Trichosporon mycotoxinivorans Infection in Patients with Cystic Fibrosis

Shah, Avani V.; McColley, Susanna A.; Weil, Diane; Zheng, Xiaotian

doi:10.1128/jcm.03309-13

Cited by 23 publications

(10 citation statements)

References 10 publications

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“…with severe exacerbations in CF patients [5]. On the other hand, the results of the most recent study by Shah et al showed that the isolation of T. mycotoxinivorans from CF patients is not necessarily associated with significant changes in clinical status [6]. Here we report on a CF patient with repeated isolation of T. mycotoxinivorans in respiratory specimens during the past 9 years.…”

Section: Introductionmentioning

confidence: 74%

A case report of a cystic fibrosis patient with repeated isolation of Trichosporon mycotoxinivorans identified by a novel short-extraction method

et al. 2016

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Background Trichosporon mycotoxinivorans is a recently described yeast-like fungal organism and its association as a pathogen for patients with cystic fibrosis (CF) was reported previously. We show the clinical course of a CF patient over 9 years as well as the applications of modern molecular and proteomic identification techniques of this rare fungus.Case presentationWe present the case of a 32-year-old male CF patient with sputum cultures continuously positive with the anamorphic yeast T. mycotoxinivorans during 9 years. Furthermore, susceptibility testing of T. mycotoxinivorans to different antifungals were performed. In addition, a rapid identification method of this novel fungal pathogen with matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) was applied using a simple extraction protocol.ConclusionsOur case presentation confirms T. mycotoxinivorans as a potential emerging pathogen in patients with CF. However, our CF patient showed mild symptoms over a very long time period of 9 years. A short MALDI-TOF MS procedure allows reliable and rapid identification of T. mycotoxinivorans and therefore should facilitate further study on the clinical relevance and epidemiology of this unusual fungal organism.

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Section: Introductionmentioning

confidence: 74%

A case report of a cystic fibrosis patient with repeated isolation of Trichosporon mycotoxinivorans identified by a novel short-extraction method

et al. 2016

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“…Moreover, this microorganism has been related to deep-seated infections in immunocompromised patients with invasive disposals in India (17). The use of Bruker's MALDI-TOF MS as a reliable tool for A. mycotoxinivorans species identification has helped strengthen the epidemiologic link of T. mycotoxinivorans to cystic fibrosis (18,19). Thus, it appears that inclusion of the species in the database used for clinical diagnosis is now mandatory.…”

Section: Discussionmentioning

confidence: 99%

Evaluating and Improving Vitek MS for Identification of Clinically Relevant Species of Trichosporon and the Closely Related Genera Cutaneotrichosporon and Apiotrichum

et al. 2017

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Trichosporon species are relevant etiologic agents of hospital-acquired infections. High mortality rates are attributed to Trichosporon deep-seated infections in immunocompromised individuals, making fast and accurate species identification relevant for hastening the discovery of best-targeted therapy. Recently, Trichosporon taxonomy has been reassessed, and three genera have been proposed for the pathogenic species: Trichosporon, Cutaneotrichosporon, and Apiotrichum. Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has replaced old phenotypic methods for microorganism identification in clinical laboratories, but spectral profile databases have to be evaluated and improved for optimal species identification performance. Vitek MS (bioMérieux) is one of the commercially available MALDI-TOF MS platforms for pathogen identification, and its spectral profile databases remain poorly evaluated for Trichosporon, Cutaneotrichosporon, and Apiotrichum species identification. We herein evaluated and improved Vitek MS for the identification of the main clinical relevant species of Trichosporon, Cutaneotrichosporon, and Apiotrichum using a large set of strains and isolates belonging to different yeast collections in Brazil and France.KEYWORDS Trichosporon, Cutaneotrichosporon, Apiotrichum, Vitek M, MALDI-TOF mass spectrometry O pportunistic non-Candida yeasts, including Trichosporon spp., are emerging pathogens of deep-seated infections in the context of immunodepression and/or invasive procedures (1, 2). In addition, outbreaks of catheter-related fungemia by these pathogens have been described in neonatal intensive care units (3).Based on molecular phylogenetic analysis, Trichosporon pathogenic species were initially subdivided into three clades: clade Porosum, which included the species

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“…Trichosporon mycotoxinivorans has been described as a chronic colonizer of the CF airways, but also as a highly pathogenic yeast in a couple of cases [27][28][29][30]. Until now, it is not clearly understood which factors trigger the variable effects of this yeast species on the CF lung.…”

Section: Epidemiology Of Fungal Colonization Of the Airways In Cf Patmentioning

confidence: 99%

Organization of Patient Management and Fungal Epidemiology in Cystic Fibrosis

et al. 2017

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The achievement of a better life for cystic fibrosis (CF) patients is mainly caused by a better management and infection control over the last three decades. Herein, we want to summarize the cornerstones for an effective management of CF patients and to give an overview of the knowledge about the fungal epidemiology in this clinical context in Europe. Data from a retrospective analysis encompassing 66,616 samples from 3235 CF patients followed-up in 9 CF centers from different European countries are shown.

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Trichosporon mycotoxinivorans Infection in Patients with Cystic Fibrosis

Cited by 23 publications

References 10 publications

A case report of a cystic fibrosis patient with repeated isolation of Trichosporon mycotoxinivorans identified by a novel short-extraction method

A case report of a cystic fibrosis patient with repeated isolation of Trichosporon mycotoxinivorans identified by a novel short-extraction method

Evaluating and Improving Vitek MS for Identification of Clinically Relevant Species of Trichosporon and the Closely Related Genera Cutaneotrichosporon and Apiotrichum

Organization of Patient Management and Fungal Epidemiology in Cystic Fibrosis

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