TRIENNIAL GROWTH SYMPOSIUM: Neural regulation of feed intake: Modification by hormones, fasting, and disease1,2

Sartin, James L.; Whitlock, Brian K; Daniel, Joseph A

doi:10.2527/jas.2010-3399

Cited by 30 publications

(37 citation statements)

References 148 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The MC4R is a key molecule underlying appetite control and energy homeostasis [11]. In the present study, we found out that BD did not affect the level of α-MSH.…”

Section: Discussionsupporting

confidence: 41%

Effect of One Unit Blood Donation on Appetite-Related Biomarkers

Erdamar¹,

Çakmak²

2016

CIM

View full text Add to dashboard Cite

Purpose: It is commonly reported that blood donation (BD) leads to an increase in appetite. To investigate this claim, a questionnaire was offered to 306 people who had a history of BD at least once in their life. Following a positive outcome from the questionnaire, we further investigated the impact of BD on appetite. Materials and Methods:The questionnaire study consists of a 5-question survey with VAS was performed on 399 volunteers. Later, 108 volunteers were enrolled in a laboratory study. Blood samples were withdrawn before and after BD.Leptin, ghrelin, neuropeptide-Y (NPY), and alpha-melanocyte stimulating hormone (α-MSH) levels were measured by ELISA kits. VAS assessment was also performed on all participants before and after BD.Results: There was a significant decrease in the level of leptin but the levels of ghrelin, NPY and α-MSH were unchanged. A significant change in VAS value in terms of appetite was also observed. Conclusion:The elevation of appetite after BD is predominantly psychological. Hormonal changes may contribute to the control of hypothalamic hunger and satiety centers.SUPPLEMENT

show abstract

“…The MC4R is a key molecule underlying appetite control and energy homeostasis [11]. In the present study, we found out that BD did not affect the level of α-MSH.…”

Section: Discussionsupporting

confidence: 41%

Effect of One Unit Blood Donation on Appetite-Related Biomarkers

Erdamar¹,

Çakmak²

2016

CIM

View full text Add to dashboard Cite

show abstract

“…It is tempting to speculate that the innate immune system could somehow react to metabolic changes by modulating the balance between orexygenic and anorexigenic signals in the hypothalamus (Perry and Wang, 2012;Sartin et al, 2011), and/or regulating the levels of lipomobilization and plasma NEFA, which are also sensed by TLR4 for further possible feedback regulations (Suganami et al, 2007).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Moreover, some of the signs attributed to SARA are dysfunctions common also to other digestive and metabolic disorders. These may affect the complex perception of satiety (Sartin et al, 2011), cause the release and absorption of immune-stimulating molecules such as lipopolysaccharides or histamine (Eckel and Ametaj, 2016;Minuti et al, 2014;Minuti et al, 2015;Nocek, 1997) and determine the modification of the microbiota (Minuti et al, 2015;Weimer, 2015;Yáñez-Ruiz et al, 2015). Because of this complexity, we have investigated the possible role of other factors involved in the forestomach functions.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Innate immune responses to metabolic stress can be detected in rumen fluids

Trevisi

Riva

Filipe

et al. 2018

Research in Veterinary Science

View full text Add to dashboard Cite

Many production diseases of dairy cows are related to digestive troubles. The rumen subacute acidosis is the most relevant one, albeit not easily recognized. Recent studies suggest that forestomachs can perform regulatory actions at both regional and systemic levels, since forestomach walls express immune receptors and cytokines, and the rumen liquor is infiltrated by leukocytes. Therefore, the rumen fluid could be conveniently collected for investigating metabolic production diseases. Thus, we investigated the origin of the leukocytes of the rumen fluid and demonstrated that they partly derive from saliva. Next, we carried out a field survey of innate immunity in rumen fluids of 128 cows from 12 dairy farms, along with clinical inspections, assessment of milk yield, rumen pH, volatile fatty acids (VFA) and major inflammo-metabolic parameters. Significant statistical correlations were found between immune markers in rumen fluids and biochemical parameters. A significant negative correlation was found in rumen between CD45 gene expression (leukocyte infiltration) and pH level. B cells were the most frequent mononuclear leukocyte population in the rumen liquor and their infiltration was negatively affected by low ruminal pH and high concentrations of VFA. Moreover, total Ig and IgM in rumen fluids were negatively correlated with ruminal pH and positively correlated with uremia.Our data suggest that forestomach immune responses could be directed to "dangers" arising within the forestomach environment. The immune markers could integrate consolidated diagnostic parameters (e.g. rumen pH) and contribute to robust, early diagnosis of tricky digestive troubles of cattle.

show abstract

“…For example, postprandial plasma metabolite and hormone concentrations occurring in response to the latest feed intake are thought to provide feedback signals that are detected, integrated, and translated into anorexic responses by neurons of the hypothalamus to terminate feed intake and delay hunger (Sartin et al, 2011). In this regard, the relations between feed intake and periprandial plasma insulin and ghrelin, and also nutrient signals such as glucose, NEFA, or BHBA, have been intensively studied in cows (Bines et al, 1983;Wylie et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Short-term feed intake is regulated by macronutrient oxidation in lactating Holstein cows

Derno

Nürnberg

Schön

et al. 2013

Journal of Dairy Science

View full text Add to dashboard Cite

In addition to plasma metabolites and hormones participating as humoral signals in the control of feed intake, oxidative metabolic processes in peripheral organs also generate signals to terminate feeding. Although the degree of oxidation over longer periods is relatively constant, recent work suggests that the periprandial pattern of fuel oxidation is involved in regulating feeding behavior in the bovine. However, the association between periprandial oxidative metabolism and feed intake of dairy cows has not yet been studied. Therefore, the aim of this study was to elucidate possible associations existing between single feed intake events and whole-body net fat and net carbohydrate oxidation as well as their relation to plasma metabolite concentrations. To this end, 4 late-lactating cows equipped with jugular catheters were kept in respiratory chambers with continuous and simultaneous recording of gas exchange and feed intake. Animals were fed ad libitum (AL) for 24 h and then feed restricted (RE) to 50% of the previous AL intake for a further 24 h. Blood samples were collected hourly to analyze β-hydroxybutyrate (BHBA), glucose, nonesterified fatty acids (NEFA), insulin, and acylated ghrelin concentrations. Crosscorrelation analysis revealed an offset ranging between 30 and 42 min between the maximum of a feed intake event and the lowest level of postprandial net fat oxidation (FOX net ) and the maximum level of postprandial net carbohydrate oxidation (COX net ), respectively. During the AL period, FOX net did not increase above −0.2 g/min, whereas COX net did not decrease below 6 g/min before the start of the next feed intake event. A strong inverse cross-correlation was obtained between COX net and plasma glucose concentration. Direct cross-correlations were observed between COXnet and insulin, between heat production and BHBA, between insulin and glucose, and between BHBA and ghrelin. We found no cross-correlation between FOX net and NEFA. During RE, FOX net increased with an exponential slope, exceeded the threshold of −0.2 g/min as indicated by increasing plasma NEFA concentrations, and approached a maximum rate of 0.1 g/min, whereas COX net decayed in an exponential manner, approaching a minimal COX net rate of about 2.5 g/min in all cows. Our novel findings suggest that, in late-lactating cows, postprandial increases in metabolic oxidative processes seem to signal suppression of feed intake, whereas preprandially an accelerated FOX net rate and a decelerated COX net rate initiate feed intake.

show abstract

TRIENNIAL GROWTH SYMPOSIUM: Neural regulation of feed intake: Modification by hormones, fasting, and disease1,2

Cited by 30 publications

References 148 publications

Effect of One Unit Blood Donation on Appetite-Related Biomarkers

Effect of One Unit Blood Donation on Appetite-Related Biomarkers

Innate immune responses to metabolic stress can be detected in rumen fluids

Short-term feed intake is regulated by macronutrient oxidation in lactating Holstein cows

Contact Info

Product

Resources

About