Trichothecene Chemotypes of Three Fusarium Species

Miller, J. David; Greenhalgh, R.; Wang, Yu‐Zhong; Lu, Ming

doi:10.2307/3759927

Cited by 181 publications

(154 citation statements)

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“…When assessing the risk or when designing toxicity studies, one should take into account the fact that there is a high likelihood of having several toxins in the same sample. Miller et al (1991) affirmed that DON is produced from 3-ADON by chemotypes IA in Europe and Asia (warmer regions) and from 15-ADON, by chemotypes IB, in USA and South America (cooler regions) (Miller, Grennhalgh, Wang and Lu, 1991). However, in our study, DON has been found together with their precursors, 3-ADON and 15-ADON.…”

Section: Resultscontrasting

confidence: 54%

Co-occurrence of type-A and type-B trichothecenes in barley from a northern region of Spain

et al. 2012

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Section: Resultscontrasting

confidence: 54%

Co-occurrence of type-A and type-B trichothecenes in barley from a northern region of Spain

et al. 2012

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“…Three strain-specific profiles of trichothecene metabolites (chemotypes) have been identified within the B-trichothecene lineage of Fusarium: (i) nivalenol and acetylated derivatives (NIV chemotype), (ii) deoxynivalenol and 3-acetyldeoxynivalenol (3ADON chemotype), and (iii) deoxynivalenol and 15-acetyldeoxynivalenol (15ADON chemotype) (8). Only a hydroxyl group at C-4 in nivalenol distinguishes it from deoxynivalenol.…”

mentioning

confidence: 99%

Ancestral polymorphism and adaptive evolution in the trichothecene mycotoxin gene cluster of phytopathogenic Fusarium

Ward

Bielawski

Kistler

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

483

419

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Filamentous fungi within the Fusarium graminearum species complex (Fg complex) are the primary etiological agents of Fusarium head blight (scab) of wheat and barley. Scab is an economically devastating plant disease that greatly limits grain yield and quality. In addition, scabby grain is often contaminated with trichothecene mycotoxins that act as virulence factors on some hosts, and pose a serious threat to animal health and food safety. Strain-specific differences in trichothecene metabolite profiles (chemotypes) are not well correlated with the Fg complex phylogeny based on genealogical concordance at six single-copy nuclear genes. To examine the basis for this discord between species and toxin evolution, a 19-kb region of the trichothecene gene cluster was sequenced in 39 strains chosen to represent the global genetic diversity of species in the Fg complex and four related species of Fusarium. Phylogenetic analyses demonstrated that polymorphism within these virulence-associated genes is transspecific and appears to have been maintained by balancing selection acting on chemotype differences that originated in the ancestor of this important group of plant pathogens. Chemotype-specific differences in selective constraint and evidence of adaptive evolution within trichothecene genes are also reported.

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“…Species within the FGSC produce type B trichothecenes such as deoxynivalenol (DON) and nivalenol (Aoki et al 2012). The DON-producing species accumulate primarily 3-acetyldeoxynivalenol (3-ADON) or 15-acetyldeoxynivalenol (15-ADON) in addition to DON (Miller et al 1991). Variation in trichothecene chemotypes may have important implications for toxicity (Forsell and Pestka 1985;Luongo et al 2008;Minervini et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Genetic and phenotypic diversity within the Fusarium graminearum species complex in Norway

et al. 2015

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As has been observed in several European countries, the frequency of Fusarium head blight (FHB) caused by members of the Fusarium graminearum species complex (FGSC) has increased in Norwegian cereals in recent years, resulting in elevated levels of deoxynivalenol in cereal grains. The objective of this study was to determine if this increase was associated with changes in FGSC composition within Norway. FGSC isolates collected from wheat, oats and barley in Norway during two periods, mainly 1993-1998 and 2004-2007, were characterized to determine species and trichothecene genotype composition and to assess levels of genetic variation and population structure. In vitro growth rates at different temperatures and aggressiveness in spring wheat were further characterized for a sub-selection of isolates. All Norwegian isolates were identified as F. graminearum. The 3-acetyl-deoxynivalenol (3-ADON) trichothecene type was dominant. However, isolates with the 15-ADON chemotype were detected in Norway for the first time and may represent a recent introduction of this trichothecene type. Bayesian-model based clustering and analyses of genetic differentiation indicated the persistence over the last 20 years of two sympatric and partially admixed populations of F. graminearum in Norway. Significant differences in average in vitro growth rates and aggressiveness were observed between these two populations. Our results demonstrate that the recent increase in prevalence of the FGSC in Norwegian cereals do not correspond to any dramatic changes in FGSC species or trichothecene chemotype composition. However, significant changes in population frequencies were observed among Norwegian F. graminearum.

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Trichothecene Chemotypes of Three Fusarium Species

Cited by 181 publications

References 0 publications

Co-occurrence of type-A and type-B trichothecenes in barley from a northern region of Spain

Co-occurrence of type-A and type-B trichothecenes in barley from a northern region of Spain

Ancestral polymorphism and adaptive evolution in the trichothecene mycotoxin gene cluster of phytopathogenic Fusarium

Genetic and phenotypic diversity within the Fusarium graminearum species complex in Norway

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