Triorganoblei- und Triorganozinnderivate von Hydroxyaminosäuren und O-Acetylserin / Triorganolead and Triorganotin Derivatives of Hydroxyamino Acids and of O-Acetylserine

Abstract

Bis(triphenyllead) compounds (Ph3Pb)2A [H2A = H2Ser (= L-serine), H2Tyr (= L-tyrosine), H2Phoser (= phosphorylserine)], R3PbAcSer (HAcSer = O-acetylserine; R = Ph, Me) and Ph3SnAcSer have been prepared from R3MOH and the appropriate amino acids. From IR data it is inferred that all compounds are polymeric, and that (Ph3Pb)2A (A = Ser, Tyr) and Me3PbAcSer contain unsymmetrically bridging carboxylate groups and coordinating NH2. For (Ph3Pb)2Phoser a structure with a monodentate carboxylate group and intermolecular coordination of Pb by an NH2- and a P=O-group is proposed. The molecules of Ph3MAcSer (M = Pb, Sn) containing monodentate carboxylate groups are bridged by acetyl-C=O groups.

Characteristic spectral studies and in vitro Antimicrobial and in vivo multi‐infection antifungal activities in mice of new organotin(IV) derivatives of heterocyclic amino acids

“…2 Study of triethyltin binding to rat-liver mitochondria has led to the assignment of two binding sites in the membrane: one of high affinity, the other of low affinity. [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Little definite information exists, however, concerning the reactions of organotin compounds with heterocyclic-ring-containing amino acids. 3 Triorganotin(IV) derivatives have recently received considerable attention due to their high antifungal activities against Ceratocystis ulmi, which causes Dutch elm disease, 4,5 Phytophthora palmivora (Butler) isolated from black pepper and coca leaves, 6 Aspergillus niger and Helminthosporium taulosum 7 and Candida albicans, Cryptococcus neoformans and A. fumigatus.…”