Trimetallic nanoparticle-decorated MXene nanosheets for catalytic electrochemical detection of carcinoembryonic antigen via Exo III-aided dual recycling amplifications

2D MXene‐Based Biosensing: A Review

“…Songe et al [333] developed a CEA detection platform by using exonuclease III (Exo III) and trimetallic NP-decorated Ti 3 C 2 (Au-Pd-Pt/Ti 3 C 2 ) electrode as sensing interface. The CEA binds to aptamer-containing hairpin probes and triggers cyclic [327] C) smartphone-based aptasensing platform built from MXene/cDNA-MB for the sensing of Microcystin-LR; D) SWV response of MXene/cDNA-MB towards various concentration of MC-LR aptasensor; [332] E) synthetic route for Au-Pd-Pt/Ti 3 C 2 for development of sensing interface and Exo III-assisted double recycling amplification for CEA analysis; F) DPV of the designed interface towards 1 fgmL −1 to 1 ngmL −1 of CEA; G) current response of sensor in 10 pgmL −1 of CEA in the presence of other interfering species; [333] H) scheme showing Ti 3 C 2 -AuNP utilizing dopamine loaded liposome-based electrochemical immunoassay for PSA; I) DPV response of Ti 3 C 2 -AuNP based immunoassay towards 1 pgmL −1 to 50 ngmL −1 of PSA; J) current response revealing the specificity of the Ti 3 C 2 -AuNP based immunosensor. [334] Figures adapted with permission from: (A, B) ref.…”

“…[332], Copyright 2022, Elsevier; (E–G) ref. [333], Copyright 2022, Elsevier; (H–J) ref. [334], Copyright 2022, Wiley VCH.…”

“…Songe et al. [ 333 ] developed a CEA detection platform by using exonuclease III (Exo III) and trimetallic NP‐decorated Ti 3 C 2 (Au‐Pd‐Pt/Ti 3 C 2 ) electrode as sensing interface. The CEA binds to aptamer‐containing hairpin probes and triggers cyclic splitting of secondary hairpins with the help of Exo III to release ssDNAs which were hybridized to the G‐quadruplex‐integrated triplet‐helix complex (THC) probe on the sensing interface.…”

“…Copyright 2022, Elsevier; (C, D) ref [332],. Copyright 2022, Elsevier; (E-G) ref [333],. Copyright 2022, Elsevier; (H-J) ref [334],.…”

Ionic Liquid-Functionalized ZrO2/Reduced Graphene Oxide Nanocomposites for Carcinoembryonic Antigen Electrochemical Detection

“…Several biosensor-based diagnostic platforms such as electrochemical, optical, and fluorescence are widely utilized for cancer biomarker detection. Electrochemical immunosensors have been explored extensively owing to their fascinating characteristics like high sensitivity and selectivity, ultralow detection limit, rapid detection, cost-effectiveness, ease of fabrication, miniaturization ability, and label-free detection. ,− To construct the electrochemical immunosensor, highly conductive and functional nanomaterials have been employed. They possess abundant functional groups and high surface area for biomolecule immobilization along with high conductivity for sensitive detection. − Evidently, transition metal oxides and their nanocomposites with carbon materials have been widely used for the fabrication of electrochemical immunosensors.…”