Trichosporon species infection in bone marrow transplanted patients

Moretti-Branchini, Maria Luiza; Fukushima, Kazutaka; Schreiber, A. Z.; Nishimura, Kazuko; Papaiordanou, Priscila M. O.; Trabasso, Plı́nio; Tanaka, Reiko; Miyaji, Makoto

doi:10.1016/s0732-8893(01)00215-2

Cited by 65 publications

(45 citation statements)

References 14 publications

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“…3,4 On the other hand, infections by resistant microorganisms are increasing, resulting in higher mortality rates, increased hospitalization periods, and consequent higher cost to hospital services. 21 In the present study, yeasts of the Trichosporon genus, considered as emergent agents of hospital infections, 15 were also isolated at substantial levels, both from the healthcare staff and from all environmental surfaces investigated.…”

Section: Discussionmentioning

confidence: 68%

Monitoramento de fungos anemófilos e de leveduras em unidade hospitalar

et al. 2005

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ObjectiveTo monitor and characterize airborne filamentous fungi and yeasts from abiotic and biotic sources within a hospital unit. Methods Collections were carried out on a monthly basis, at two different time periods, from the adult and pediatric intensive care units and surgical center of a hospital in Araraquara, Southeastern Brazil. Collection of airborne fungi was carried out using a simple-stage Andersen sample. The presence of yeasts was investigated in samples taken from the hands and oropharynx of staff members as well as from the surface of beds and doorknobs inside the critical areas. Results Thirty-two genera of airborne fungi and were recovered from the surgical center and 31 from the intensive care units. Genera most frequently isolated were Cladophialophora spp., Fusarium spp., Penicillium spp., Chrysosporium spp. and Aspergillus spp. During the study period, a new unit was built in the hospital, which coincided with an increase in Cladophialophora spp., Aspergillus spp., and Fusarium spp. colony counts. Yeasts were found in 39.4% of samples obtained from healthcare staff (16.7% from interdigital spaces, 12.1% from nailbeds, and 10.6% from oropharynx) and in 44% of furniture samples, with a predominance of the Candida genus (C. albicans, C. guilliermondii, C. parapsilosis e C. lusitaniae), followed by Trichosporon spp. ConclusionsWe found a relatively high number of airborne fungi (potentially pathological) in special areas and expressive levels of yeasts in both biotic and abiotic samples. Microbiological and environmental monitoring should be conducted, especially in special areas which include immunocompromised patients, who are more susceptible to the exposure to environmental and staff-derived pathogens.

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Section: Discussionmentioning

confidence: 68%

Monitoramento de fungos anemófilos e de leveduras em unidade hospitalar

et al. 2005

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“…Trichosporon infections are rare but have been associated with a wide spectrum of clinical manifestations, ranging from superficial involvement in immunocompetent individuals such as white piedra (40,47) to severe systemic disease in immunocompromised patients with a pattern similar to candidiasis (6,19,29,30,43,58). Rodrigues et al (43) described twenty-two cases of nosocomial infection caused by T. asahii, detected during a period of six years (1999)(2000)(2001)(2002)(2003)(2004)(2005) in a Brazil hospital.…”

Section: Introductionmentioning

confidence: 99%

“…Unfortunately, difficulties in the identification of these microorganisms lead to delays in treatment and post-mortem diagnosis (30,31).…”

Section: Introductionmentioning

confidence: 99%

“…In Brazil there are few survey on these yeasts (30,34,43). In this study we examined the genetic diversity and biochemical characteristics of T.asahii strains recovered from clinical specimens (oral cavity and urine) from patients in Intensive Care Units (ICU), as well as the correlation between the drug susceptibility profile and genetic changes detected by RAPD (primer M13 and 6).…”

Section: Introductionmentioning

confidence: 99%

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Genetic diversity and antifungal susceptibility testing of Trichosporon asahii isolated of Intensive Care Units patients

Silva¹,

Fusco‐Almeida²,

Matsumoto³

et al. 2008

Braz. J. Microbiol.

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Trichosporon asahii is an opportunistic pathogen, associated with a high mortality rate in immunocompromised patients. In this study, ten isolates, recovered from oral cavity and urine of patients in Intensive Care Units (ICU) over six months, were identified by classical and molecular methods, typed by RAPD and tested in vitro for susceptibility to fluconazole, itraconazole, 5-flucytosine and amphotericin B. A total agreement between the identification of Trichosporon sp by PCR based on sequences of the Internal Transcribed Spacer Regions (ITS) and on the sequences of small-subunit (SSU) ribosomal DNA (rDNA) was found. Randomly amplified of polymorphic DNA (RAPD), with primers P6 and M13, was used to determine the genomic profiles. The dendogram analysis indicated that almost all strains showed similarity >0.9 among them and all strains were multidrug-resistant. This study brings new results on the identification and genotyping of T. asahii isolated from Brazilian ICU patients and information about their antifungal drugs susceptibility.

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“…have been implicated as a cause of disseminated infections, including endophthalmitis, bloodstream infections, prosthetic valve endocarditis (19), brain abscess, hepatitis (25), and peritonitis (2,3,5,6,9,(12)(13)(14)(23)(24)(25), especially in immunosuppressed patients (6,15). T. inkin specifically has caused endocarditis (18), vascular access infection (11), pneumonia (20), lung abscess (1), and peritonitis associated with peritoneal dialysis (9,13).…”

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confidence: 99%