Trifluoromethylfurans II

“…No. 773-76-2, chemically named 5,7-dichloro-8-hydroxyquinoline, chemical structure shown in Figure ) is classified by one of some representative 8-hydroxyquinoline derivatives which has efficient antifungal, antibacterial, antiamoebic, bacteriostatic, fungistatic, and antiprotozoal activities, especially used to treat intestinal amebiasis. − It can extensively form a small number of metal chelates used as an analytical reagent and a chelating extracting agent, − which are successfully employed in solid–liquid extraction for rare earth elements such as Ce 3+ and Tb 3+ . Meanwhile, research continues on the compatibility application of chloroxine in a shampoo that is rather efficient for curing dandruff and seborrheic dermatitis as an synthetic antibacterial substance .…”

Section: Introductionmentioning

confidence: 99%

Cosolvency and Mathematical Modeling Analysis of Chloroxine in Some Binary Solvent System

Shi¹,

Xie²,

Xu³

et al. 2018

J. Chem. Eng. Data

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Equilibrium solubilities of chloroxine in binary solvent mixtures of ethyl acetate plus methanol, ethanol, n-propanol, and isopropanol were measured by the static equilibrium method in the temperature range of 283.15−333.15 K at pressure of 1 atm. The solubility data is positively increased with increasing temperature at different solvent composition ranging from 0 to 1 and decreased with the increasing mass fraction of alcohol in each binary system, and the maximum solubility of 7.819 × 10 −3 at 333.15 K was found in neat ethyl acetate. Under the same composition of ethyl acetate and temperature conditions, the solubility of chloroxine was greater in (methanol + ethyl acetate) than in the other three solution mixtures. Several mathematical models, that is, the Jouyban−Acree model, Van't Hoff−Jouyban−Acree model and Apelblat−Jouyban−Acree model were adopted to correlate the measured solubility values. As a result, the calculated data are in alignment to measured values at evaluated temperatures and RAD (× 10 −2 ) and RMSD (× 10 −4 ) data were no more than 3.49 and 0.94, respectively. X-ray powder diffraction serves to analyze the equilibrium solid phase crystal of chloroxine and results turns out that no polymorphic transformation, solvate formation or crystal transition in the whole solvent crystallization process.

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Feist‐Bénary Reaction

2010

Comprehensive Organic Name Reactions and Reagents

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The synthesis of furan derivatives by treatment of an α‐halo ketone and β‐dicarbonyl compound with a base is known as the Feist‐Bénary condensation. The bases used are normally ammonia and pyridine, however, it was found advantageous to use aqueous pyridine to effect this reaction instead of ammonia, because the production of pyrrole derivative is obviated and the yield of the furan derivative is increased. The intermediate dihydrofuran has been isolated with good diastereoselectivity under mild conditions. This reaction has been extended to prepare furan from α,β‐dichloroethyl ether and β‐ketoester in aqueous pyridine solution to reduce the formation of pyrrole.

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Trifluoromethylfurans II

Cited by 9 publications

References 10 publications

Synthesis of fluorofurans and perfluoroalkylfurans

Synthesis of fluorofurans and perfluoroalkylfurans

Cosolvency and Mathematical Modeling Analysis of Chloroxine in Some Binary Solvent System

Feist‐Bénary Reaction

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