Trigonelline attenuates hepatic complications and molecular alterations in high-fat high-fructose diet-induced insulin resistance in rats

Afifi, Nehal A.; Ramadan, A.; Erian, Emad Y.; Saleh, Dalia O.; A.Sedik, Ahmed; Badawi, Manal

doi:10.1139/cjpp-2016-0269

Cited by 20 publications

(13 citation statements)

References 54 publications

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“…In accordance with previous studies (Afifi et al, 2016, Lozano et al, 2016, the present study confirms the relationship between HFHF diet-induced IR model in rats and its impact on hepatic tissue such as hepatic steatosis complicated by fibrosis, inflammation, and oxidative stress.…”

Section: Discussionsupporting

confidence: 80%

Resveratrol attenuates hepatic complications associated with insulin resistance: Implications on hepatic HAIR, LAIR, cell energy and DNA fragmentation

2017

J App Pharm Sci

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Metabolic syndrome (MetS) is a chronic condition, often related to obesity, improper diet, insulin resistance (IR); and can lead to significant health complications. Resveratrol (RSV) is a naturally occurring polyphenol recently postulated to be a powerful antioxidant, hepatoprotective and a potential anti-hyperglycemic. Our research aimed to investigate some possible mechanisms of action that may contribute to the efficacy of RSV to reverse the IR and hepatic complications associated with MetS experimentally induced in rats using high fathigh fructose (HFHF) diet model. Results revealed that RSV treatment (40 mg/kg p.o) for ten days protected against IR and hepatic insult as demonstrated by reduction in HOMA-IR, hepatic HAIR and LAIR expression, total cholesterol (TC), triglycerides (TG), TNF-α levels, oxidative and nitrosative stresses, serum AST and ALT. Furthermore; increasing serum albumin and total protein levels and improving hepatic tissue; cell energy status by increasing adenylate energy charge (AEC) and reducing AMP/ATP ratio and preserving hepatic tissue cellular integrity represented by lowering 8-hydroxy-2-deoxyguanosine (8-OHDG); the results were comparable to those of metformin. As a conclusion; using RSV could be valuable in treatment of hepatic complications associated with MetS and its efficacy probably involves enhancement of cell energy as well as conservation of cellular integrity.

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Section: Discussionsupporting

confidence: 80%

Resveratrol attenuates hepatic complications associated with insulin resistance: Implications on hepatic HAIR, LAIR, cell energy and DNA fragmentation

2017

J App Pharm Sci

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“…The signs and symptoms of metabolic syndrome may be induced in rats by feeding them diet rich in carbohydrates and fat 10 . The multifactorial disease NAFLD has many complex pathophysiologies, among which insulin resistance (IR), obesity and dyslipidemia are well known clinical markers 8,11 . Hepatic fat accumulation results from the synergistic effects of oxidative stress, hepatic lipid dysregulation and pro-inflammatory cytokines.…”

Section: Introductionmentioning

confidence: 99%

High-fat diet-induced metabolic syndrome and oxidative stress in obese rats are ameliorated by yogurt supplementation

Lasker

Rahman

Parvez

et al. 2019

Sci Rep

176

108

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The main objective of this experiment was to determine the effects of yogurt supplementation on fat deposition, oxidative stress, inflammation and fibrosis in the liver of rats with high-fat (HF) diet-induced obesity. Male Wistar rats were used in this study and were separated into the following four different groups: the control, control + yogurt, high fat and high fat+ yogurt groups. The high fat groups received a HF diet for eight weeks. A 5% yogurt (w/w) supplement was also provided to rats fed the HF diet. Yogurt supplementation prevented glucose intolerance and normalized liver-specific enzyme activities in the HF diet-fed rats. Yogurt supplementation also significantly reduced the levels of oxidative stress markers in the plasma and liver of HF diet-fed rats. Moreover, inflammatory cell infiltration, collagen deposition and fibrosis in the liver of HF diet-fed rats were also prevented by yogurt supplementation. Furthermore, yogurt supplementation normalized the intestinal lining and brush border in HF diet-fed rats. This study suggests that yogurt supplementation potentially represents an alternative therapy for the prevention of metabolic syndrome in HF diet-fed rats.

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“…[ 59 ] The present data showed increased MDA associated with decreased SOD and CAT activities in insulin‐resistant diabetic rats; these results are in line with those of previous studies that reported that lipid peroxidation significantly increased during hyperglycemia. [ 60,61 ] Under hyperglycemic conditions, SOD may undergo glycation at specific lysine residues. [ 62 ] In addition, CAT is susceptible to free radical attack, [ 63 ] thus inactivating them.…”

Section: Discussionmentioning

confidence: 99%

Lansoprazole enhances the antidiabetic effect of dapagliflozin in fortified diet‐fed streptozotocin‐treated diabetic rats

Gamil

Fattah

Ahmed

et al. 2020

J Biochem & Molecular Tox

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Dapagliflozin (DAPA) is used for treating type 2 diabetes, whereas lansoprazole (LPZ) is used as a traditional antiulcer drug. The present study investigated the possible antidiabetic effects of LPZ on fortified diet‐fed streptozotocin (FDF/STZ)‐induced insulin‐resistant diabetic rats. On the basis of the current results, it can be concluded that LPZ could be used as an add‐on drug along with the conventional treatment for T2D as it showed beneficial effects in the current experimental model of insulin resistance.

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Trigonelline attenuates hepatic complications and molecular alterations in high-fat high-fructose diet-induced insulin resistance in rats

Cited by 20 publications

References 54 publications

Resveratrol attenuates hepatic complications associated with insulin resistance: Implications on hepatic HAIR, LAIR, cell energy and DNA fragmentation

Resveratrol attenuates hepatic complications associated with insulin resistance: Implications on hepatic HAIR, LAIR, cell energy and DNA fragmentation

High-fat diet-induced metabolic syndrome and oxidative stress in obese rats are ameliorated by yogurt supplementation

Lansoprazole enhances the antidiabetic effect of dapagliflozin in fortified diet‐fed streptozotocin‐treated diabetic rats

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