Triple-negative breast cancer with brain metastasis in a pregnant woman

Abstract

A woman aged 35 years was diagnosed with triple-negative breast cancer in October 2012. During the investigation, it was discovered that she was pregnant, the patient decided to have an abortion. She was submitted to a radical modified mastectomy and adjuvant chemotherapy followed by adjuvant breast radiotherapy of the left breast. 2 months after the adjuvant treatment, she began to have headaches and dizziness. The cranial MRI (head MRI) showed brain metastasis. She was then treated with whole brain radiotherapy, stereotactic radiosurgery and concomitant temozolomide which resulted in complete response. 1.5 year later, she was able to get pregnant and gave birth to a baby without complications. The previous imaging reassessment performed in September 2016 shows no evidence of recurrent breast cancer.

A novel chalcone-based molecule, BDP inhibits MDA-MB-231 triple-negative breast cancer cell growth by suppressing Hsp90 function

“…An increase of mobility has been associated with the metastatic potential of cancer cells and patients with TNBC have a tendency to metastasize to bone, lung, liver, and brain, which contributes to the poor prognosis with short overall survival (36,37). In particular, MMPs are associated with cancer invasion and metastasis.…”

A Review of the Neurosurgical Management of Brain Metastases During Pregnancy

“…Five patients received chemotherapy and radiation both during and after their pregnancies, 15,17,23,36,47 while two patients received treatments after their pregnancies. 34,46 Combined Neurosurgical Intervention and Chemoradiation Therapy Four patients had combined interventions: One patient had chemotherapy during her pregnancy followed by neurosurgical resection and chemoradiation after successful delivery of her child 24 ; the second patient received surgical resection of her metastasis during pregnancy followed by WBRT and chemotherapy after successful delivery of her child 49 ; the third patient received chemoradiation prior to neurosurgical resection followed by further resection at the time of recurrence and WBRT during her pregnancy with the successful delivery of a healthy fetus. 42 Timing of the above interventions with maternal/fetal outcomes is summarized in Table 1.…”