Trifasciatosides A–J, Steroidal Saponins from <i>Sansevieria trifasciata</i>

Ethnobotany, Pharmacology and Phytochemical Investigations of the Seeds of &lt;i&gt;Pentaclethra macrophylla&lt;/i&gt; Benth (Mimosaceae)

“…The above data suggested that, the aglycone parts of the two aromatic compounds are derivatives of 2-hydroxymethyl-5-(2-hydroxypropan-2-yl)-phenol [27] (C 1b -1'). From the 1 H and 13 C NMR data (Table 1), it was evident that 1 was a mixture of two glycosylated aromatic monoterpenoids. The difference between the two aglycone parts was the presence of only one oxymethylene group at δ C 61.3 (C 1a -7) in compound 1a and a carboxyl group at δ C 174.5 (C 1b -7) in compound Table 1.…”

Structures and Bioactivities of Steroidal Saponins Isolated from the Genera Dracaena and Sansevieria

“…There is not a general specific procedure for the isolation of steroidal saponins from Dracaena and Sansevieria ; instead, methods are analogous to those used for other natural saponins [ 24 ], for example from Agave species [ 25 ]. Based on our personal experience and key references in the literature [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ], some general guidelines can, however, be suggested. Soon after collection, vegetal material is quickly air-dried in the shade to avoid enzymatic or microbial degradation and is then minced and cold- or heat-extracted by maceration or in a Soxhlet with MeOH or EtOH, or with 40–70% aqueous alcohol.…”

“…Subsequently, the structure of a homogeneous saponin is established by a combination of chemical and spectroscopic methods [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. Chemical reactions are sample demanding and usually require tens of milligrams of a saponin, while spectra can be determined on a few milligrams of a substance.…”

“…Numerous informative examples of the application of these techniques can be found in publications reporting saponins listed in the following tables [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ].…”

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“…Although there are no scientific reports on the phytochemical and biological studies of this plant, its leaves are used in the West Region of Cameroon for the treatment of microbial infections, epilepsy and convulsions. In our continuous search of potentially bioactive steroidal glycosides from Cameroonian medicinal plants [2][3][4][5], we have investigated the MeOH extract from the leaves of D. viridiflora, leading to the isolation and structure elucidation of ten secondary metabolites including trillin 1, prosapogenin A of dioscin 2, prosapogenin B of dioscin 3, dioscin 4, gracillin 5, methylprotodioscin 6, cylicodiscoside 7, stigmasterol 8, stigmasterol 3-O-β-D-glucopyranoside 9, and allantoin 10. Since steroids have been a rich source of agents with potential pharmaceutical applications that have inspired the synthesis of new analogues with promising pharmacological activities [6], some isolated compounds were acetylated and three previously undescribed 22,26-epoxycholesta-5,22-diene derivatives 15-17 were prepared by rearrangement/acetylation in the presence of ZnCl 2 /Ac 2 O (Figure 1).…”