Triglyceride glucose-body mass index and hypertension risk in iranian adults: a population-based study

Abstract

Background Insulin resistance (IR) and obesity are risk factors for hypertension; triglyceride-glucose (TyG) is known as a surrogate for IR. The present study investigated the association between the triglyceride-glucose body mass index (TyG-BMI) index and the risk of hypertension in Iranian adults. Methods This study was conducted on a sample of 8,610 participants from the baseline phase of the Ravansar non- communicable diseases (RaNCD) in Iran. A logistic regression model was used to evaluate the relationship between TyG-BMI and hypertension. Receiver operating characteristic (ROC) curve analysis was conducted to estimate the predictive power of TyG-BMI for hypertension. Results A total of 4176 men and 4434 women with an average age of 46.74 years were examined. The anthropometric indices were significantly higher in hypertensive than normotensive subjects (P < 0.001). The level of physical activity was significantly higher in the bottom quartiles (P < 0.001). The odds of hypertension in the highest quartile and 3.10 (95% CI: 2.28, 4.16) times significantly higher than the bottom quartile of the TyG-BMI index. The discriminating ability of TyG-BMI to predict blood pressure was 61% (AUC: 0.61; 95% CI: 0.57, 0.63), and higher than BMI and TyG. Conclusion The TyG-BMI index is associated with an increase in the odds of hypertension. Therefore, the TyG-BMI index can be a new clinical index for early diagnosis of hypertension. Lifestyle modifications such as weight control through physical activity and a healthy diet can help improve IR and prevent hypertension.

An analysis of factors influencing cognitive dysfunction among older adults in Northwest China based on logistic regression and decision tree modelling

“…Accordingly, both logistic regression and decision tree models showed that literacy was a key risk factor for cognitive dysfunction in older adults. The association between a high BMI and an increased risk of cognitive dysfunction in the present study may be because a high BMI tends to be associated with an increased risk of cardiovascular diseases such as hypertension, hyperlipidaemia, and diabetes mellitus [ 19 – 21 ], and these cardiovascular diseases may have an impact on the mitochondrial network system [ 22 ], which affects cerebrovascular oxygen sensing in the brain and can lead to cognitive decline. In addition, in a state of obesity, adipose tissue secretes a number of inflammatory factors, such as interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α) [ 23 ], which may cause an inflammatory response in the circulatory system and adversely affect brain function, thereby increasing the risk of cognitive decline.…”

Body Mass Index is Associated with blood pressure and vital capacity in medical students

“…Simultaneously, excess fat triggers the secretion of proinflammatory cytokines, contributing to atherogenesis. Eventually, these factors disrupt blood pressure regulation, potentially leading to elevated blood pressure or hypertension [ 28 , 29 ]. Hence, it is imperative for young individuals to prioritize maintaining a lower BMI to prevent and manage hypertension effectively [ 30 ].…”

Clinical features of early-onset type 2 diabetes and its association with triglyceride glucose-body mass index: a cross-sectional study

“…Recently, a study focused on the triglyceride glucose-body mass index (TyG-BMI), a derivative of body mass index (BMI) and TyG, which can simultaneously capture BMI, blood glucose and lipid profiles, and more closely reflect IR than TyG ( 21 ). Additionally, TyG-BMI has good predictive performance in hypertension, metabolic syndrome, nonalcoholic fatty liver disease, prediabetes, and diabetes ( 22 – 28 ). Since early-onset T2D is closely associated with IR and obesity, we hypothesized that TyG-BMI may be a useful predictor of early-onset T2D.…”