Trikatu, an herbal compound as immunomodulatory and anti-inflammatory agent in the treatment of rheumatoid arthritis – An experimental study

Murunikkara, Vachana; Rasool, Mahaboobkhan

doi:10.1016/j.cellimm.2013.12.002

Cited by 25 publications

(18 citation statements)

References 25 publications

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“…However, the boosting of antioxidant defence (enzymatic and non‐enzymatic) system by trikatu supplementation in arthritic rats might be primarily due to the free radical scavenging action of piperine, gingerol and shogaols. These findings are in line with the previous studies conducted in our laboratory . Moreover, the reports on the extracts of Zinger officinale and Piper nigrum on their antioxidant activity supports our claim …”

Section: Discussionsupporting

confidence: 94%

“…The adjuvant contained heat‐killed Mycobacterium tuberculosis (10 mg) in paraffin oil (1 mL). Groups III and IV comprised of arthritic rats, treated with trikatu (1000 mg/kg/body weight, oral) and indomethacin (3 mg/kg/body weight intraperitoneal) respectively, from days 11 to 18 after the administration of complete Freund's adjuvant . Periodically, the development of arthritis was monitored by measuring the paw thickness using a vernier scale during the experimental period.…”

Section: Methodsmentioning

confidence: 99%

“…Trikatu is believed to promote health, immunity and longevity by strengthening all tissues of the body . In addition, our laboratory has also reported the anti‐arthritic property of trikatu and its active principles such as 6‐shogaol, 6‐gingerol and piperine on different experimental arthritic models . On the foreground of this, an attempt has been made to evaluate its anti‐arthritic effect with respect to various biochemical, immunological, histopathological and radiological parameters in aduvant‐induced arthritic rats.…”

Section: Introductionmentioning

confidence: 99%

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Trikatu, a herbal compound mitigates the biochemical and immunological complications in adjuvant-induced arthritic rats

Murunikkara

Rasool

2014

Int J Rheum Dis

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Section: Discussionsupporting

confidence: 94%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Trikatu, a herbal compound mitigates the biochemical and immunological complications in adjuvant-induced arthritic rats

Murunikkara

Rasool

2014

Int J Rheum Dis

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“…The incidence of circulating immune complexes has been ascertained for many disease conditions (Haymen 1990, Pandey 2013, Maheswari et al 2014) and the level of circulating immune complexes has been correlated with the activity of certain diseases. Moreover, the assays have also been used to evaluate the effect of pharmacological therapy on the levels of circulating immune complexes (Murunikkara and Rasool 2014). CICs were the only biomarkers significantly associated with a heaves exacerbation, while the evaluated APPs failed to show any abnormality.…”

Section: Discussionmentioning

confidence: 99%

Circulating immune complexes and markers of systemic inflammation in RAO-affected horses

Niedźwiedź¹,

Jaworski²,

Kubiak³

2014

Polish Journal of Veterinary Sciences

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The aim of this study was to investigate the levels of circulating immune complexes (CICs) and concentration of haptoglobin, fibrinogen and C-reactive protein in the serum of horses with recurrent airway obstruction and healthy controls. The study was conducted on a group of 14 adult Polish Konik horses, kept in uniform environmental and living conditions. Horses were divided into two groups: 7 horses were not affected by any respiratory problem (control group) and 7 horses had a history of recurrent airway obstruction (RAO) (study group). A clinical and laboratory evaluation, endoscopic examination and bronchoalveolar lavage (BAL) were performed in all horses. Levels of circulating immune complexes were significantly (p=0.0057) increased in heaves-affected horses compared to healthy controls (median [25 th -75 th percentiles]) (3.96 [3.96 -4.43] vs. 7.46 [5.13 -11.9]). No significant difference was observed in the levels of the examined acute phase proteins between the groups. Moreover, all results were within the reference range established for horses. The results of this study indicate that heaves in horses is associated with the formation and high level of CICs. Haptoglobin, fibrinogen and C-reactive protein failed as markers of early stage systemic inflammation in the course of RAO.

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“…37 Augmentation of the humoral response to SRBCs was also evident from the significantly increased (P<0.001) number of PFCs in the spleen of mice (Table 4) which can be correlated to the number of B-cells producing SRBC-specific IgM or antigen presenting cells. 30 Comparable data were reported for a polyherbal combination Trikatu 38 and an aqueous extract of Glycyrrhiza glabra in combination with Zinc. 28 The trend shown by levamisole and leflunomide on hemagglutination titre, serum immunoglobulin and number of PFCs was found to be similar to the one observed in DTH response.…”

Section: Gc-ms/ms Analysis Of Hemilmentioning

confidence: 98%

Standardized Extract of Mangifera Indica L. Leaves as an Antimycobacterial and Immunomodulatory Agent

Shailajan¹,

Menon²,

Kulkarni³

et al. 2016

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Background: Mangifera indica L.; the largest fruit-tree found in India, is an important component of indigenous medical systems. Mangifera indica L. leaves (MIL) have been reported to possess various biological activities and thus, can be a useful source of substances for drug development. Although the leaves have been traditionally used as antibacterial and immunomodulatory agent, there is a paucity of scientific data in support of their efficacy. The purpose of this study was an in-depth evaluation of antimycobacterial and immunomodulatory activity of a standardized extract of MIL. Material and Methods: The hexane extract of Mangifera indica L. leaves (HEMIL) was prepared and standardized. Chromatographic characterization of HEMIL was done using validated HPLC and GC-MS/MS technique. HEMIL was evaluated for antimycobacterial and immunomodulatory activity by using various in vitro and in vivo assays. Results and Discussion: HEMIL showed lupeol and stigmasterol content of 21.04 ± 0.03 mg/g and 16.99 ± 0.04 mg/g, respectively; and total terpenoids content of 112.55 ± 2.16 mg LE/g. GC-MS/MS characterization of the extract confirmed the presence of lupeol and stigmasterol and revealed five other phytochemical constituents. The safety of HEMIL was established in vitro and in vivo. HEMIL showed concentration-dependent inhibition of MTB as evident in REMA and radiorespirometry. HEMIL was also found efficacious in immunomodulatory evaluations using RAW 264.7 cells, human PBMCs, cyclophosphamide induced myelosuppressed mice and SRBCs stimulated mice. Conclusion: The promising results not only support the traditional claim of MIL as antibacterial and immunomodulatory agent but also provide data on their use in food supplements for immuno-pharmacological use.

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Trikatu, an herbal compound as immunomodulatory and anti-inflammatory agent in the treatment of rheumatoid arthritis – An experimental study

Cited by 25 publications

References 25 publications

Trikatu, a herbal compound mitigates the biochemical and immunological complications in adjuvant-induced arthritic rats

Trikatu, a herbal compound mitigates the biochemical and immunological complications in adjuvant-induced arthritic rats

Circulating immune complexes and markers of systemic inflammation in RAO-affected horses

Standardized Extract of Mangifera Indica L. Leaves as an Antimycobacterial and Immunomodulatory Agent

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