Triglyceride Concentration is Independently Associated with Variation in the LPL Gene in African American and European American Women

Abstract

Abstract:Objective: The regulation of triglyceride (TG) metabolism may be affected by many factors including: race/ethnicity, body composition, body fat distribution, insulin action, and the activity of the lipoprotein lipase (LPL) enzyme. This study was designed to identify the independent effects of body composition, body fat distribution, insulin action, and LPL genetic variation on TG and HDL-C concentration. Subjects: The study consisted of premenopausal European American (EA) (n=114) and African American (AA) (n=140) women. Measurements: Body composition was measured by dual-energy X-ray absorptiometry (DXA), intra-abdominal adipose tissue (IAAT) by computed tomography (CT), insulin sensitivity (SI) and the acute insulin response to glucose (AIRg) by intravenous glucose tolerance test, median household income by zip-code. An estimate of individual genetic admixture was obtained from the genotyping of 85 ancestry informative markers and used to control for population stratification. Multiple linear regression analyses were used to identify contributions of body composition, IAAT, SI, AIRg, African genetic admixture, and LPL polymorphisms to TG and HDL-C. Results: AA had lower TG and higher HDL-C than EA. African genetic admixture, IAAT, AIRg, SI, and RS285 were significantly and independently related to TG concentration. SI was the only independent contributor to HDL-C. RS1800590 was not associated with variation in TG or HDL. Conclusion: Triglyceride concentration appears to be multifactorial in origin and emanates in part from variance in LPL RS285. Future investigations are necessary to understand the mechanisms through which gene polymorphisms, body fat distribution, and insulin action influence the lipid profile.

Sinapic Acid Attenuates Cardiovascular Disorders in Rats by Modulating Reactive Oxygen Species and Angiotensin Receptor Expression

“…Triglycerides are transported from the liver to other tissues primarily by VLDL-C. By contrast, the liver does not produce LDL-C, which instead appears to emerge as a VLDL-C derivative after lipoprotein lipase partially eliminates triglycerides [51]. As proposed by Casazza et al [52], a reduction in the lipoprotein lipase activity, leading to reduced triglyceride assimilation from the circulatory system, might explain the noted rise in the levels of triglycerides. The present study found that, in the L-NAME group, the levels of Figure 4: Gene expression of angiotensin II receptors (AT1A, AT1B, and AT2) of treatment groups compared to nontreated control group (relative to GAPDH (RQ)), using the 2 -ΔΔCT method.…”

D-Carvone, a Monoterpene Reverses Alterations in Heart Rate, Nitric Oxide, Aortic Lipids and Enzymatic Antioxidant Status in Nitric Oxide Deficient Hypertensive Rats

“…Large epidemiologic studies have demonstrated that subjects with hypertension have a marked increase in the prevalence of hypercholesterolemia (Yang et al, 2011). The observed increase in TGs might be due to a decrease in the activity of lipoprotein lipase, resulting in decreased uptake of TGs from the circulation (Casazza et al, 2009). Hypertension frequently coincides with elevated levels of triglycerides (TGs).…”