Trichosporon asahii causing nosocomial urinary tract infections in intensive care unit patients: genotypes, virulence factors and antifungal susceptibility testing

Abstract

Trichosporon asahii is the causative agent of both superficial and deep-seated infections of increasing morbidity and mortality. Urinary tract infections (UTIs) due to T. asahii, frequently associated with indwelling medical devices, have been reported over the years. However, few studies have specifically focused on the genotypic diversity of T. asahii isolates from urine specimens from intensive care units (ICUs), let alone potential virulence factors and antifungal susceptibility testing. In the present study, 23 T. asahii isolates were collected from UTI patients in ICUs

Trichosporon inkin biofilms produce extracellular proteases and exhibit resistance to antifungals

“…Biofilms produced by Trichosporon spp. also presented higher tolerance to antifungals (Di Bonaventura et al, 2006;Iturrieta-González et al, 2014;Liao et al, 2014;Sun et al, 2012). Data from the present study reveal that planktonic cells showed susceptibility to azoles and resistance to amphotericin B and caspofungin.…”

“…Liao et al (2015) tested ethanol efficacy against T. asahii biofilms in three different adhesion times, at 30 min, 1 and 2 h, with a starter inoculum of 10 6 cells ml 21 in RPMI medium. Sun et al (2012) evaluated the same adhesion times, at 30 min, 1 and 2 h, in T. asahii biofilms, with a starter inoculum of 10 5 cells ml…”

“…Despite the importance of this subject, there are few reports on Trichosporon spp. biofilms (Di Bonaventura et al, 2006;Dostálková et al, 2015;Iturrieta-González et al, 2014;Junqueira et al, 2012, Lakshmi & Das, 2013Liao et al, 2014Liao et al, , 2015Sun et al, 2012).…”

Trichosporonosis – An Association With Clinical Factors and Its Outcome

“…In another study by Wei sun, et al, though diabetes was the most common risk factor the percentage reported was little less i.e. 34.7% [28]. This difference may be due to the variations in the prevalence of diabetes mellitus in different geographical regions.…”

Mycoses and Antifungals: reviewing the basis of a current problem that still is a biotechnological target for marine products

“…In the recent years other fungi emerged as important infections agents, including yeast species such as non-albicans Candida species, Cryptococcus sp., Trichosporon spp., and Rhodotorula spp. and filamentous fungi such as Fusarium spp., Rhizopus spp., Rhizomucor spp., and phaeohyphomycosis agents (Sun et al, 2012;Juyal et al, 2013;Kim et al, 2013;Muhammed et al, 2013;Jaın et al, 2014;Schieffelin et al, 2014).…”