Triple negative breast cancer: 10-year survival update of the applied treatment strategy in Kuwait

Characteristics and Prognosis of Triple-Negative Breast Cancer Patients: a Croatian Single Institution Retrospective Cohort Study

“…The overall absolute 5-year survival rate in our study was strikingly similar to the one observed in the Slovenian 41 and Italian 43 studies, markedly lower than in the Chinese one 48 , where 89% of patients were alive after five years, and markedly better than the Indian cohort analyzed during the similar period, with a reported 3-year OS of 66% 44 . Similar survival results in our cohort to those reported by Slovenian and Italian authors can also partially be interpreted by similar characteristics of patients living in the close geographical area, and by the similar treatments used, i.e.…”

“…With a median age of 58 years, this cohort of patients was comparable to the cohorts in several similar studies in patients with early TNBC conducted in recent years in the relatively close geographical areas (Slovenia, Italy), but also in other parts of the world (Canada) 23,[40][41][42] . Patients younger by ten years were studied in India, Kuwait and Turkey [43][44][45] , which is in line with the well-documented fact that patients with TNBC from these countries are mostly younger compared to other geographical areas. Accordingly, it is not surprising that 64% of patients in our cohort were postmenopausal, compared to a similar population of patients younger by three years in Slovenian study 40 and Italian 42 studies with 60% of postmenopausal patients.…”

“…As expected, the most significant prognostic factors were age, tumor size, and positive lymph nodes 53,55,56 . As in the other studies mentioned, the higher the tumor size and the more lymph nodes affected, indicating a more advanced stage of the disease, the worse is the prognosis [40][41][42][43][44][45]47 . In contrast to our results, where younger patients had higher odds for disease recurrence and death, which is consistent with the known facts about greater aggression of the disease at a younger age and probably different essential biology than the disease in the older population, in the Slovenian study older patients had a higher risk, which is also explained by the fact that a much smaller percentage of older patients are treated with adjuvant chemotherapy 40 .…”

Long-term results of combined treatment of triple-negative breast cancer

“…Серед основних ІГХ типів РМЗ найбільш складним для лікування вважається тричі-негативний РМЗ (ТНРМЗ), при якому експресія основних рецепторів відсутня або дуже слабка [3]. Цей підтип виявляється в 10-20 % випадків РМЗ та характеризується агресивним клінічним перебігом з високою проліферативною активністю та швидкістю росту [4]. Загальні принципи та методи лікування ТНРМЗ схожі з лікуванням інших підтипів раку цієї локалізації.…”

“…Але, за даними багатьох дослідників, у жінок з ТНРМЗ, навіть після радикальних операцій спостерігається досить велика частота локорегіональних та відділених метастазів та більш низька у порівнянні з іншими підтипами виживаність [5,6]. Це спонукає до більш активної онкохірургічної тактики та системного лікування [4,7], але повідомляють й про задовільні безпосередні та відділені результати органозберігаючих операцій [8,9].…”