Triiodothyronin, Thyroxine and Thyrotropin in Vitiligo

Abstract

BackgroundVitiligo is a common pigmentary disorder of the skin, affecting individuals globally. Not only is this ailment psychologically incapacitating, it also has a high incidence of autoimmunity, signifying that its manifestations may be the portrayal of dysfunction of immune system. ObjectiveThe aim of this study is to find out the situations of abnormal thyroid function test (TFT) in vitiligo patients. MethodsA prospective cross sectional study was conducted at the Dhulikhel Hospital, KUTH, Dhulikhel during November 2008 to January 2011 with the objective to assess the thyroid function tests in vitiligo patients. ResultsTotal 66 vitiligo patients with male 30 (45%) and female 36 (55%). Total 26 (39.39%) vitiligo patients have been found to have abnormal thyroid function test. Among them 10 had abnormal T3, seven had abnormal T4 and 12 had abnormal TSH level. Thyroid function test were normal in other vitiligo patients. Total seven vitiligo had high level of T3 than normal value, four male and three female. Two had higher level of T4 above 2.0 ng/dl and all were male, while five had abnormally low level of T4 with three male and two female. There were seven vitiligo patient with increased T3 level and three with decreased T3 level, among them six were males and four were females, the age group was ranged from seven to 68 years old. The T4 level were found abnormal in seven vitiligo patients among which five were males and two were females with the age group ranging from 7 to 51 years. ConclusionsThere has been significant association of thyroid disorder in the patient with vitiligo. Therefore, patient with vitiligo need to undergo thyroid function test to rule out the thyroid disorder and prevent from long-term complications.DOI: http://dx.doi.org/10.3126/kumj.v9i2.6279Kathmandu Univ Med J 2011;9(2):7-10

Concurrent Vitiligo and Psoriasis

“…39.4% of patients were found to have abnormal thyroid function test especially hypothyroidism. 5 Based on a retrospective study on 712 patients with vitiligo [446 female (63%) and 266 male (37%)}, 21 (3%) of them had associated psoriasis [11 male and 10 female]. 7 Vitiligo was generalized in 16 cases and psoriasis was psoriasis vulgaris in 18 patients.…”

“…5 A clinical diagnosis of coexisting vitiligo with unstable plaque psoriasis was made. Individual skin biopsies were taken from three sites: vitiligo, psoriasis and from psoriasis superimposed on vitiligo.…”

Expression of melanocortin 1 receptor before and after narrowband UVB phototherapy treatment in patients with stable vitiligo: A prospective study

“…In particular, in the subjects who presented a high response to treatment (greater than 30% repigmentation), the levels of this hormone were found to be decreased (104.37±14.27 ng/dl) compared to the groups of patients who displayed a low or medium response to treatment, which exhibited substantially higher levels of this hormone. In a retrospective study conducted by Subba et al, alterations in the levels of T3, T4 and TSH in subjects affected by vitiligo were described (32). In a study conducted in a Turkish population, high levels of T3 and T4 were described in subjects with different types of vitiligo; and progression of this disease was seen in comparison with control subjects (33).…”