Triglycerides + high‐density‐lipoprotein‐cholesterol dyslipidaemia, a coronary risk factor in elderly women: the CArdiovascular STudy in the ELderly

Abstract

TG and HDL-C were independent predictors of CHD mortality in elderly women. The combination high TG + low HDL-C quadrupled the risk of CHD mortality in this gender only.

Prospective studies on the relationship between high-density lipoprotein cholesterol and cardiovascular risk: a systematic review

“…In accordance with these results, the APCSC study [5,8] found that the association between HDL-C and CVD risk was consistent across both TC and TG levels, whereas the results of the PSC [6] showed that the association was consistent across non-HDL-C levels. In addition, although insufficient to determine the consistency of the association, 36 out of the total 58 prospective studies identified some evidence of a significant inverse association between HDL-C and CVD risk even when controlling for other lipid risk Table 6 Summary of overall study analyses in men, women, and combined analyses of men and women showing a statistically significant inverse association between HDL-C and all CVD outcomes [55-57,59-61, 65,66,69,70,73,74,76,77,79,80,86,88,91,93, 96,98-103,105,110,112,116] [ 55,57,[67][68][69][70]79,81,88,102,115] [58, [62][63][64]75,82,89,90,92,97,104,107] CHD/CVD mortality Total 21 (2) factors. However, in interpreting these results, it is important to note that the associations between various lipids, with the exception of HDL-C, and CVD risk may be altered when lipid measurements are performed in nonfasting versus fasting patients [159], which may partly explain the variations in the strength of the associations noted in this review.…”

Role of Gender in the Prevalence of Metabolic Syndrome and Its Related Risk Factors in Shiraz Healthy Heart Center Population

“…Additionally, transfer of TG from TG-rich lipoproteins to HDL-c is done using this enzyme in exchange for cholesteryl esters, and that's why a negative correlation between these two variables can be found according to CETP activity (26). HDL-c and TG are considered important risk factors for CVD (27,28) and these correlations can be important. Moreover, BMI and waist circumference are considered the markers of adiposity.…”

Reversal of Metabolic Syndrome Characteristics

“…Results demonstrated that high triglycerides and low HDL-C levels were independent predictors of increased CHD mortality in women; in fact, the combination of those two markers nearly quadrupled their risk. 17 Other research has focused on the therapeutic implications of MetS diagnoses, and many studies have investigated the utility of lifestyle changes (especially improved exercise and diet) in treating the underlying causes of metabolic syndrome. 18 For example, studies have already shown that the risk of developing MetS is lower for moderately-to-highly fit individuals, and that persons with the condition at baseline can reverse their MetS status within 6 months of starting an exercise program.…”