"Triiodothyronine (T 3 ) toxicosis". Its role in Graves' disease

Ivy, Horace K.

doi:10.1001/archinte.128.4.529

Cited by 19 publications

(4 citation statements)

References 16 publications

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“…Ivy et al [ 10] reported a 19 year old male with T3 toxicosis accompanied by periodic paralysis. In this case, however, free T4 level was ele vated to 4.7 ng/100ml (normal; 0.8-2.8 ng/100ml) and total T4 level was normal.…”

Section: Discussionmentioning

confidence: 99%

Triiodothyronine (T<sub>3</sub>) Toxicosis with Hypokalemic Periodic Paralysis

Sunohara¹,

Satoyoshi²

1984

Eur Neurol

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A case of triiodothyronine (T₃) toxicosis associated with hypokalemic periodic paralysis is reported. Thyrotoxic manifestation was minimal except for mild struma. Serum T₃ levels were moderately elevated, though other thyroid function tests were within the normal range. The patient was treated with methimazole, and paralytic attacks ceased. This is the first report of this combination and the necessity of careful thyroid function tests in sporadic periodic paralysis is emphasized.

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Section: Discussionmentioning

confidence: 99%

Triiodothyronine (T<sub>3</sub>) Toxicosis with Hypokalemic Periodic Paralysis

Sunohara¹,

Satoyoshi²

1984

Eur Neurol

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“…Due to thyroxine binding globulin levels interfering with total thyroid hormone levels, it is the standard of care to obtain free levels of T4 and/or T3. In some cases, only the T3 is elevated with suppressed TSH, condition known as T3 toxicosis [37]. The ratio of total T3 to total T4 can also be useful in assessing the etiology of thyrotoxico sis when scintigraphy is contraindicated.…”

Section: Laboratory Workupmentioning

confidence: 99%

Pediatric Graves’ Disease

Bansal

Umpaichitra²,

Desai³

et al. 2015

Int J Endocr Metab Disord

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Graves' disease is the most common cause of hyperthyroidism in children. It is characterized by suppressed thyroid stimulating hormone and elevated thyroxine levels with varying levels of thyroid stimulating immunoglobulins; and evidence of increased iodine uptake on thyroid scan. It is a multisystem disease with interplay of genetics and environmental factors. Due to the insidious onset of symptoms, diagnosis is often delayed leading to poor growth and development. The disorder could present at any age including neonatal period due to transfer of maternal antibodies in context of maternal Graves' disease. Herein, we review the current literature for Graves' disease affecting children and adolescents.

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“…Although the original chemical methods (Nauman et al, 1967;Hollander, 1968;Sterling, 1970;Ivy et al, 1971;) and some radioimmunoassays (Gharib et al, 1971) have given higher values, it is generally agreed that the normal serum concentration of T3 is about 100-150 ng/100 ml, which is the approximate range achieved in most radioimmunoassays (Brown et al, 1970;Oddie et al, 1971;Chopra et al, 1971b;Lieblich & Utiger, 1972) and by a gas-liquid chromatographic technique (Nihei e l af., 1971). If the normal range of serum thyroxine is taken as 4-11 pg/lOO ml, this means that T3 accounts for about 1-2% of the total circulating thyroid hormone.…”

Section: T 3 I N S E R U Mmentioning

confidence: 99%

Triiodothyronine

Hoffenberg

1973

Clinical Endocrinology

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After 20 years in the wilderness, 3,5,3′‐triiodo‐l‐thyronine (T3) has come back home, for it is exactly 20 years since Gross & Pitt‐Rivers (1952) first drew attention to its presence in human serum. A few years later Pitt‐Rivers et al. (1955) demonstrated its formation from thyroxine (T4) given to patients with athyreotic myxoedema, and in 1957 Maclagen et al. reported thyrotoxicosis with elevated plasma concentration of T3 and normal concentration of T4‐the first identifiable instance of what is now referred to as ‘T3 toxicosis’. Despite these early suggestions of significant physiological and pathological contributions, T3 was regarded as a minor and unimportant iodinated compound until the development of an improved biochemical assay (Sterling et al., 1969) paved the way for wider recognition of its role in health and disease and stimulated the development of a sensitive and dependable radioimmunoassay. In the past few years information about the action, metabolism and clinical significance of T3 has rapidly accrued; this review attempts to put together some of this new and exciting information. Because methods for the assay of T3 in biological fluids have only recently been introduced, the validity of the various techniques will be considered first.

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"Triiodothyronine (T 3 ) toxicosis". Its role in Graves' disease

Cited by 19 publications

References 16 publications

Triiodothyronine (T<sub>3</sub>) Toxicosis with Hypokalemic Periodic Paralysis

Triiodothyronine (T<sub>3</sub>) Toxicosis with Hypokalemic Periodic Paralysis

Pediatric Graves’ Disease

Triiodothyronine

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