

Resources

About