Triclosan inhibits the activation of human periodontal ligament fibroblasts induced by lipopolysaccharide from &lt;i&gt;Porphyromonas gingivalis&lt;/i&gt;

Shu, Wei; Zhang, Yanman; Zhang, Chen; Qin, You; Zhou, Hong; Wen, Shuang

doi:10.7555/jbr.34.20200026

Cited by 8 publications

(4 citation statements)

References 24 publications

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“…After treatment, the CCK-8 solution was added into each well to incubate for 30 min. Absorbance was obtained by DigiScan Microplate Reader at a wavelength of 450 nm [ 21 ] .…”

Section: Methodsmentioning

confidence: 99%

Histone lactylation promotes cell proliferation, migration and invasion through targeting HMGB1 in endometriosis

Chen¹,

Qin²,

Sun³

et al. 2023

J Biomed Res

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Endometriosis is defined as a condition with endometrium-like tissues migrating outside of the pelvic cavity. However, the mechanism of endometriosis is still unclear. Lactate can be covalently modified to lysine residues of histones and other proteins, which is called lactylation. The results showed that the higher level of lactate and lactate dehydrogenase A enhanced the histone H3 lysine 18 lactylation (H3K18lac) in ectopic endometrial tissues and ectopic endometrial stromal cells than that in normal endometrial tissues and normal endometrial stromal cells. Lactate promoted cell proliferation, migration, and invasion in endometriosis. Mechanistically, lactate induced H3K18lac to promote the expression of high-mobility group box 1 (HMGB1) in endometriosis, and HMGB1 knockdown significantly reduced the cell proliferation, migration, and invasion of the lactate-treated cells through the phosphorylation of AKT. In conclusion, lactate could induce histone lactylation to promote endometriosis progression by upregulating the expression of HMGB1, which may provide a novel target for the prevention and treatment of endometriosis.

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“…After treatment, the CCK-8 solution was added into each well to incubate for 30 min. Absorbance was obtained by DigiScan Microplate Reader at a wavelength of 450 nm [ 21 ] .…”

Section: Methodsmentioning

confidence: 99%

Histone lactylation promotes cell proliferation, migration and invasion through targeting HMGB1 in endometriosis

Chen¹,

Qin²,

Sun³

et al. 2023

J Biomed Res

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“…Many investigators have reported that Pg -LPS induces the production of pro-inflammatory cytokines, i.e., IL-1, IL-6, IL-8, and tumor necrosis factor alpha (TNF-α), via the NF-κB pathway in HGFs [ 25 , 26 , 27 ]. HPLFs also perform a similar function to that of HGFs [ 28 , 29 ]. Furthermore, HPLFs share some of the properties of both osteoblasts and cementoblasts [ 30 ].…”

Section: Chronic Periodontitismentioning

confidence: 99%

Biological Roles of Fibroblasts in Periodontal Diseases

Naruishi

2022

Cells

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Periodontal diseases include periodontitis and gingival overgrowth. Periodontitis is a bacterial infectious disease, and its pathological cascade is regulated by many inflammatory cytokines secreted by immune or tissue cells, such as interleukin-6. In contrast, gingival overgrowth develops as a side effect of specific drugs, such as immunosuppressants, anticonvulsants, and calcium channel blockers. Human gingival fibroblasts (HGFs) are the most abundant cells in gingival connective tissue, and human periodontal ligament fibroblasts (HPLFs) are located between the teeth and alveolar bone. HGFs and HPLFs are both crucial for the remodeling and homeostasis of periodontal tissue, and their roles in the pathogenesis of periodontal diseases have been examined for 25 years. Various responses by HGFs or HPLFs contribute to the progression of periodontal diseases. This review summarizes the biological effects of HGFs and HPLFs on the pathogenesis of periodontal diseases.

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“…A recent study on rats demonstrated the therapeutic effectiveness of TCS and an anti-inflammatory flurbiprofen-loaded nanogels system in ligature-induced experimental periodontitis in rats [ 97 ]. TCS activity in periodontitis is related to the activation of human periodontal ligament fibroblasts that are induced by lipopolysaccharide from Porphyromonas gingivalis [ 98 ]. Recently, the link between TCS and chitosan, a natural polymer that may act as a drug delivery agent and exerts antibacterial and anti-inflammatory activities [ 99 ], has been investigated in the prevention and/or treatment of inflammation in periodontal diseases.…”

Section: Studies On Toothpastes Containing Tcsmentioning

confidence: 99%

Triclosan: A Small Molecule with Controversial Roles

et al. 2022

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Triclosan (TCS), a broad-spectrum antimicrobial agent, has been widely used in personal care products, medical products, plastic cutting boards, and food storage containers. Colgate Total® toothpaste, containing 10 mM TCS, is effective in controlling biofilm formation and maintaining gingival health. Given its broad usage, TCS is present ubiquitously in the environment. Given its strong lipophilicity and accumulation ability in organisms, it is potentially harmful to biohealth. Several reports suggest the toxicity of this compound, which is inserted in the class of endocrine disrupting chemicals (EDCs). In September 2016, TCS was banned by the U.S. Food and Drug Administration (FDA) and the European Union in soap products. Despite these problems, its application in personal care products within certain limits is still allowed. Today, it is still unclear whether TCS is truly toxic to mammals and the adverse effects of continuous, long-term, and low concentration exposure remain unknown. Indeed, some recent reports suggest the use of TCS as a repositioned drug for cancer treatment and cutaneous leishmaniasis. In this scenario it is necessary to investigate the advantages and disadvantages of TCS, to understand whether its use is advisable or not. This review intends to highlight the pros and cons that are associated with the use of TCS in humans.

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Triclosan inhibits the activation of human periodontal ligament fibroblasts induced by lipopolysaccharide from <i>Porphyromonas gingivalis</i>

Cited by 8 publications

References 24 publications

Histone lactylation promotes cell proliferation, migration and invasion through targeting HMGB1 in endometriosis

Histone lactylation promotes cell proliferation, migration and invasion through targeting HMGB1 in endometriosis

Biological Roles of Fibroblasts in Periodontal Diseases

Triclosan: A Small Molecule with Controversial Roles

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