Trimetazidine reduces the degree of fibrosis in alkali burns of the esophagus

Yukselen, Vahit; Karaoğlu, Ali Önder; Yenisey, Çiğdem; Tunçyürek, Müge; Özütemîz, Ömer

doi:10.1016/j.jpedsurg.2004.11.036

Cited by 19 publications

(13 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The latter suggests that the anti-fibrotic and anti-apoptotic effects of OLM administration in esophageal caustic burn observed in our study could be also attributed to the suppression of oxidative stress by AT1R antagonism. This hypothesis is in agreement with the results of previous studies which demonstrated partially successful treatment of caustic esophageal burns by increasing the antioxidant capacity of the tissue [25][26][27][28][29][30][31][32][33][34][35]. The present study provides new evidence that the renin-angiotensin system can be a promising target for the treatment of esophageal burns caused by corrosive agents.…”

Section: Discussionsupporting

confidence: 93%

A novel approach for preventing esophageal stricture formation: olmesartan prevented apoptosis

Dereli

Krazinski

Ayvaz

et al. 2014

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

Accidentally ingested corrosive substances can cause functional and structural damage to the esophageal tissue resulting in stricture formation. It has been reported that the administration of olmesartan (OLM) can have anti-inflammatory, antifibrotic and antiapoptotic effects on injured tissue. The aim of our study was to check if OLM could prevent formation of scars in the corrosive esophageal burn model. Fifty-one Wistar Albino rats were divided into six groups: Control, Sham, OLM, Sham + OLM, Burn, and Burn + OLM. Olmesartan (5 mg/kg) was given by gavage once per day for 21 consecutive days after injury. The morphology of the esophagus was assessed after Masson trichrome staining, and apoptosis was evaluated using the terminal deoxynucleotidyl transferased UTP nick end labeling (TUNEL) method. The serum nucleosomes (as an indicator of apoptosis), serum p53 protein, and esophageal tissue p53 protein levels of each group were measured by immunoassays. Muscularis mucosa damage, submucosal collagen deposition, and tunica muscularis injury in the Burn + OLM group decreased significantly compared with the Burn group (p < 0.05). Similarly, the number of apoptotic cells in the Burn + OLM group decreased compared with the Burn group (p < 0.05). Serum levels of nucleosomes and p53 and tissue of p53 protein did not differ between the groups. Exogenously administered OLM can effectively prevent the occurrence of esophageal strictures caused by corrosive esophageal burns.

show abstract

Section: Discussionsupporting

confidence: 93%

A novel approach for preventing esophageal stricture formation: olmesartan prevented apoptosis

Dereli

Krazinski

Ayvaz

et al. 2014

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

show abstract

“…The best-known action of TMZ is the inhibition of the b-oxidation pathway of fatty acid metabolism; in addition, TMZ prevents excessive release of free radicals [8,9]. TMZ has been used to prevent a variety of I/R injuries in animal models, including heart, kidney, lung, retina and spinal cord [8,[10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

The protective effects of trimetazidine on testicular ischemia and reperfusion injury in rats

et al. 2007

View full text Add to dashboard Cite

This study was designed to investigate the protective effect of trimetazidine [TMZ; 1-(2, 3, 4-trimethhoxibenzyl)-piperazine dihydrochloride], as an antioxidant agent, on torsion-detorsion-induced biochemical and histopathological changes in experimental testicular ischemia/reperfusion injury in rats. Twenty-seven male Wistar rats weighing 180-220 g were divided into five groups: control (C, n = 4), sham-operated (S, n = 4), ischemia (I, n = 6), ischemia-reperfusion (I/R, n = 6) and ischemia-reperfusion + trimetazidine (I/R + TMZ; n = 7). Control rats were used for basal normal values. In group I, 2 h torsion of the left testis was performed. In I/R and I/R + TMZ groups, following 2 h of torsion, 4 h detorsion of the testis was performed. In ischemia and I/R groups, physiologic saline was administered orally for 7 days, and the rats in I/R + TMZ group were pretreated orally with 5 mg/kg day TMZ for 7 days before inducing ischemia. At the end of each experiment, ipsilateral orchiectomies were performed for the tissue levels of malondialdehyde (MDA), glutathione peroxidase (GPx) enzyme activities and histopathological examinations in all groups. MDA levels were significantly reduced and GPx enzyme activities were significantly increased in testes in I/R+TMZ pretreated group compared to group I and I/R. The mean seminiferous tubular diameter (MSTD) and Johnsen's score were significantly better in I/R+TMZ group than groups I and I/R. Pretreatment with TMZ decreased germ cell apoptosis and caspase-3 expression in the ischemic testis. The present results show that TMZ has a protective activity in the testicular injury caused by I/R, and provide the first evidence of the role of TMZ for the prevention of I/R-induced testicular injury.

show abstract

“…6 Trimetazidine (2,3,4-trimethoxybenzyl-piperazine dihydrochloride; TMZ), which does not have any direct hemodynamic effects, has an anti-ischemic effect at the cellular level. [7][8][9] This drug has an antioxidant effect by protecting the cell against harmful effects of OFRs that arise during ischemia and inflammation. [7][8][9][10][11] By decreasing the inhibition of OFR production and membrane lipid peroxidation, TMZ exerts a protective effect.…”

mentioning

confidence: 99%

“…[7][8][9] This drug has an antioxidant effect by protecting the cell against harmful effects of OFRs that arise during ischemia and inflammation. [7][8][9][10][11] By decreasing the inhibition of OFR production and membrane lipid peroxidation, TMZ exerts a protective effect. [9][10][11][12] On the other hand, TMZ is a chemical agent that also inhibits neutrophil infiltration following ischemia/reperfusion.…”

mentioning

confidence: 99%

Effects of trimetazidine in acute pancreatitis induced by L-arginine

Yeniçerioğlu¹,

Çetinkaya

Gırgın

et al. 2013

Can J Surg

View full text Add to dashboard Cite

Background:In acute pancreatitis, oxygen free radicals (OFRs) and cytokines have been shown to play a role in the failure of pancreatic microcirculation and the develop ment of local tissue damage. We studied the effects of trimetazidine (TMZ), a potent antioxidant and anti-ischemic agent, on acute pancreatitis.Methods: Rats were randomized into 3 groups: a control group (n = 15), a study group (n = 15) in which acute pancreatitis was induced with with L-arginine, and a treatment group (n = 15) in which pancreatitis was induced and treated with TMZ intraperitoneally. The rats were followed for 24 hours. At the 24th hour we determined serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), amylase, lactate dehydrogenase (LDH), interleukin 1-β (IL-1β), interleukin 6 (IL-6) and tumour necrosis factor-α (TNF-α), and the pancreatic tissues were analyzed histopathologically.

show abstract

Trimetazidine reduces the degree of fibrosis in alkali burns of the esophagus

Cited by 19 publications

References 21 publications

A novel approach for preventing esophageal stricture formation: olmesartan prevented apoptosis

A novel approach for preventing esophageal stricture formation: olmesartan prevented apoptosis

The protective effects of trimetazidine on testicular ischemia and reperfusion injury in rats

Effects of trimetazidine in acute pancreatitis induced by L-arginine

Contact Info

Product

Resources

About