Trimethylamine N-oxide reduction is related to probiotic strain specificity: A systematic review

Cantero, Marcos Antonio; Guedes, Macksuelle Regina Angst; Fernandes, Ricardo; Lollo, Pablo Christiano Barboza

doi:10.1016/j.nutres.2022.04.001

Cited by 17 publications

(6 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…That limitation precluded addressing an a priori aim of investigating strain-specific effects of probiotics and compound-specific effects of prebiotics on the GTI burden, which may be sources of unexplained heterogeneity in several of the analyses. Previous meta-analyses and systematic reviews have reported strain-specific efficacy of probiotic interventions against particular illnesses [ 65 , 67 , 69 , 70 ]. These strain-specific effects are likely mediated, in part, by unique mechanisms of action specific to individual probiotic strains [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Orally Ingested Probiotic, Prebiotic, and Synbiotic Interventions as Countermeasures for Gastrointestinal Tract Infections in Nonelderly Adults: A Systematic Review and Meta-Analysis

Fagnant¹,

Isidean²,

Wilson³

et al. 2023

Advances in Nutrition

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Orally Ingested Probiotic, Prebiotic, and Synbiotic Interventions as Countermeasures for Gastrointestinal Tract Infections in Nonelderly Adults: A Systematic Review and Meta-Analysis

Fagnant¹,

Isidean²,

Wilson³

et al. 2023

Advances in Nutrition

View full text Add to dashboard Cite

“…PMID: 35,588,611. 36 Abbreviations : RCT, Randomized Controlled Trial; MetS, Metabolic Syndrome; T2DM, Type 2 Diabetes Mellitus; HgA1c, Hemoglobin A1c; BP, Blood pressure; TMAO, Trimethylamine N-oxide. …”

Section: The Microbiome and Cardiovascular Agingmentioning

confidence: 99%

Addressing the Missing Links in Cardiovascular Aging

Dinetz,

Zeballos-Palacios,

Martinez

2024

CIA

View full text Add to dashboard Cite

The aim of this manuscript is to provide a review of available options to enhance cardiovascular health and prevent cardiovascular disease (CVD) in the aging population using a systems-biology approach. These include the role of the gut microbiome, the early identification and removal of environmental toxins, and finally age related sex hormones and supplement replacement which all influence aging. Implementing such a comprehensive approach has the potential to facilitate earlier risk assessment, disease prevention, and even improve mortality. Further study in these areas will continue to advance our understanding and refine therapeutic interventions for a healthier cardiovascular aging process.

show abstract

“…In any case, even if the results of an experimental study show an obligate role for intestinal microbiota in the generation of TMAO from the dietary lipid phosphatidylcholine [ 51 ], it is still not clear whether specific patterns of microbiota composition would be associated with different levels of TMAO production. This issue is highlighted by the results of a recent meta-analysis showing that supplementation with probiotic Lactobacillus rhamnosus GG was the most efficient in reducing the plasma TMAO level in both humans and animals [ 52 ].…”

Section: State-of-the-art Reviewmentioning

confidence: 99%

The Gut Microbiota and Vascular Aging: A State-of-the-Art and Systematic Review of the Literature

Agnoletti

Piani

Cicero

et al. 2022

JCM

View full text Add to dashboard Cite

The gut microbiota is a critical regulator of human physiology, deleterious changes to its composition and function (dysbiosis) have been linked to the development and progression of cardiovascular diseases. Vascular ageing (VA) is a process of progressive stiffening of the arterial tree associated with arterial wall remodeling, which can precede hypertension and organ damage, and is associated with cardiovascular risk. Arterial stiffness has become the preferred marker of VA. In our systematic review, we found an association between gut microbiota composition and arterial stiffness, with two patterns, in most animal and human studies: a direct correlation between arterial stiffness and abundances of bacteria associated with altered gut permeability and inflammation; an inverse relationship between arterial stiffness, microbiota diversity, and abundances of bacteria associated with most fit microbiota composition. Interventional studies were able to show a stable link between microbiota modification and arterial stiffness only in animals. None of the human interventional trials was able to demonstrate this relationship, and very few adjusted the analyses for determinants of arterial stiffness. We observed a lack of large randomized interventional trials in humans that test the role of gut microbiota modifications on arterial stiffness, and take into account BP and hemodynamic alterations.

show abstract

Trimethylamine N-oxide reduction is related to probiotic strain specificity: A systematic review

Cited by 17 publications

References 44 publications

Orally Ingested Probiotic, Prebiotic, and Synbiotic Interventions as Countermeasures for Gastrointestinal Tract Infections in Nonelderly Adults: A Systematic Review and Meta-Analysis

Orally Ingested Probiotic, Prebiotic, and Synbiotic Interventions as Countermeasures for Gastrointestinal Tract Infections in Nonelderly Adults: A Systematic Review and Meta-Analysis

Addressing the Missing Links in Cardiovascular Aging

The Gut Microbiota and Vascular Aging: A State-of-the-Art and Systematic Review of the Literature

Contact Info

Product

Resources

About